Association between life’s essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005–2018 DOI Creative Commons
Xiaolan Wang, Jing Fan

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

Background Hyperuricemia is a significant risk factor for various metabolic and cardiovascular conditions. Life’s Essential 8 (LE8), comprehensive measure of health promoted by the American Heart Association, may have protective role against hyperuricemia. This study aims to evaluate association between LE8 scores hyperuricemia in representative sample US adults. Methods We conducted cross-sectional using data from National Health Nutrition Examination Survey (NHANES) 2005–2018, encompassing 26,885 were calculated based on diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, glucose, pressure. was defined as serum uric acid levels ≥7.0 mg/dL men ≥ 6.0 women. Logistic regression generalized additive models (GAMs) used analyze relationship hyperuricemia, adjusting potential confounders. Results Higher significantly associated with lower odds (OR per 10-point increase: 0.73, 95% CI: 0.72–0.75, p < 0.001). Stratified analyses revealed consistent effects across subgroups sex, age, race/ethnicity, PIR (poverty income ratio), education level, drinking status, eGFR, CVD status. GAM both confirmed linear increasing reduced risk. For example, males, OR 0.81 (95% 0.78–0.84), females, it 0.66 0.64–0.68). Conclusion The findings suggest that higher are robustly These results support promotion behaviors encapsulated mitigate Further studies needed explore causal pathways interventions.

Language: Английский

Lactoferrin: current situation and future prospects DOI

Chuanjun Hu,

Libin Chen, Yuanyuan Xia

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105183 - 105183

Published: Sept. 1, 2024

Language: Английский

Citations

4
Exploring hypertension-linked diseases: a comprehensive review of innovative drug combinations with enhanced therapeutic potential DOI

Bhavesh Thakkar,

Hetvi Dadhaniya,

Kiran Dudhat

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
Nutritional Intervention and Musculoskeletal Health in Chronic Kidney Disease DOI Open Access
Diana Moldovan, Crina Claudia Rusu,

Alina Potra

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 896 - 896

Published: March 4, 2025

Chronic kidney disease (CKD) is a leading condition in terms of prevalence and overall health impact. With the increased life expectancy CKD population improvement medical care, controlling musculoskeletal complications remains tough challenge. Patients with are prone to falls, fractures sarcopenia, enhancing risk death. A multitude mechanisms contribute fractures, treatment suboptimal; therefore, prevention must stand out as key step. This review aims provide an overview most relevant data regarding impact nutrition on bone disorders sarcopenia CKD. The newest studies emphasize that plant protein intake associated lower production uremic toxins, serum phosphorus levels, stronger bones. We conclude patients should adopt specific diets tailored presence osteoporosis, renal osteodystrophy, muscle wasting. Low-protein or plant-dominant containing adequate amount could be better choices for predialysis order protect their bones muscles, whereas dialysis population, higher essential prevent osteoporosis sarcopenia. In all CKD, focusing antioxidant food strong antiaging benefit through ensuring good health.

Language: Английский

Citations

0
The Role of Antioxidants in Preventing Chronic Kidney Disease Progression: Mechanisms and Clinical Implications DOI
R. S. Malik,

Suleman Sikander,

Jalil Qadir

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(2), P. 616 - 630

Published: March 11, 2025

This study aims to investigate the determinants of progression Chronic Kidney Disease (CKD) and role antioxidant supplementation in managing oxidative stress kidney function. The research used a cross-sectional with 120 participants, considering variables such as age, gender, smoking, family history, diet, alcohol consumption, education, occupation. Key findings from analysis were that age was significant contributing factor CKD progression, older individuals having greater likelihood developing advanced disease stages. Males, particularly those hypertension, had increased prevalence damage. Smoking also found accelerate intake diet rich fruits vegetables being associated high use. intervention group, supplemented antioxidants, evidenced remarkable reductions indicators well improvement function compared existing levels, shown by statistical comparison through Paired t-tests Wilcoxon Signed-Rank Tests (p < 0.05). control on other hand, experienced no similar alterations. In addition, multivariable regression model proved impact baseline function, comorbid illness outcomes poorer patients reduced eGFR. suggest lifestyle modifications smoking abstinence change, may have are potential targets for clinical intervention. highlights key influencing emphasizing modifiable risk factors like use, physical activity. Findings support crucial strategies slowing improving renal health outcomes.

