Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects

Veterinary Sciences, Год журнала: 2023, Номер 10(1), С. 55 - 55

Опубликована: Янв. 14, 2023

Chronic stress is recognized as a secret killer in poultry. It associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative reactions that damage barrier function of cells lining wall. Poultry, especially genetically selected broiler breeds, frequently suffer these chronic symptoms when exposed multiple stressors their growing environments. Since inflammatory damages are multi-stage long-term processes, overshooting immune down-stream effects also negatively affect animal's microbiota, finally impair its performance commercial value. Means counteract poultry other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids phenolic compounds, known exert anti-inflammatory antioxidant effects. In this review, firstly, main poultry, such heat stress, mycotoxins, dysbiosis diets contain oxidized lipids trigger inflammation, discussed, along key transcription factors involved related signal transduction pathways. Secondly, most promising substances current applications ameliorate highlighted.

Язык: Английский

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AVIAN COCCIDIOSIS: RECENT ADVANCES IN ALTERNATIVE CONTROL STRATEGIES AND VACCINE DEVELOPMENT

Agrobiological Records, Год журнала: 2020, Номер 1, С. 11 - 25

Опубликована: Янв. 1, 2020

Coccidiosis induces huge economic losses to poultry production. Its control through anticoccidial live vaccines and drugs has been very successful with some limitations because of the cost production vaccines, drug resistance, residues representing public health concerns. Consequently, there is a crucial need for drug-free foods. Useful strategies include environmental, immunological, genetic approaches; feed additives are recent attitudes involving probiotics, synbiotics, organic acids, phytobiotics as essential oils, antioxidants, nanobiotics (nanoparticles). A combination such useful trend. Transgenic Eimeria parasite could fill in gap chicken coccidiosis an efficient vaccine improved protective efficacy using multiple antigens. Alternatives justify further studies therapeutic or prophylactic agents. Full biological toxicology profiles promising materials which deserve be applied on larger scale.

Язык: Английский

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Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Toxins, Год журнала: 2024, Номер 16(3), С. 137 - 137

Опубликована: Март 6, 2024

The presence of mycotoxins and their masked forms in chicken feed poses a significant threat to both productivity health. This review examines the multifaceted impacts on various aspects well-being, encompassing efficiency, growth, immunity, antioxidants, blood biochemistry, internal organs. Mycotoxins, toxic substances produced by fungi, can exert detrimental effects even at low levels contamination. hidden or further complicate situation, as they are not easily detected conventional methods but be converted into during digestion. Consequently, chickens exposed mycotoxin-related risks despite apparently mycotoxin levels. consequences exposure include reduced compromised growth rates, impaired immune function, altered antioxidant levels, disturbances biochemical parameters, adverse To mitigate these impacts, effective management strategies essential, such routine monitoring ingredients finished feeds, adherence proper storage practices, implementation detoxification binders. Raising awareness hazards is crucial for safeguarding

Язык: Английский

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Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Antioxidants, Год журнала: 2021, Номер 10(2), С. 186 - 186

Опубликована: Янв. 28, 2021

Redox biology is a very quickly developing area of modern biological sciences, and roles redox homeostasis in health disease have recently received tremendous attention. There are range pairs the cells/tissues responsible for maintenance/regulation. In general, all elements interconnected regulated by various means, including antioxidant vitagene networks. The status maintenance cell signaling stress adaptation. Physiological avian species, poultry, limited attention poorly characterized. However, last 5 years, this topic attracted much attention, publications covered some related aspects. fact, transcription factor Nrf2 was shown to be master regulator defenses via activation vitagenes other protective molecules maintain cells/tissues. It that closely another factor, namely, NF-κB, control inflammation; however, its poultry not yet been Therefore, aim review describe current view on NF-κB functioning with specific emphasis nutritional modulation under conditions. particular, one hand, it has that, many conditions can lead increased synthesis proinflammatory cytokines leading systemic inflammation. On there nutrients/supplements downregulate decrease negative consequences stress-related disturbances homeostasis. vitagene-NF-κB interactions relation balance homeostasis, immunity, gut production await further research.

Язык: Английский

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Food for thought: nano-selenium in poultry nutrition and health

Animal Health Research Reviews, Год журнала: 2020, Номер 21(2), С. 103 - 107

Опубликована: Дек. 1, 2020

Abstract In recent years, nanoparticles have become a fashionable subject of research due to their sizes, shapes, and unique intrinsic physicochemical properties. particular for the last 5 nano-Se has received tremendous attention in terms its production, characteristic, possible application poultry/animal science medical sciences. Indeed, Nano-Se is shown be potential source Se nutrition. However, there an urgent need address questions related absorption, assimilation, metabolism. It not clear at present if major biological effects are Se-protein synthesis, direct antioxidant/prooxidant effects, or both. necessary understand how metallic can converted into H 2 further SeCys incorporated selenoproteins. The aforementioned issues must resolved before finds way animal/poultry production as feed supplement clearly this warrants investigation.

