Effect of COVID-19 Vaccines on Reducing the Risk of Long COVID in the Real World: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(19), С. 12422 - 12422

Опубликована: Сен. 29, 2022

The coronavirus disease 2019 (COVID-19) is still in a global pandemic state. Some studies have reported that COVID-19 vaccines had protective effect against long COVID. However, the conclusions of on COVID were not consistent. This study aimed to systematically review relevant real world, and performed meta-analysis explore relationship between vaccination We searched PubMed, Embase, Web science, ScienceDirect from inception 19 September 2022. PICO (P: patients; I: intervention; C: comparison; O: outcome) was as follows: patients diagnosed with (P); (I); divided into vaccinated unvaccinated groups (C); outcomes occurrence COVID, well various symptoms (O). A fixed-effect model random-effects chosen based heterogeneity order pool value. results showed group 29% lower risk developing compared (RR = 0.71, 95% CI: 0.58-0.87,

Язык: Английский

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Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(23), С. 16010 - 16010

Опубликована: Ноя. 30, 2022

Although many studies of long COVID-19 were reported, there was a lack systematic research which assessed the differences in regard to what unique SARS-CoV-2 strains caused it. As such, this review and meta-analysis aims evaluate characteristics that is by different strains. We systematically searched PubMed, EMBASE, ScienceDirect databases order find cohort as defined WHO (Geneva, Switzerland). The main outcomes determining percentages among patients who infected with Further, study registered PROSPERO (CRD42022339964). A total 51 33,573 included, three possessed Alpha Delta variants, five Omicron variant. highest pooled estimate found CT abnormalities (60.5%; 95% CI: 40.4%, 80.6%) for wild-type strain; fatigue (66.1%; 42.2%, 89.9%) variant; ≥1 general symptoms (28.4%; 7.9%, 49.0%) estimates (65.8%; 47.7%, 83.9%) variant, followed strain, then myalgia variant (11.7%; 95%: 8.3%, 15.1%), compared those strain (9.4%; 6.3%, 12.5%). sleep difficulty lowest (2.5%; 0.2%, 4.9%) when (24.5%; 17.5%, 31.5%) (18.7%; 1.0%, 36.5%). findings suggest no significant difference between has been strains, except certain (i.e., or variant) strain). In context ongoing pandemic its emerging directing more attention well implementing targeted intervention measures address it are vital.

Язык: Английский

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A systematic review and meta‐analysis of long‐term sequelae of COVID‐19 2‐year after SARS‐CoV‐2 infection: A call to action for neurological, physical, and psychological sciences

Journal of Medical Virology, Год журнала: 2023, Номер 95(6)

Опубликована: Июнь 1, 2023

Abstract Long‐term sequelae conditions of COVID‐19 at least 2‐year following SARS‐CoV‐2 infection are unclear and little is known about their prevalence, longitudinal trajectory, potential risk factors. Therefore, we conducted a comprehensive meta‐analysis survivors' health‐related consequences infection. PubMed/MEDLINE, CENTRAL, EMBASE were systematically searched up to February 10, 2023. A systematic review performed calculate the pooled effect size, expressed as event rate (ER) with corresponding 95% confidence interval (CI) each outcome. Twelve studies involving 1 289 044 participants from 11 countries included. total 41.7% survivors experienced one unresolved symptom 14.1% unable return work after The most frequent symptoms investigated findings fatigue (27.4%; CI 17%–40.9%), sleep difficulties (25.1%; 22.4%–27.9%), impaired diffusion capacity for carbon monoxide (24.6%; 10.8%–46.9%), hair loss (10.2%; 7.3%–14.2%), dyspnea (10.1%; 4.3%–21.9%). Individuals severe suffered more anxiety (OR = 1.69, 1.17–2.44) had impairments in forced vital 9.70, 1.94–48.41), lung 3.51, 1.77–6.99), residual volume 3.35, 1.85–6.07) recovery. Existing evidence suggest that higher long‐term older, mostly female, pre‐existing medical comorbidities, status, underwent corticosteroid therapy, inflammation acute Our recovery infection, still suffer either neurological, physical, psychological sequela. These indicate there an urgent need preclude persistent or emerging provide intervention strategies reduce long COVID.