Language: Английский

Citations

0
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna,

Adina Boulos,

Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Citations

0
Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress DOI Creative Commons
Soyoung Kim, Jeong-Won Kim,

Jonglae Kim

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 409 - 409

Published: March 28, 2025

Chronic kidney disease (CKD) is characterized by functional and structural abnormalities, with its progression strongly influenced oxidative stress inflammatory responses, ultimately leading to renal fibrosis. This study aimed investigate the effects of a Ganoderma lucidum Robinia pseudoacacia flower extract complex (NEPROBIN) through in vitro vivo experiments. In experiments NRK52E tubular epithelial cells demonstrated that NEPROBIN significantly alleviates H2O2-induced suppresses lipopolysaccharide (LPS)-induced activation mitogen-activated protein kinase (MAPK) nuclear factor kappa-light-chain-enhancer activated B (NF-κB) signaling pathways. Additionally, reduced LPS-induced NF-κB transcriptional activity downregulated expression cytokines chemokines these cells. We further investigated vivo. Kidney damage was induced mice using 0.25% adenine diet (AD), were orally treated at doses 100, 200, 400 mg/kg/day for two weeks. treatment AD-induced elevations blood urea, serum creatinine, urinary β2-microglobulin levels. Markers notably lower kidneys NEPROBIN-treated mice. Furthermore, effectively mitigated response kidneys, marked reduction cytokine chemokine expression. decrease inflammation associated significant tubulointerstitial Overall, alleviated fibrosis directly targeting inflammation, highlighting potential as therapeutic agent CKD.

Language: Английский

Citations

0
Inflammatory index is a promising biomarker for maintenance hemodialysis patients with cardiovascular disease DOI Creative Commons

Xi-xi Han,

Huiying Zhang,

Jing-wen Kong

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 13, 2024

Maintenance hemodialysis (MHD) patients are at a higher risk of cardiovascular disease (CVD), common complication and leading cause death. Persistent micro-inflammation is unique feature MHD. Given the established role inflammation in pathogenesis atherosclerosis, this study aims to explore whether novel inflammatory markers (inflammation index) can serve as independent factors for CVD MHD patients. A cross-sectional survey was conducted on from three dialysis centers, categorized into non-CVD group based medical history, laboratory tests, physical examination. Fasting blood samples were collected all participants indicator testing. The analysis 209 revealed that 104 had concurrent CVD. Patients significantly older exhibited anxiety depression scores. Forward stepwise multivariate logistic regression results identified index neutrophil-to-lymphocyte ratio (NLR) (OR = 1.27, 95% CI 1.082–1.491, P < 0.05) systemic immune-inflammation (SII) 1.001, 1.0001–1.002, Receiver operating characteristic (ROC) curve demonstrated SII, platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), NLR possess predictive diagnostic values events patient population. Hemodialysis centers utilize simple cost-effective proactively identify Future research how contributes required.

Language: Английский

Citations

1
Phytochemical Screening and Inflammatory Activity Evaluation of Hydroalcoholic Extract of Glycyrrhiza glabra Root DOI Creative Commons
Amina Tabet Zatla, Amina Hammoudi

Published: Nov. 14, 2024

Language: Английский

Citations

1
SIRT1/NOX1 pathway mediated ameliorative effects of rosmarinic acid in folic acid-induced renal injury DOI Creative Commons

Maryam Mottaghi,

Akram Eidi, Fatemeh Heidari

et al.

Research in Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 622 - 633

Published: Sept. 1, 2024

Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) natural and safe compound with powerful antioxidant anti-inflammatory properties. In this study, the ameliorative effects of RA were assayed in folic (FA)-induced renal involving SIRT1/NOX1 pathway.

Language: Английский

Citations

0
Association between life’s essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005–2018 DOI Creative Commons
Xiaolan Wang, Jing Fan

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 6, 2024

Background Hyperuricemia is a significant risk factor for various metabolic and cardiovascular conditions. Life’s Essential 8 (LE8), comprehensive measure of health promoted by the American Heart Association, may have protective role against hyperuricemia. This study aims to evaluate association between LE8 scores hyperuricemia in representative sample US adults. Methods We conducted cross-sectional using data from National Health Nutrition Examination Survey (NHANES) 2005–2018, encompassing 26,885 were calculated based on diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, glucose, pressure. was defined as serum uric acid levels ≥7.0 mg/dL men ≥ 6.0 women. Logistic regression generalized additive models (GAMs) used analyze relationship hyperuricemia, adjusting potential confounders. Results Higher significantly associated with lower odds (OR per 10-point increase: 0.73, 95% CI: 0.72–0.75, p &lt; 0.001). Stratified analyses revealed consistent effects across subgroups sex, age, race/ethnicity, PIR (poverty income ratio), education level, drinking status, eGFR, CVD status. GAM both confirmed linear increasing reduced risk. For example, males, OR 0.81 (95% 0.78–0.84), females, it 0.66 0.64–0.68). Conclusion The findings suggest that higher are robustly These results support promotion behaviors encapsulated mitigate Further studies needed explore causal pathways interventions.

Language: Английский

Citations

0