Reevaluating Alzheimer’s disease treatment: Can phytochemicals bridge the therapeutic Gap? DOI
Kasturi Roy, Dinesh Kumar Mehta, Rina Das

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study DOI

Büşra Solak,

Pervin Soyer, Elif Kaya Tilki

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106721 - 106721

Published: Feb. 1, 2025

Language: Английский

Citations

1
NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine DOI Creative Commons
Arian Kola, Filippo Costanti,

Jordan Kahfi

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 525 - 525

Published: April 1, 2025

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by metabolic dysregulation, oxidative stress, amyloid-β (Aβ) aggregation, metal dyshomeostasis, and mitochondrial dysfunction. Current treatments provide only symptomatic relief, highlighting the need for novel therapeutic strategies. This study investigates effects of alkaloids galantamine (GAL) lycorine (LYC) in differentiated SH-SY5Y neuroblastoma cells, an established vitro model AD, which acquire neuronal phenotype upon differentiation. Using untargeted targeted NMR-based metabolomics combined with multivariate statistical analysis, we analyzed extracellular profiles under basal conditions following Aβ42 exposure, both presence absence GAL LYC. Our findings reveal distinct responses to Aβ toxicity, significant alterations pyruvate glutamine metabolism. Both LYC contributed restoration lysine homeostasis, but had more pronounced effect, better sustaining cellular energy balance function. Unlike LYC, treatment was associated accumulation, response between two compounds. These variations may reflect mechanisms action, potentially influencing their roles counteracting Aβ-induced toxicity. highlights value profiling assessing neuroprotective agents reinforces potential natural this context.

Language: Английский

Citations

0
Reevaluating Alzheimer’s disease treatment: Can phytochemicals bridge the therapeutic Gap? DOI
Kasturi Roy, Dinesh Kumar Mehta, Rina Das

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0