Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 1509 - 1528

Опубликована: Фев. 1, 2025

Abstract: Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in progression of inflammatory diseases. Mitochondria, often referred as "power plants" cell, are essential organelles responsible critical functions such energy metabolism, material synthesis, signal transduction. functional state mitochondria closely linked macrophage polarization, prompting interest strategies that target regulate this process. To end, biomaterials with excellent targeting capabilities effective properties have been developed influence mitochondrial function polarization. However, comprehensive summary biomaterial-driven modulation control phenotypes still lacking. This review highlights polarization discusses mediated by biomaterials, including mitochondria-targeted biomaterials. Finally, prospects challenges use these explored, emphasizing their potential be translated clinic. It anticipated will serve valuable resource materials scientists clinicians development next-generation Keywords: macrophages,

Язык: Английский

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Selenium Mitigates Caerulein and LPS-induced Severe Acute Pancreatitis by Inhibiting MAPK, NF-κB, and STAT3 Signaling via the Nrf2/HO-1 Pathway

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

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Selenium-modified hydroxyapatite titanium coating: enhancing osteogenesis and inhibiting cancer in bone invasion by head and neck squamous cell carcinoma

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 24, 2025

Head and neck squamous cell carcinoma (HNSCC) frequently invades the jaw, surgical treatment often leads to bone defects requiring reconstruction with titanium plates. To enhance anti-tumor regeneration properties of titanium, a selenium-modified hydroxyapatite coating was developed on surfaces. Selenium-modified coatings fabricated using micro-arc oxidation (MAO). The were characterized by SEM, XPS, AFM, Contacting angle test ICP-OES. Cell proliferation assays performed rBMSCs Cal27 cells. osteogenic potential materials assessed via ALP OCN immunofluorescence staining quantitative polymerase chain reaction (qPCR). Apoptosis in cells analyzed through flow cytometry, ROS levels measured fluorescent probes. A successfully formed surface porous structure MAO. atomic percentages calcium, phosphorus selenium 42.47%, 45.43% 12.3%, respectively, ion components could be released steadily slowly. In vitro, 0.2 µg/mL had toxic effects promoted differentiation rBMSCs. PCR showed that increased expression genes related 3-5 times. detection found differences intracellular content between By incorporating coatings, implant can simultaneously promote osteogenesis inhibit tumor growth, offering promising strategy for postoperative functional recovery HNSCC patients.

Язык: Английский

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AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110433 - 110433

Опубликована: Апрель 1, 2025

Язык: Английский

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PLAC1 augments the malignant phenotype of cervical cancer through the mTOR/HIF-1α/snail signaling pathway

Life Sciences, Год журнала: 2024, Номер 359, С. 123242 - 123242

Опубликована: Ноя. 15, 2024

Язык: Английский

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Selenium Ameliorates Aluminum Poisoning-Induced Impaired Production of Neutrophil Extracellular Traps in Chicken

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 15, 2024

Язык: Английский

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