Lactoferrin: current situation and future prospects
Food Bioscience,
Год журнала:
2024,
Номер
unknown, С. 105183 - 105183
Опубликована: Сен. 1, 2024
Язык: Английский
Exploring hypertension-linked diseases: a comprehensive review of innovative drug combinations with enhanced therapeutic potential
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Nutritional Intervention and Musculoskeletal Health in Chronic Kidney Disease
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 896 - 896
Опубликована: Март 4, 2025
Chronic
kidney
disease
(CKD)
is
a
leading
condition
in
terms
of
prevalence
and
overall
health
impact.
With
the
increased
life
expectancy
CKD
population
improvement
medical
care,
controlling
musculoskeletal
complications
remains
tough
challenge.
Patients
with
are
prone
to
falls,
fractures
sarcopenia,
enhancing
risk
death.
A
multitude
mechanisms
contribute
fractures,
treatment
suboptimal;
therefore,
prevention
must
stand
out
as
key
step.
This
review
aims
provide
an
overview
most
relevant
data
regarding
impact
nutrition
on
bone
disorders
sarcopenia
CKD.
The
newest
studies
emphasize
that
plant
protein
intake
associated
lower
production
uremic
toxins,
serum
phosphorus
levels,
stronger
bones.
We
conclude
patients
should
adopt
specific
diets
tailored
presence
osteoporosis,
renal
osteodystrophy,
muscle
wasting.
Low-protein
or
plant-dominant
containing
adequate
amount
could
be
better
choices
for
predialysis
order
protect
their
bones
muscles,
whereas
dialysis
population,
higher
essential
prevent
osteoporosis
sarcopenia.
In
all
CKD,
focusing
antioxidant
food
strong
antiaging
benefit
through
ensuring
good
health.
Язык: Английский
The Role of Antioxidants in Preventing Chronic Kidney Disease Progression: Mechanisms and Clinical Implications
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(2), С. 616 - 630
Опубликована: Март 11, 2025
This
study
aims
to
investigate
the
determinants
of
progression
Chronic
Kidney
Disease
(CKD)
and
role
antioxidant
supplementation
in
managing
oxidative
stress
kidney
function.
The
research
used
a
cross-sectional
with
120
participants,
considering
variables
such
as
age,
gender,
smoking,
family
history,
diet,
alcohol
consumption,
education,
occupation.
Key
findings
from
analysis
were
that
age
was
significant
contributing
factor
CKD
progression,
older
individuals
having
greater
likelihood
developing
advanced
disease
stages.
Males,
particularly
those
hypertension,
had
increased
prevalence
damage.
Smoking
also
found
accelerate
intake
diet
rich
fruits
vegetables
being
associated
high
use.
intervention
group,
supplemented
antioxidants,
evidenced
remarkable
reductions
indicators
well
improvement
function
compared
existing
levels,
shown
by
statistical
comparison
through
Paired
t-tests
Wilcoxon
Signed-Rank
Tests
(p
<
0.05).
control
on
other
hand,
experienced
no
similar
alterations.
In
addition,
multivariable
regression
model
proved
impact
baseline
function,
comorbid
illness
outcomes
poorer
patients
reduced
eGFR.
suggest
lifestyle
modifications
smoking
abstinence
change,
may
have
are
potential
targets
for
clinical
intervention.
highlights
key
influencing
emphasizing
modifiable
risk
factors
like
use,
physical
activity.
Findings
support
crucial
strategies
slowing
improving
renal
health
outcomes.
Язык: Английский
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties
European journal of ecology, biology and agriculture.,
Год журнала:
2025,
Номер
2(2), С. 30 - 46
Опубликована: Март 1, 2025
PFAS
(per-
and
polyfluoroalkyl
substances)
exposure
has
been
linked
to
kidney
damage
through
mechanisms
involving
gut
microbiota
dysbiosis
alterations
in
blood
metabolites.
These
disruptions
trigger
renal
inflammation,
oxidative
stress,
metabolic
dysregulation,
impairing
function.
significantly
alters
microbial
communities,
impacting
metabolites
like
short-chain
fatty
acids
(SCFAs),
bile
acids,
trimethylamine
N-oxide
(TMAO).
imbalances
contribute
chronic
inflammation
fibrosis
the
gut-kidney
axis.
Additionally,
disrupts
related
energy
metabolism,
mitochondrial
function,
lipid
oxidation,
amino
acid
metabolism.
Biomarkers
such
as
uric
acid,
creatinine,
homocysteine
indicate
nephrotoxic
stress.
This
paper
explores
potential
by
which
impact
health
interactions
with
It
also
highlights
its
effects
role
affecting
multiple
body
systems
that
may
involve
various
medical
specialists,
internists,
gastroenterologists,
cardiologists,
obstetricians,
gynecologists,
psychiatrists.
Язык: Английский
Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 409 - 409
Опубликована: Март 28, 2025
Chronic
kidney
disease
(CKD)
is
characterized
by
functional
and
structural
abnormalities,
with
its
progression
strongly
influenced
oxidative
stress
inflammatory
responses,
ultimately
leading
to
renal
fibrosis.
This
study
aimed
investigate
the
effects
of
a
Ganoderma
lucidum
Robinia
pseudoacacia
flower
extract
complex
(NEPROBIN)
through
in
vitro
vivo
experiments.