Язык: Английский

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Rehabilitation Interventions for Physical Capacity and Quality of Life in Adults With Post–COVID-19 Condition

JAMA Network Open, Год журнала: 2023, Номер 6(9), С. e2333838 - e2333838

Опубликована: Сен. 19, 2023

Importance Current rehabilitation guidelines for patients with post–COVID-19 condition (PCC) are primarily based on expert opinions and observational data, there is an urgent need evidence-based interventions to support PCC. Objective To synthesize the findings of existing studies that report physical capacity (including functional exercise capacity, muscle function, dyspnea, respiratory function) quality life outcomes following in Data Sources A systematic electronic search was performed from January 2020 until February 2023, MEDLINE, Scopus, CINAHL, Clinical Trials Registry. Key terms were used identify potentially relevant included long-covid , post-covid sequelae therapy activity randomized controlled trial . Study Selection This study clinical trials compared training exercise-based either placebo, usual care, waiting list, or control Extraction Synthesis followed Preferred Reporting Items Systematic Reviews Meta-Analyses. pairwise bayesian random-effects meta-analysis using vague prior distributions. Risk bias assessed Cochrane risk tool version 2, certainty evidence evaluated GRADE system by 2 independent researchers. Main Outcomes Measures The primary outcome measured at closest postintervention time point 6-minute walking test. Secondary fatigue, lower limb life. All defined a priori. Continuous reported as standardized mean differences (SMDs) 95% credible intervals (CrIs) binary summarized odds ratios CrIs. between-trial heterogeneity quantified between-study variance, τ Results Of 1834 identified records, 1193 screened, 14 (1244 patients; 45% female participants; median [IQR] age, 50 [47 56] years) analyses. Rehabilitation associated improvements (SMD, −0.56; CrI, −0.87 −0.22) moderate 7 (389 participants). These had 99% posterior probability superiority when current standard care. value (0.04; 0.00 0.60) indicated low statistical heterogeneity. However, significant uncertainty imprecision regarding experiencing exercise-induced adverse events (odds ratio, 1.68; 0.32 9.94). Conclusions Relevance this review suggest life, high improvement care; other outcomes. Given surrounding safety outcomes, additional enhanced monitoring necessary.

Язык: Английский

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Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

Biomolecules, Год журнала: 2024, Номер 14(7), С. 835 - 835

Опубликована: Июль 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Язык: Английский

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Impact of Rehabilitation on Physical and Neuropsychological Health of Patients Who Acquired COVID-19 in the Workplace

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(2), С. 1468 - 1468

Опубликована: Янв. 13, 2023

Workers, especially healthcare workers, are exposed to an increased risk for SARS-CoV-2 infection. However, less is known about the impact of rehabilitation on health outcomes associated with post-COVID. This longitudinal observational study examined changes in physical and neuropsychological work ability after inpatient 127 patients (97 females/30 males; age 21–69 years; Mean = 50.62) who acquired COVID-19 workplace. Post-COVID symptoms, functional status, performance, health, employment, were assessed before rehabilitation. Group differences relating sex, professions, acute COVID status also analyzed. Except fatigue, prevalence all post-COVID symptoms decreased Significant improvements performance determined. Moreover, workers showed a significantly greater reduction depressive compared non-healthcare workers. Nevertheless, participants reported poor ability, 72.5% them still unable discharge from As most suffering at discharge, ongoing strategies aftercare necessary improve their ability. Further investigations this population 6 12 months should examine further course regarding status.

Язык: Английский

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Physical Activity in Long COVID: A Comparative Study of Exercise Rehabilitation Benefits in Patients with Long COVID, Coronary Artery Disease and Fibromyalgia

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(15), С. 6513 - 6513

Опубликована: Авг. 3, 2023

Exercise in long COVID is poorly studied. Nevertheless, exerciserehabilitation could improve cardiorespiratory, muscular and autonomic functions. We aimed to investigate improvement physical performances of patients (n = 38) after a 4-week exercise rehabilitation program (3 sessions/week) compared two control groups composed coronary artery disease fibromyalgia 38), populations for whom benefits are well known. Efficacy training was assessed by cardiopulmonary test, handgrip force supine heart rate variability recording at rest before the program. Cardiorespiratory parameters were enhanced three (p < 0.001). No significant difference observed variables. Through this comparative study with groups, we confirm reinforce interest caring without post-exertional symptom exacerbation both strength endurance training, personalizing patient symptoms.

