Sodium Selenite Induces Autophagy and Apoptosis in Cervical Cancer Cells via Mitochondrial ROS-Activated AMPK/mTOR/FOXO3a Pathway

Antioxidants, Год журнала: 2024, Номер 13(8), С. 1004 - 1004

Опубликована: Авг. 19, 2024

Selenium (Se) is an essential trace element known for its significant role in maintaining human health and mitigating disease progression. compounds exhibit high selective cytotoxicity against tumor cells. However, their anti-cervical cancer (CC) effects underlying mechanisms have not been fully explored. This study found that sodium selenite (SS) inhibits the viability of HeLa SiHa cells a dose- time-dependent manner. Intraperitoneal injection 3 6 mg/kg SS 14 days female nude mice significantly inhibited growth cell xenografts without evident hepatotoxicity or nephrotoxicity. RNA sequencing results indicated AMP-activated protein kinase (AMPK), Forkhead box O (FOXO), apoptosis signaling pathways are key regulatory SS's anti-CC effects, inhibition proliferation may be related to autophagy ROS-induced apoptosis. Further research has revealed induces through AMPK/mTOR/FOXO3a pathway, characterized by upregulation p-AMPK/AMPK, FOXO3a, LC3-II, cleaved-caspase3, cleaved-PARP downregulation p-mTOR/mTOR p62. Additionally, impaired mitochondrial function, including decreased membrane potential, Ca

Язык: Английский

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Selenium: 48-year journey of global clinical trials

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Язык: Английский

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Spatial Clusters of Low Serum Selenium: the Priorities of Selenium Supplementation to Residents of Keshan Disease Endemic Areas

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Язык: Английский

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Selenium in bread wheat (Triticum aestivum L.) grown in Buenos Aires

Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер unknown, С. 127629 - 127629

Опубликована: Март 1, 2025

Язык: Английский

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In vitro assessment of selenium bioavailability from selenized lactic acid bacteria using a static INFOGEST digestion model and intestinal permeability model

Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер 88, С. 127632 - 127632

Опубликована: Март 8, 2025

Язык: Английский

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Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Abstract With the rising global prevalence of diabetes, rate chronic wounds associated with this disease is also escalating. Although mechanisms underlying trend are not fully understood, accumulating evidence suggests a critical role for reactive oxygen species (ROS). Increased blood glucose levels, bacterial infections, and impaired energy utilization lead to an imbalance between oxidative antioxidant responses, resulting in ROS accumulation. The cellular system can manage small amount ROS; however, excessive exogenous acts upon cell membrane or even penetrates cell, consequently affecting its activity. Excessive cause enhanced expression inflammatory factors, proliferation, vascular vessel damage, extracellular matrix remodeling disturbance, ultimately hindering diabetic wound healing. regulation during healing intricate involves diverse throughout entire wound‐healing process. This review provides systematic overview relationship signaling pathways along most recent strategies targeting these pathways. aim was outline effective mitigating stress provide novel insights into future research.

Язык: Английский

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Editorial Commentary on the Special Issue “Antioxidant Therapy for Cardiovascular Diseases”—Cutting-Edge Insights into Oxidative Stress and Antioxidant Therapy in Cardiovascular Health

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1034 - 1034

Опубликована: Авг. 26, 2024

Recent advances in cardiovascular research have increasingly emphasized oxidative stress as a central mechanism the pathogenesis and progression of diseases [...]

Язык: Английский

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Cytomorphological assessment of the effect of selenium nanoparticles on SPEV-2 oncovirus cells ‎

Journal Of Advanced Pharmacy Education And Research, Год журнала: 2024, Номер 14(1), С. 84 - 90

Опубликована: Янв. 1, 2024

Язык: Английский

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Possible Metabolic Remodeling based on de novo Biosynthesis of L-serine in Se- Subtoxic or Deficient Mammals

Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Preparation and activity study of selenium nanoparticles from polysaccharides of Moringa oleifera leaves

Journal of Food Measurement & Characterization, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Язык: Английский

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