In
experiments
NRK52E
tubular
epithelial
cells
demonstrated
that
NEPROBIN
significantly
alleviates
H2O2-induced
suppresses
lipopolysaccharide
(LPS)-induced
activation
mitogen-activated
protein
kinase
(MAPK)
nuclear
factor
kappa-light-chain-enhancer
activated
B
(NF-κB)
signaling
pathways.
Additionally,
reduced
LPS-induced
NF-κB
transcriptional
activity
downregulated
expression
cytokines
chemokines
these
cells.
We
further
investigated
vivo.
Kidney
damage
was
induced
mice
using
0.25%
adenine
diet
(AD),
were
orally
treated
at
doses
100,
200,
400
mg/kg/day
for
two
weeks.
treatment
AD-induced
elevations
blood
urea,
serum
creatinine,
urinary
β2-microglobulin
levels.
Markers
notably
lower
kidneys
NEPROBIN-treated
mice.
Furthermore,
effectively
mitigated
response
kidneys,
marked
reduction
cytokine
chemokine
expression.
decrease
inflammation
associated
significant
tubulointerstitial
Overall,
alleviated
fibrosis
directly
targeting
inflammation,
highlighting
potential
as
therapeutic
agent
CKD.
Язык: Английский
Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Ноя. 13, 2024
Maintenance
hemodialysis
(MHD)
patients
are
at
a
higher
risk
of
cardiovascular
disease
(CVD),
common
complication
and
leading
cause
death.
Persistent
micro-inflammation
is
unique
feature
MHD.
Given
the
established
role
inflammation
in
pathogenesis
atherosclerosis,
this
study
aims
to
explore
whether
novel
inflammatory
markers
(inflammation
index)
can
serve
as
independent
factors
for
CVD
MHD
patients.
A
cross-sectional
survey
was
conducted
on
from
three
dialysis
centers,
categorized
into
non-CVD
group
based
medical
history,
laboratory
tests,
physical
examination.
Fasting
blood
samples
were
collected
all
participants
indicator
testing.
The
analysis
209
revealed
that
104
had
concurrent
CVD.
Patients
significantly
older
exhibited
anxiety
depression
scores.
Forward
stepwise
multivariate
logistic
regression
results
identified
index
neutrophil-to-lymphocyte
ratio
(NLR)
(OR
=
1.27,
95%
CI
1.082–1.491,
P
<
0.05)
systemic
immune-inflammation
(SII)
1.001,
1.0001–1.002,
Receiver
operating
characteristic
(ROC)
curve
demonstrated
SII,
platelet-to-lymphocyte
(PLR),
monocyte-to-lymphocyte
(MLR),
NLR
possess
predictive
diagnostic
values
events
patient
population.
Hemodialysis
centers
utilize
simple
cost-effective
proactively
identify
Future
research
how
contributes
required.
Язык: Английский
Phytochemical Screening and Inflammatory Activity Evaluation of Hydroalcoholic Extract of Glycyrrhiza glabra Root
Опубликована: Ноя. 14, 2024
Язык: Английский
SIRT1/NOX1 pathway mediated ameliorative effects of rosmarinic acid in folic acid-induced renal injury
Research in Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(5), С. 622 - 633
Опубликована: Сен. 1, 2024
Renal
injury
is
a
serious
disorder
that
can
be
caused
by
some
diseases
or
agents.
Rosmarinic
acid
(RA)
natural
and
safe
compound
with
powerful
antioxidant
anti-inflammatory
properties.
In
this
study,
the
ameliorative
effects
of
RA
were
assayed
in
folic
(FA)-induced
renal
involving
SIRT1/NOX1
pathway.
Язык: Английский
Association between life’s essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005–2018
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 6, 2024
Background
Hyperuricemia
is
a
significant
risk
factor
for
various
metabolic
and
cardiovascular
conditions.
Life’s
Essential
8
(LE8),
comprehensive
measure
of
health
promoted
by
the
American
Heart
Association,
may
have
protective
role
against
hyperuricemia.
This
study
aims
to
evaluate
association
between
LE8
scores
hyperuricemia
in
representative
sample
US
adults.
Methods
We
conducted
cross-sectional
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2018,
encompassing
26,885
were
calculated
based
on
diet,
physical
activity,
nicotine
exposure,
sleep
health,
body
mass
index,
blood
lipids,
glucose,
pressure.
was
defined
as
serum
uric
acid
levels
≥7.0
mg/dL
men
≥
6.0
women.
Logistic
regression
generalized
additive
models
(GAMs)
used
analyze
relationship
hyperuricemia,
adjusting
potential
confounders.
Results
Higher
significantly
associated
with
lower
odds
(OR
per
10-point
increase:
0.73,
95%
CI:
0.72–0.75,
p
<
0.001).
Stratified
analyses
revealed
consistent
effects
across
subgroups
sex,
age,
race/ethnicity,
PIR
(poverty
income
ratio),
education
level,
drinking
status,
eGFR,
CVD
status.
GAM
both
confirmed
linear
increasing
reduced
risk.
For
example,
males,
OR
0.81
(95%
0.78–0.84),
females,
it
0.66
0.64–0.68).
Conclusion
The
findings
suggest
that
higher
are
robustly
These
results
support
promotion
behaviors
encapsulated
mitigate
Further
studies
needed
explore
causal
pathways
interventions.
Язык: Английский