Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 7, 2025
Cardiovascular
diseases
represent
the
principal
cause
of
death
and
comorbidity
among
people
with
diabetes.
Ferroptosis,
an
iron-dependent
non-apoptotic
regulated
cellular
characterized
by
lipid
peroxidation,
is
involved
in
pathogenesis
diabetic
cardiovascular
diseases.
The
susceptibility
to
ferroptosis
hearts
possibly
related
myocardial
iron
accumulation,
abnormal
metabolism
excess
oxidative
stress
under
hyperglycemia
conditions.
Accumulating
evidence
suggests
can
be
therapeutic
target
for
This
review
summarizes
ferroptosis-related
mechanisms
novel
choices
targeting
pathways.
Further
study
on
ferroptosis-mediated
cardiac
injury
enhance
our
understanding
pathophysiology
provide
more
potential
choices.
Язык: Английский
Sodium–Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 336 - 336
Опубликована: Март 13, 2025
Redox
(reduction-oxidation)
imbalance
is
a
physiological
feature
regulated
by
well-maintained
equilibrium
between
reactive
oxygen
species
(ROS)
and
oxidative
stress
(OS),
the
defense
system
of
body
(antioxidant
enzymes).
The
redox
comprises
levels
ROS
in
cells,
tissues
overall
organ
system.
are
synchronized
gradients
electrons
that
generated
due
to
sequential
reduction
oxidation
various
biomolecules
enzymes.
Such
reactions
present
each
cell,
irrespective
any
tissue
or
organ.
Failure
such
coordinated
regulation
leads
production
excessive
free
radicals.
Excessively
produced
radicals
affect
cellular
molecular
processes
required
for
cell
survival
growth,
leading
pathophysiological
conditions
and,
ultimately,
failure.
Overproduction
key
factors
involved
onset
progression
associated
with
cardiovascular
renal
diseases.
Sodium-glucose
cotransporter
2
inhibitors
(SGLT2is)
glucose-lowering
drugs
prescribed
diabetic
patients.
Interestingly,
apart
from
their
effect,
these
exhibit
beneficial
effects
non-diabetic
patients
suffering
chronic
kidney
diseases,
perhaps
antioxidant
properties.
Recently,
it
has
been
demonstrated
SGLT2is
strong
properties
reducing
OS.
Hence,
this
review,
we
aim
novel
role
consequent
disease
states.
Язык: Английский
Isopropyl 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoate Alleviates Palmitic Acid-Induced Vascular Aging in HUVEC Cells through ROS/Ferroptosis Pathway
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9278 - 9278
Опубликована: Авг. 27, 2024
Vascular
aging
is
an
important
factor
leading
to
cardiovascular
diseases
such
as
hypertension
and
atherosclerosis.
Hyperlipidemia
or
fat
accumulation
may
play
role
in
vascular
disease.
Isopropyl
3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
(IDHP)
has
biological
activity
can
exert
protection,
which
be
related
ferroptosis.
However,
the
exact
mechanism
remains
undefined.
We
hypothesized
that
IDHP
have
a
protective
effect
on
blood
vessels
by
regulating
caused
hyperlipidemia
wall
accumulation.
The
aim
of
this
study
investigate
palmitic
acid-induced
human
umbilical
vein
endothelial
cells
(HUVEC)
based
senescence
found
could
delay
aging,
reduce
degree
ferrous
ion
lipid
peroxidation,
protect
from
injury.
These
effects
achieved
attenuating
excessive
reactive
oxygen
species
(ROS)
ferroptosis
signaling
pathways
generated
cells.
In
short,
our
identified
one
antioxidant
agents
slow
down
lipotoxicity-induced
through
ROS/ferroptosis
pathway.
new
medicinal
value
provides
therapeutic
idea
for
delaying
patients
with
dyslipidemia.
Язык: Английский