Опубликована: Янв. 1, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2655 - 2655
Опубликована: Фев. 24, 2024
One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial life functions in a global highly synchronized way is communication system called quorum sensing (QS). QS cell-to-cell process that depends on population density mediated by small signalling molecules autoinducers (AIs). In bacteria, controls biofilm formation through regulation gene expression involved extracellular polymeric matrix (EPS) synthesis, virulence factor production, stress tolerance metabolic adaptation. Forming one antimicrobial resistance (AMR). A common feature human pathogens ability form biofilm, which poses serious medical issue due their high susceptibility traditional antibiotics. Because associated with formation, there belief inhibition activity quenching (QQ) may provide alternative therapeutic methods for treating microbial infections. This review summarises recent progress research, focusing biofilms, especially those formed pathogenic become resistant antibiotic treatment. Subsequently, potential approach highlighting innovative non-antibiotic strategies control AMR bacteria has been discussed.
Язык: Английский
Процитировано
24
Life, Год журнала: 2025, Номер 15(1), С. 49 - 49
Опубликована: Янв. 2, 2025
Biofilms, composed of structured communities bacteria embedded in a self-produced extracellular matrix, pose significant challenge due to their heightened resistance antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic within bacterial biofilms, elucidating adaptive strategies employed by microorganisms withstand conventional antimicrobial agents. encompasses role altered gene expression, formation persister cells, contributing recalcitrance biofilms eradication. A comprehensive understanding these provides for exploring innovative therapeutic interventions. study explores promising avenues future research, emphasizing necessity uncovering specific genetic phenotypic adaptations occurring biofilms. The identification vulnerabilities biofilm architecture elucidation key biofilm-specific targets emerge as crucial focal points development targeted strategies. In addressing limitations traditional antibiotics, this discusses approaches. Nanomaterials with inherent properties, quorum-sensing inhibitors disrupting communication, bacteriophages viral agents are highlighted potential alternatives. exploration combination therapies, involving agents, biofilm-disrupting enzymes, immunomodulators, is emphasized enhance efficacy existing treatments overcome resilience.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127861 - 127861
Опубликована: Ноя. 7, 2023
Язык: Английский
Процитировано
33
Deleted Journal, Год журнала: 2024, Номер 2(2), С. 918 - 941
Опубликована: Фев. 5, 2024
After the implantation of dental implants or orthopedic device, there is a "race for surface," competitive battle between bacteria and host cells occupation implant surface. Various antibacterial antibiotic agents have been developed to assist tissue in winning this battle. However, these come with drawbacks, such as potential generate resistance. Metal metal oxide nanoparticles (NPs) demonstrated their versatility, functioning effective antimicrobial coatings, flexible biomaterials both osteoconductive osteoinductive characteristics. In review article will focus on basics infection biofilm formation, followed by discussion resistance, which favors bacteria, strategies reduce NPs expanding role therapeutics be discussed comprehensively. The using that integrate properties osteoinductive/osteoconductive Current advances developments application occupy bulk review, conclude challenges associated NPs.
Язык: Английский
Процитировано
12
Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(3), С. 73 - 73
Опубликована: Март 17, 2024
The cost of treatment antibiotic-resistant pathogens is on the level tens billions dollars at moment. It special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals other healthcare facilities. bacteria can transfer from medical staff contaminated surfaces patients. In paper, we focused our attention antibacterial and antibiofouling activities two types photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) fullerene C60. Detailed atomic force, electrostatic force viscoelastic microscopy revealed topology, nanoelectrical nanomechanical properties used fillers composites. A relationship between electronic structure nanocarbon composites was established. Thorough spectroscopic analysis reactive oxygen species (ROS) generation conducted for both films, it found that them were potent agents against nosocomial (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, epidermis Pseudomonas aeruginosa). Antibiofouling testing indicated CPDs/PU eradicated almost completely biofilms aeruginosa Staphylococcus aureus about 50% Escherichia coli biofilms.
Язык: Английский
Процитировано
11
Archives of Microbiology, Год журнала: 2024, Номер 206(5)
Опубликована: Апрель 14, 2024
Язык: Английский
Процитировано
10
Food Research International, Год журнала: 2024, Номер 190, С. 114650 - 114650
Опубликована: Июнь 15, 2024
Язык: Английский
Процитировано
9
Microbial Pathogenesis, Год журнала: 2024, Номер 188, С. 106543 - 106543
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
8
Antibiotics, Год журнала: 2024, Номер 13(8), С. 788 - 788
Опубликована: Авг. 22, 2024
The growing threat of antimicrobial-resistant (AMR) pathogens to human health worldwide emphasizes the need for more effective infection control strategies. Bacterial and fungal biofilms pose a major challenge in treating AMR pathogen infections. Biofilms are formed by pathogenic microbes encased extracellular polymeric substances confer protection from antimicrobials host immune system. also promote growth antibiotic-resistant mutants latent persister cells thus complicate therapeutic approaches. ubiquitous cause serious risks due their ability colonize various surfaces, including tissues, medical devices, food-processing equipment. Detection characterization crucial prompt intervention control. To this end, traditional approaches often effective, yet they fail identify microbial species inside biofilms. Recent advances artificial intelligence (AI) have provided new avenues improve biofilm identification. Machine-learning algorithms image-processing techniques shown promise accurate efficient detection biofilm-forming microorganisms on biotic abiotic surfaces. These advancements potential transform research clinical practice allowing faster diagnosis tailored therapy. This comprehensive review focuses application AI identification industries, healthcare, food safety, agriculture. discusses existing approaches, challenges, applications research, with particular focus role improving diagnostic capacities guiding preventative actions. synthesis current knowledge future directions, as described review, will guide development efforts combating biofilm-associated
Язык: Английский
Процитировано
8
Food Research International, Год журнала: 2023, Номер 175, С. 113671 - 113671
Опубликована: Ноя. 4, 2023
Язык: Английский
Процитировано
21