Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects

Veterinary Sciences, Journal Year: 2023, Volume and Issue: 10(1), P. 55 - 55

Published: Jan. 14, 2023

Chronic stress is recognized as a secret killer in poultry. It associated with systemic inflammation due to cytokine release, dysbiosis, and the so-called leaky gut syndrome, which mainly results from oxidative reactions that damage barrier function of cells lining wall. Poultry, especially genetically selected broiler breeds, frequently suffer these chronic symptoms when exposed multiple stressors their growing environments. Since inflammatory damages are multi-stage long-term processes, overshooting immune down-stream effects also negatively affect animal's microbiota, finally impair its performance commercial value. Means counteract poultry other animals are, therefore, highly welcome. Many phytogenic substances, including flavonoids phenolic compounds, known exert anti-inflammatory antioxidant effects. In this review, firstly, main poultry, such heat stress, mycotoxins, dysbiosis diets contain oxidized lipids trigger inflammation, discussed, along key transcription factors involved related signal transduction pathways. Secondly, most promising substances current applications ameliorate highlighted.

Language: Английский

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AVIAN COCCIDIOSIS: RECENT ADVANCES IN ALTERNATIVE CONTROL STRATEGIES AND VACCINE DEVELOPMENT

Agrobiological Records, Journal Year: 2020, Volume and Issue: 1, P. 11 - 25

Published: Jan. 1, 2020

Coccidiosis induces huge economic losses to poultry production. Its control through anticoccidial live vaccines and drugs has been very successful with some limitations because of the cost production vaccines, drug resistance, residues representing public health concerns. Consequently, there is a crucial need for drug-free foods. Useful strategies include environmental, immunological, genetic approaches; feed additives are recent attitudes involving probiotics, synbiotics, organic acids, phytobiotics as essential oils, antioxidants, nanobiotics (nanoparticles). A combination such useful trend. Transgenic Eimeria parasite could fill in gap chicken coccidiosis an efficient vaccine improved protective efficacy using multiple antigens. Alternatives justify further studies therapeutic or prophylactic agents. Full biological toxicology profiles promising materials which deserve be applied on larger scale.

Language: Английский

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Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Toxins, Journal Year: 2024, Volume and Issue: 16(3), P. 137 - 137

Published: March 6, 2024

The presence of mycotoxins and their masked forms in chicken feed poses a significant threat to both productivity health. This review examines the multifaceted impacts on various aspects well-being, encompassing efficiency, growth, immunity, antioxidants, blood biochemistry, internal organs. Mycotoxins, toxic substances produced by fungi, can exert detrimental effects even at low levels contamination. hidden or further complicate situation, as they are not easily detected conventional methods but be converted into during digestion. Consequently, chickens exposed mycotoxin-related risks despite apparently mycotoxin levels. consequences exposure include reduced compromised growth rates, impaired immune function, altered antioxidant levels, disturbances biochemical parameters, adverse To mitigate these impacts, effective management strategies essential, such routine monitoring ingredients finished feeds, adherence proper storage practices, implementation detoxification binders. Raising awareness hazards is crucial for safeguarding

Language: Английский

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Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 186 - 186

Published: Jan. 28, 2021

Redox biology is a very quickly developing area of modern biological sciences, and roles redox homeostasis in health disease have recently received tremendous attention. There are range pairs the cells/tissues responsible for maintenance/regulation. In general, all elements interconnected regulated by various means, including antioxidant vitagene networks. The status maintenance cell signaling stress adaptation. Physiological avian species, poultry, limited attention poorly characterized. However, last 5 years, this topic attracted much attention, publications covered some related aspects. fact, transcription factor Nrf2 was shown to be master regulator defenses via activation vitagenes other protective molecules maintain cells/tissues. It that closely another factor, namely, NF-κB, control inflammation; however, its poultry not yet been Therefore, aim review describe current view on NF-κB functioning with specific emphasis nutritional modulation under conditions. particular, one hand, it has that, many conditions can lead increased synthesis proinflammatory cytokines leading systemic inflammation. On there nutrients/supplements downregulate decrease negative consequences stress-related disturbances homeostasis. vitagene-NF-κB interactions relation balance homeostasis, immunity, gut production await further research.

