This
study
evaluated
the
influence
of
methotrexate
(MTX)
and
non-surgical
periodontal
treatment
(NSPT)
on
composition
oral-gut
microbiota
in
patients
with
rheumatoid
arthritis
(RA).
Assessments
were
performed
at
baseline
(T0),
6
months
after
MTX
(T1),
45
days
NSPT
(T2).
The
oral
gut
was
assessed
by
amplifying
V4
region
16S
gene
from
subgingival
plaques
stools.
results
analysis
continuous
variables
presented
descriptively
non-parametric
tests
adopted.
Thirty-seven
(27
periodontitis)
T0;
32
(24
T1;
28
(17
T2.
Nine
individuals
lost
to
follow-up.
tended
reduce
alpha
diversity
microbiota,
while
appeared
increase
number
different
species
microbiota.
influenced
beta
relative
abundance
directly
status.
did
not
affect
condition
but
modified
interactions
between
clinical
parameters
affected
richness
However,
parameters.
Chronic
periodontitis
is
a
disease
caused
by
several
factors;
therefore,
it
can
be
called
multifactorial
disease.
Such
risk
factors
include
smoking,
diabetes,
genetics,
depression,
and
stress.
Depression
one
of
the
chronic
conditions
with
highest
prevalence
worldwide.
There
evidence
to
support
association
between
psychological
disorders
physiological
behavioral
precursors
caries
periodontal
disease,
suggesting
that
such
connection
may
exist.
Antidepressant
anxiolytic
medication
have
been
associated
decreased
salivary
flow
poor
oral
hygiene.
The
present
study
aimed
examine
local
inflammatory
status
patients
no
other
systemic
depression.
Between
February
2024
March
2024,
we
conducted
this
on
40
aged
20
48,
evaluating
Quigley
Hein
Plaque
Index,
GI
Index
Löe
Silness,
PBI
Index.
Analyzing
obtained
results,
observed
values
parameters,
as
hygiene
index,
gingival
inflammation
papillary
bleeding
were
significantly
higher
in
group
depression
compared
only
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10811 - 10811
Опубликована: Июнь 28, 2023
It
has
been
shown
that
synovial
fibroblasts
(SF)
play
a
key
role
in
the
initiation
of
inflammation
and
joint
destruction,
leading
to
arthritis
progression.
Fibroblasts
may
express
major
histocompatibility
complex
class
II
region
(MHCII)
molecules,
thus,
they
could
be
able
process
present
antigens
immunocompetent
cells.
Here
we
examine
whether
different
types
(synovial,
dermal,
thymic
murine
fibroblasts,
destructive
LS48
noninvasive
NIH/3T3
fibroblasts)
involved
rheumatoid
(RA)
pathogenesis
can
type
collagen
(COL2)-an
autoantigen
associated
with
RA.
Using
panel
MHCII/Aq-restricted
T-cell
hybridoma
lines
specifically
recognize
an
immunodominant
COL2
epitope
(COL2259-273),
found
activate
several
clones
posttranslationally
glycosylated
or
hydroxylated
COL2259-273
epitope.
The
HCQ.3
hybridoma,
which
is
specific
for
259-273
(Gal264),
showed
strongest
response.
Interestingly,
cells,
but
not
synovial,
were
stimulate
other
COL2-specific
hybridomas.
Our
experiments
revealed
are
hybridomas
even
absence
modified
peptide.
mechanism
this
unusual
activation
contact-dependent
involves
receptor
(TCR)
complex.
Diagnostics,
Год журнала:
2024,
Номер
14(17), С. 1972 - 1972
Опубликована: Сен. 6, 2024
The
aim
of
the
study
was
to
collect
data
about
prevalence
and
risk
factors
apical
periodontitis
in
a
population
endodontically
treated
patients.
group
included
151
patients
(52
males,
99
females;
mean
age
48.36
±
15.708
yrs.)
with
391
teeth
(mean
follow-up
5.25
1.759
yrs.).
According
initial
tooth
diagnosis,
root-filled
were
divided
into
Group
A,
for
pulpitis
or
purpose
prosthetic
pulpectomies
(vital
pulp
group),
B,
non-vital
(necrotic
pulp).
Clinical
radiographic
evaluation
root
its
periapical
area
performed
establish
success/failure
endodontic
therapy,
quality
canal
fillings
(length,
density,
taper),
coronal
restoration.
presence
recurrent
caries,
periodontal
pathology,
endo-periodontal
lesions
also
recorded.
Univariate
multivariate
analyses
used
determine
calculate
their
odds
ratios
(ORs).
For
vital
group,
highest
risks
are
associated
inadequate
homogeneity
(OR
30.938),
9.226),
over-filling
8.800).
4.235)
over
60
yrs.
4.875).
necrotic
analysis
identified
an
>
yrs.,
filled
molars,
intracanal
posts,
poor
restoration
quality,
under-filling,
as
significant
combined
factors.
Inadequate
filling
both
groups
most
cases
periodontitis.
Other
include
posts
pulp.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(20), С. 6266 - 6266
Опубликована: Окт. 20, 2024
The
environment
can
alter
the
homeostasis
of
humans
and
human
microbiota.
Oral
health
is
influenced
by
high
altitude
through
symptoms
periodontitis,
barodontalgia,
dental
barotrauma,
a
decrease
in
salivary
flow.
Microbiota
inflammatory
state
are
connected
oral
cavity.
This
study
aimed
to
explore
effect
acute
high-altitude
exposure
on
microbiome
indicators.
يمكن
أن
تؤدي
التغيرات
في
الهرمونات
التي
تحدث
أثناء
فترة
البلوغ
إلى
تفاعل
الخلايا
بشكل
مفرط
مع
المهيجات،
كما
هو
الحال
عند
البالغين
حيث
تتطور
عادات
مفيدة
طويلة
الأمد.
وقد
سلطت
العديد
من
الدراسات
الضوء
على
العلاقة
بين
ضعف
صحة
اللثة
والولادة
المبكرة،
وكذلك
نقص
تنسج
القواطع
المولية
وتجويف
الأسنان،
والاضطراب
العاطفي
الناجم
عن
التجاويف
جانب
التأثير
نوعية
الحياة
واختلال
الأسنان.
تهدف
الدراسة
تقييم
مدى
فعالية
تقنيات
الليزر
الجديدة
تحفيز
وعلاج
التهاب
المرتبط
بالبلوغ،
مقارنة
بالتقنيات
التقليدية.
الاستنتاج
والملخص:
يؤدي
الجمع
العلاج
بالليزر
وتعليمات
نظافة
الفم
تجديد
كامل
لأنسجة
حالات
البلوغ.
This
study
evaluated
the
influence
of
methotrexate
(MTX)
and
non-surgical
periodontal
treatment
(NSPT)
on
composition
oral-gut
microbiota
in
patients
with
rheumatoid
arthritis
(RA).
Assessments
were
performed
at
baseline
(T0),
6
months
after
MTX
(T1),
45
days
NSPT
(T2).
The
oral
gut
was
assessed
by
amplifying
V4
region
16S
gene
from
subgingival
plaques
stools.
results
analysis
continuous
variables
presented
descriptively
non-parametric
tests
adopted.
Thirty-seven
(27
periodontitis)
T0;
32
(24
T1;
28
(17
T2.
Nine
individuals
lost
to
follow-up.
tended
reduce
alpha
diversity
microbiota,
while
appeared
increase
number
different
species
microbiota.
influenced
beta
relative
abundance
directly
status.
did
not
affect
condition
but
modified
interactions
between
clinical
parameters
affected
richness
However,
parameters.