Язык: Английский

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Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis

Healthcare, Год журнала: 2022, Номер 10(11), С. 2130 - 2130

Опубликована: Окт. 26, 2022

Background: Many COVID-19 patients presented with detrimental features, such as impaired respiratory function, physical capacity, and overall poor quality of life. The present study evaluates the effectiveness pulmonary rehabilitation on patients. Methods: We searched PubMed, Scopus, ScienceDirect, Google Scholar from 2019 to 2021. protocol was registered in PROSPERO registration number CRD42021273618. performed statistical analyses via random effects expressed outcomes standardized mean difference (SMD) for continuous variables, 95% confidence intervals (CI). Results: included six trials involving 432 primary outcome showed a significant improvement function (SMD 0.83, CI −0.58 1.09; p < 0.001; four trials, 266 participants; high-quality evidence). There anxiety −0.80, −1.23 −0.37; = 0.003), activity intensity levels −1.27, −2.23 −0.32; 0.009), sleep (MD −0.05, −0.83 −0.16; 0.004), peripheral muscle performance lower limbs 0.90, −0.60 1.20; 0.001), dyspnoea −0.55, −0.87 −0.23; 0.007). Conclusions: Pulmonary is an effective adjuvant therapy that minimizes severity intervention group compared conventional treatment. findings this will need be considered framework clinical observed outcome. Additionally, safer data guideline would needed examine whether fruitful reduce severity.

Язык: Английский

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Quality of Life, Fatigue, and Physical Symptoms Post-COVID-19 Condition: A Cross-Sectional Comparative Study

Healthcare, Год журнала: 2023, Номер 11(11), С. 1660 - 1660

Опубликована: Июнь 5, 2023

The magnitude of post-COVID-19 syndrome was not thoroughly investigated. This study evaluated the quality life and persistence fatigue physical symptoms individuals compared with noninfected controls. included 965 participants; 400 had previous COVID-19 disease 565 controls without COVID-19. questionnaire collected data on comorbidities, vaccination, general health questions, symptoms, in addition to validated measures (SF-36 scale), (fatigue severity scale, FSS), dyspnea grade. participants complained more frequently weakness, muscle pain, respiratory voice disorders, imbalance, taste smell loss, menstrual problems Joint tingling, numbness, hypo/hypertension, sexual dysfunction, headache, bowel, urinary, cardiac, visual did differ between groups. Dyspnea grade II–IV significantly groups (p = 0.116). patients scored lower SF-36 domains role 0.045), vitality < 0.001), reported changes mental-components summary 0.014). FSS scores were higher (3 (1.8–4.3) vs. 2.6 (1.4–4); p 0.001). effects could persist beyond acute infection phase. These include life, fatigue, symptoms.

Язык: Английский

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Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(4), С. 1536 - 1536

Опубликована: Фев. 15, 2023

We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well predictors of Long-COVID in a prospective registry. A total 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for clinical follow-up. Among them, 49% experienced fatigue, 38% exertional dyspnea 75% fulfilled criteria Long-COVID. Echocardiography detected reduced global longitudinal strain (GLS) 11% diastolic dysfunction 4%. Magnetic resonance imaging revealed traces pericardial effusion 18% signs former pericarditis or myocarditis Pulmonary function was impaired 11%. Chest computed tomography identified post-infectious residues 22%. Whereas fatigue did not correlate with abnormalities, associated pulmonary (OR 3.6 [95% CI: 1.2-11], p = 0.026), GLS 5.2 1.6-16.7], 0.003) and/or left ventricular 4.2 1.03-17], 0.04). Predictors length in-hospital stay (OR: 1.15 1.05-1.26], 0.004), admission intensive care unit cannot be computed, 0.001) higher NT-proBNP 1.5 1.05-2.14], 0.026). Even 6 discharge, majority While no associations between abnormalities found, correlated function, dysfunction.

Язык: Английский

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