Language: Английский

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Phytogenic feed additives as alternatives to antibiotics in poultry production: A review

Veterinary World, Journal Year: 2025, Volume and Issue: unknown, P. 141 - 154

Published: Jan. 1, 2025

The overuse of antimicrobials in food-producing animals, particularly poultry, has led to growing concerns about multidrug microbial resistance, posing significant risks both animal and human health. Subtherapeutic doses antibiotics have traditionally been used enhance growth improve economic efficiency poultry farming. However, these practices facilitated the emergence resistant strains, threatening global health security prompting a search for sustainable alternatives. This review highlights significance phytogenic as feed additives (PFAs) promising substitutes antibiotic (AFAs) production. PFAs, derived from plant-based compounds, exhibit multiple beneficial properties, including antimicrobial, antioxidative, anti-inflammatory, immune-modulatory effects. Moreover, they offer potential produce high-quality organic products while reducing likelihood resistance. Despite advantages, inconsistent results among studies underscore importance standardized approaches maximize their efficacy. aims evaluate current status use farming globally, explore properties mechanisms assess viable alternatives antibiotics. By consolidating available knowledge, this provides insights into benefits challenges associated with offering guidance future research practical applications

Language: Английский

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Use of Natural Biomolecules in Animal Feed to Enhance Livestock Reproduction

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2328 - 2328

Published: March 5, 2025

Feed additives are crucial in livestock production, enhancing performance, health, and reproductive efficiency. Recently, there has been a shift toward natural biomolecules as feed additives, specifically targeting improved outcomes sperm quality. This transition arises from concerns about antibiotic misuse, antimicrobial resistance, consumer preferences for eco-friendly products, along with the superior bioavailability, lower toxicity, reduced environmental impact of compared to synthetic alternatives. Collaboration among researchers, veterinarians, nutritionists, regulators is essential ensure safe effective management. The review explores advancements using vital processes, including plant-derived bioactives such phytochemicals antioxidants. It investigates not only mechanisms but also intricate interactions these compounds animals' hormonal physiological systems. Additionally, critically assesses challenges prospects related incorporating into practices. potential benefits include enhanced efficiency However, successful implementation requires understanding factors like precise dosing, interactions, long-term health impacts. Overall, this comprehensive highlights recent research, technological strides, future integrating animal diets.

Language: Английский

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Green Tea Polyphenol Epigallocatechin-3-gallate Mediates an Antioxidant Response via Nrf2 Pathway in Heat-Stressed Poultry: A Review

Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 105071 - 105071

Published: March 20, 2025

Heat stress is a critical challenge in the poultry industry. It arises when birds are exposed to elevated ambient temperatures beyond their thermoneutral zone, often exacerbated by high humidity and inadequate ventilation. This condition disrupts birds' ability maintain thermal homeostasis, leading physiological behavioral changes such as increased panting, reduced feed intake, water consumption. These responses aim dissipate heat but result energy imbalances, oxidative stress, impaired immune function. Green tea polyphenols (GTPs) mitigate modulating pathways, primarily scavenging reactive oxygen species (ROS) enhancing antioxidant defense mechanisms. pathways play pivotal role neutralizing ROS generated during inflammation, exposure electrophilic compounds. action helps restore cellular balance enhances overall mechanisms converting harmful free radicals into less molecules, oxygen. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays significant character activation of enzymatic antioxidants network. translocates nucleus upon activation, binds response elements (AREs) promoter regions target genes, upregulates expression key enzymes. Therefore, regulation Nrf2 considered molecular marker mitigating effects its detoxification enzymes, protecting against damage inflammation induced temperatures. exploratory review summarizes anti-oxidative GTPs poultry. highlights cytoprotective basis epigallocatechin-3-gallate (EGCG), particularly Nrf2-mediated which enhance systems protect damage.

