Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Mercury
ions
(Hg2+)
have
been
found
to
disrupt
the
body's
antioxidant
defense
mechanisms,
leading
oxidative
stress
and
physiological
dysfunction.
Early
diagnosis
real-time
monitoring
of
Hg2+
fluctuations
in
organ
damage
are
crucial
but
limited
due
lack
noninvasive
deep
tissue
imaging
probes.
Herein,
a
Hg2+-triggered
targeted
NIR-II
fluorescence/photoacoustic
(PA)
dual-mode
molecular
probe
(NHG-2)
was
developed
for
Hg2+-induced
acute
liver
kidney
injury
mice.
NHG-2
designed
through
rational
adjustment
conjugated
ring
structure
further
screening
processes,
enabling
it
sensitively
recognize
subsequently
open
mitochondrial
targeting,
producing
fluorescence/PA
signals.
This
allowed
injury,
demonstrating
excellent
detection
sensitivity.
Furthermore,
can
be
utilized
evaluate
efficacy
N-acetylcysteine
(NAC)
dual
signal
indication.
Mechanism
studies
suggested
that
NAC
activated
Akt/Nrf2
signaling
pathway,
reversed
changes
related
biomarkers,
restored
membrane
potential.
Thus,
this
study
not
only
presents
first
specific
also
provides
potential
tool
early
treatment
evaluation
pathogenesis
study.
Язык: Английский
MOTS-c mimics remote ischemic preconditioning in protecting against lung ischemia-reperfusion injury by alleviating endothelial barrier dysfunction
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Exploring the therapeutic potential of MOTS-c in age-related macular degeneration: from cellular responses to patient-derived cybrids
Human Cell,
Год журнала:
2025,
Номер
38(2)
Опубликована: Фев. 17, 2025
Язык: Английский
Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Radiation-induced
lung
injury
(RILI)
is
a
prevalent
complication
of
thoracic
tumor
radiotherapy
and
accidental
radiation
exposure.
Pyrroloquinoline
quinone
(PQQ),
novel
vitamin
B,
plays
crucial
role
in
delaying
aging,
antioxidation,
anti-inflammation,
antiapoptosis.
This
study
aims
to
investigate
the
protective
effect
mechanisms
PQQ
against
RILI.
C57BL/6
mice
were
exposed
20
Gy
dose
X-ray
on
entire
thorax
with
or
without
daily
oral
administration
for
2
weeks.
effectively
mitigated
radiation-induced
tissue
damage,
inflammation,
oxidative
stress,
epithelial
cell
apoptosis.
Additionally,
significantly
inhibited
stress
mitochondrial
damage
MLE-12
cells.
Mechanistically,
upregulated
mRNA
protein
levels
MOTS-c
irradiated
Knockdown
by
siRNA
substantially
attenuated
effects
In
conclusion,
alleviates
RILI
preserving
function
through
MOTS-c-dependent
mechanism,
suggesting
that
may
serve
as
promising
nutraceutical
intervention
Язык: Английский