An update on pathogenesis and clinical scenario for Parkinson’s disease: diagnosis and treatment

3 Biotech, Год журнала: 2023, Номер 13(5)

Опубликована: Апрель 27, 2023

Язык: Английский

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Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties

Antioxidants, Год журнала: 2024, Номер 13(7), С. 762 - 762

Опубликована: Июнь 24, 2024

Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative stress plays crucial role in their development. This paper presents comprehensive analysis of the neuroprotective potential olive oil, with primary focus on its antioxidant properties. The chemical composition including key antioxidants, such as oleuropein, hydroxytyrosol, oleocanthal, is systematically examined. mechanisms by which these compounds provide neuroprotection, counteracting damage modulating pathways, explored. efficacy oil evaluated synthesizing findings from various sources, vitro studies, animal models, clinical trials. integration into dietary patterns, particularly Mediterranean diet, broader implications neurodegenerative disease prevention also discussed. challenges translating preclinical applications acknowledged future research directions proposed better understand mitigating risk conditions. review highlights not only component, but promising candidate preventive neurology, advocating for further investigation context diseases.

Язык: Английский

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Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction

Journal of Neural Transmission, Год журнала: 2024, Номер 131(12), С. 1367 - 1387

Опубликована: Авг. 7, 2024

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like

Язык: Английский

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Correlation of physicochemical properties with antioxidant activity in phenol and thiophenol analogues

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development progression many ailments, such as aging, cardiovascular diseases, Alzheimer's disease, Parkinson's diabetes, cancer, preeclampsia or multiple sclerosis. While phenols polyphenols are most studied antioxidants structurally similar compounds anilines thiophenols sporadically analyzed despite their radical scavenging potential. This work assesses impact structural features on antioxidant activity. Seventeen pairs phenol/thiophenol analogues, possessing both electron-donating withdrawing groups were selected for this study. Several physicochemical properties determined by density functional theory (DFT) calculations at (U)B3LYP/6-311++G(d,p) level gas phase scrf = (smd, solvent water) solvated ones. Correlations between calculated experimental activities investigated identify pivotal physical characteristics contributing efficiency. These include S–H O–H bond distances dissociation enthalpies (BDE), dipole moments, logP values, highest occupied molecular orbital (HOMO) lowest unoccupied (LUMO) energies, HOMO–LUMO gap energies that M06-2X/6-311++G(d,p) theory, Fukui functions. The activity was evaluated using 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) 2,2-diphenyl-1picrylhydrazyl (DPPH) assays. exhibited superior abilities, surpassing reference Trolox. extensive DFT revealed in phase, lower BDE compared IP PA, suggested HAT mechanism predominates case these compound groups. In contrast, water, significant reductions PA due effects SPLET is dominant under aqueous conditions.

Язык: Английский

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Neuroprotective effect of nano-carboxymethyl chitosan from Doryteuthis sibogae against rotenone-induced Parkinson’s Disease in the Zebrafish model

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115523 - 115523

Опубликована: Март 1, 2025

Язык: Английский

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