Язык: Английский

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Keratinase improves the growth performance, meat quality and redox status of broiler chickens fed a diet containing feather meal

Poultry Science, Год журнала: 2022, Номер 101(6), С. 101913 - 101913

Опубликована: Апрель 7, 2022

The objective of this study was to assess the effects dietary supplementation keratinase on production broilers fed a diet containing feather meal. A total 162 1-d-old Cobb 500 male broiler (n = 9 cages/diet with 6 chicks/cage) were randomly allocated 3 treatments. corn-soybean-feather meal based (BD), or BD supplemented at 100,000 200,000 U/kg for weeks. Compared control, increased (P < 0.05) body weight gain (3.6-4.3%) and reduced feed conversion ratio (2.4-5.6%) during various experimental periods, also improved apparent tract digestibility ash calcium by 45.0% 8.8%, respectively. Meanwhile, drip loss (29.2%), while pH value (1.6%) 45 min decreased lightness (L* value; 13.6%) (22.1%) pectoral muscle. Moreover, both levels Glutathione peroxidase activity (82.5-87.5%) Malondialdehyde concentration (14.5-18.3%) in In conclusion, can improve performance, meat quality, nutrients, redox status chickens

Язык: Английский

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Oxidation in Poultry Feed: Impact on the Bird and the Efficacy of Dietary Antioxidant Mitigation Strategies

Poultry, Год журнала: 2022, Номер 1(4), С. 246 - 277

Опубликована: Ноя. 7, 2022

Oxidative reactions in premixes or final-compound feed pose considerable challenges to the poultry industry, both terms of rancidity reducing palatability and shelf life vivo oxidative stress negatively impacting animal performance. Whilst there has been broad awareness oxidation for many years, recognition impact on industry grown past twenty years. The appearance woody breast associated muscle meat myopathies led a rapid increase research output reactions. widely demonstrated damage tissue, lipids, DNA, is thought be linked conditions such as leaky gut, coccidiosis, ascites, amongst others. use dietary antioxidants found protect from ameliorate some detrimental effects with stress, including improving performance, increasing antioxidant capacity, mitigating heat transport stress. Therefore, aim this review provide insight into process in-feed summary benefits different kinds well their potential added value, based findings reported within all scientific literature.

Язык: Английский

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Curcumin and curcumin nanoparticles counteract the biological and managemental stressors in poultry production: An updated review

Research in Veterinary Science, Год журнала: 2023, Номер 162, С. 104958 - 104958

Опубликована: Июль 22, 2023

Язык: Английский

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Abiotic stressors in poultry production: A comprehensive review

Journal of Animal Physiology and Animal Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Авг. 12, 2024

Abstract In modern animal husbandry, stress can be viewed as an automatic response triggered by exposure to adverse environmental conditions. This range from mild discomfort severe consequences, including mortality. The poultry industry, which significantly contributes human nutrition, is not exempt this issue. Although genetic selection has been employed for several decades enhance production output, it also resulted in poor resilience. Stress manifested through a series of physiological reactions, such the identification stressful stimulus, activation sympathetic nervous system and adrenal medulla, subsequent hormonal cascades. While brief periods tolerated, prolonged have more consequences. For instance, extreme fluctuations temperature lead accumulation reactive oxygen species, impairment reproductive performance, reduced immunity. addition, excessive noise slaughterhouses linked altered bird behaviour decreased efficiency. Mechanical vibrations shown negatively impact meat quality broilers during transport well egg hatchability hatcheries. Lastly, heavily influenced light intensity regimens, inadequate management result deficiencies, visual anomalies, skeletal deformities, circulatory problems. there growing body evidence demonstrating stressors on physiology, disproportionate representation research. Recent studies focused chronic heat stress, reflecting current interest scientific community climate change. Therefore, review aims highlight major abiotic elucidate their underlying mechanisms, addressing need comprehensive understanding diverse contexts.

Язык: Английский

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Phytogenic feed additives as alternatives to antibiotics in poultry production: A review

Veterinary World, Год журнала: 2025, Номер unknown, С. 141 - 154

Опубликована: Янв. 1, 2025

The overuse of antimicrobials in food-producing animals, particularly poultry, has led to growing concerns about multidrug microbial resistance, posing significant risks both animal and human health. Subtherapeutic doses antibiotics have traditionally been used enhance growth improve economic efficiency poultry farming. However, these practices facilitated the emergence resistant strains, threatening global health security prompting a search for sustainable alternatives. This review highlights significance phytogenic as feed additives (PFAs) promising substitutes antibiotic (AFAs) production. PFAs, derived from plant-based compounds, exhibit multiple beneficial properties, including antimicrobial, antioxidative, anti-inflammatory, immune-modulatory effects. Moreover, they offer potential produce high-quality organic products while reducing likelihood resistance. Despite advantages, inconsistent results among studies underscore importance standardized approaches maximize their efficacy. aims evaluate current status use farming globally, explore properties mechanisms assess viable alternatives antibiotics. By consolidating available knowledge, this provides insights into benefits challenges associated with offering guidance future research practical applications

Язык: Английский

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