Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Язык: Английский
The Role of Oxidative Stress in Autism Spectrum Disorder Pathophysiology, Diagnosis and Treatment
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 388 - 388
Опубликована: Фев. 6, 2025
Autism
spectrum
disorder
(ASD)
is
a
significant
health
problem
with
no
known
single
cause.
There
vast
number
of
evidence
to
suggest
that
oxidative
stress
plays
an
important
role
in
this
disorder.
The
author
article
reviewed
the
current
literature
order
summarise
knowledge
on
subject.
In
paper,
investigated
context
its
influence
pathogenesis,
use
biomarkers
as
diagnostic
tools
and
antioxidants
ASD
treatment.
Given
heterogeneity
aetiology
inadequate
treatment
approaches,
search
for
common
metabolic
traits
essential
find
more
efficient
methods.
are
increasing
data
involved
pathogenesis
ASD,
both
directly
through
interplay
inflammation
mitochondrial
dysfunction.
Oxidative
appear
have
good
potential
be
used
aid
early
diagnosis
ASD.
results
most
promising
glutathione
derivatives
also
isoprostanses.
Probably,
complex
dedicated
multi-parametric
panels
may
future.
Antioxidants
show
ASD-supportive
all
described
fields,
support
importance
but
need
further
research,
especially
sample
size
and,
preferably,
multicentre
approach.
Язык: Английский
Detection of an oxidative stress metabolite associated with neurodegenerative diseases: effect of heteroatom doped antioxidant carbon dots
RSC Advances,
Год журнала:
2025,
Номер
15(11), С. 8354 - 8366
Опубликована: Янв. 1, 2025
Carbon
dots
(CDs)
are
neoteric
forms
of
carbon
nanostructures,
and
play
a
fundamental
role
in
early
diagnosis
controlling
neurological
disorders
(NDs).
Язык: Английский
Biophysical characterization of hydrogen sulfide: A fundamental exploration in understanding significance in cell signaling
Biophysical Chemistry,
Год журнала:
2024,
Номер
314, С. 107317 - 107317
Опубликована: Авг. 30, 2024
Язык: Английский
β-Amyloids and Immune Responses Associated with Alzheimer’s Disease
Cells,
Год журнала:
2024,
Номер
13(19), С. 1624 - 1624
Опубликована: Сен. 28, 2024
Alzheimer’s
disease
(AD)
is
associated
with
the
accumulation
of
β-amyloids
(Aβs)
and
formation
Aβ
plaques
in
brain.
Various
structural
forms
isoforms
Aβs
that
have
variable
propensities
for
oligomerization
toxicity
may
differentially
affect
development
AD
been
identified.
In
addition,
there
evidence
are
engaged
complex
interactions
innate
adaptive
immune
systems,
both
which
also
play
a
role
regulation
onset
progression.
this
review,
we
discuss
what
currently
known
about
intricate
interplay
between
response
to
more
in-depth
focus
on
possible
roles
B
cells
pathogenesis
AD.
Язык: Английский