Language: Английский

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Use of natural additives: seaweed oil and citrus fiber and effects marinated chicken meat

Food Production Processing and Nutrition, Journal Year: 2025, Volume and Issue: 7(1)

Published: April 7, 2025

Abstract Omega-3 fatty acids, particularly docosahexaenoic acid (DHA), are associated with numerous health benefits. This research was conducted to evaluate the effects of DHA-rich oil from Schizochytrium sp. algae and citrus fiber as a natural alternative sodium tripolyphosphate (STPP) in marinated chicken breast on moisture, drip loss, DHA concentration, shear force, cooking microbiological analysis, consumer sensory attributes. Five hundred sixteen samples were treated, one group received marinade, second untreated (control), third conventional marinade containing chloride, tripolyphosphate, carrageenan (marinade control). Chicken enriched evidenced lower force than control treatments, suggesting an improved tenderness. In addition, significant concentration approximately 230–236 mg/100 g achieved, constant even after six days refrigerated storage. The quality remained satisfactory, total counts mesophilic aerobes below 3 log CFU/g Enterobacteriaceae Pseudomonas spp. 2 CFU/g. A analysis revealed no noticeable differences taste, texture, or overall acceptability control, indicating likely chicken. conclusion, enriching breasts through injection technique offers promising strategy increase omega-3–fatty-acid intake, for individuals insufficient consumption these essential polyunsaturated acids. Graphical

Language: Английский

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Dietary Passion Fruit Seed Oil Supplementation for Health and Performance of Laying Hens

Agriculture, Journal Year: 2025, Volume and Issue: 15(8), P. 864 - 864

Published: April 16, 2025

Passion fruit seed oil (PFSO) is rich in bioactive compounds, which can enhance laying hens’ health and performance. The current study was conducted to investigate the effect of increasing PFSO supplementation productive performance, egg quality, relative weight length organs, plasma lipid oxidation, antioxidant status, gene expression SOD, GPx, CAT, NRF2 liver. One hundred ninety-two 25-week-old Lohmann Whites were randomly divided into three treatments (n = 8 replicates/diet, hens/replicate). groups fed a corn–soybean basal diet containing 0.00%, 0.45%, 0.90% for 16 weeks. results indicated that decreased oxidation 8; linear, p 0.012) increased CAT 0.001). SOD genes tended increase linearly, GPx not affected 4; > 0.05). activity decrease linearly 0.05) by diets. Performance most weight, organs did differ among Therefore, may have positive effects on decreasing oxidative stress, stimulating defense system, sustaining production quality.

Language: Английский

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Effect of Adding Silybum marianum Leaf Extract to Drinking Water on Some Physiological and Histological Parameters of Salmonella-Infected Broiler Liver

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1487(1), P. 012172 - 012172

Published: April 1, 2025

Abstract The experiment was conducted at the College of Agriculture, University Karbala, Department Animal Production, from February 1, 2024, to March 6, 2024. study aimed evaluate effectiveness adding different concentrations ethanolic extract Silybum marianum leaves drinking water on selected physiological and histological parameters liver in broiler chickens infected with Salmonella . used 225 unsexed Ross 308 chicks, through egg injection pathogenic bacteria. chicks were randomly distributed across 15 cages, five experimental treatments, each including 45 birds. Each treatment consisted three replicates, birds per replicate. Chicks allocated into cages (3 birds/cage), grouped by chicks/treatment. replicates (15 birds/replicate). results revealed that levels (p ≤ 0.05) glutathione activity catalase enzyme, significantly higher third, fourth fifth treatments relation first(treatment control) second ones. In addition, found decrease malondialdehyde (MDA) also compared first (control) treatment. reflected decreased ALT AST enzymes groups three, four one two. Furthermore, relevant enhancement recognized 4th 5th than other treatments. It is therefore concluded addition (treatment 4 5) exerted favorable effects (glutathione, cattalase AST) parameters. Results for best between others noticed 3% leaving a level 10 mL litter water.

Language: Английский

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