International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12621 - 12621
Опубликована: Ноя. 24, 2024
The
transcription
factors
c-Myc
and
FoxO3a
play
significant
roles
in
neurodegenerative
processes,
yet
their
interaction
neurological
disorders
remains
largely
unexplored.
In
contrast,
much
of
the
available
information
about
relationship
comes
from
cancer
research.
While
it
is
well-established
that
inhibits
activity,
this
represents
only
a
basic
understanding
far
more
complex
dynamic,
which
includes
exceptions
under
specific
conditions
involvement
additional
regulatory
factors.
Given
critical
need
to
address
gap
for
treatment
prevention
disorders,
review
consolidates
current
knowledge
on
joint
these
two
neuropathology.
It
also
highlights
conformational
flexibility,
post-translational
modifications,
outlines
potential
directions
future
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 8, 2023
Life
expectancy
is
increasing
throughout
the
world
and
coincides
with
a
rise
in
non-communicable
diseases
(NCDs),
especially
for
metabolic
disease
that
includes
diabetes
mellitus
(DM)
neurodegenerative
disorders.
The
debilitating
effects
of
disorders
influence
entire
body
significantly
affect
nervous
system
impacting
greater
than
one
billion
people
disability
peripheral
as
well
cognitive
loss,
now
seventh
leading
cause
death
worldwide.
Metabolic
disorders,
such
DM,
neurologic
remain
significant
challenge
treatment
care
individuals
since
present
therapies
may
limit
symptoms
but
do
not
halt
overall
progression.
These
clinical
challenges
to
address
interplay
between
warrant
innovative
strategies
can
focus
upon
underlying
mechanisms
aging-related
oxidative
stress,
cell
senescence,
death.
Programmed
pathways
involve
autophagy,
apoptosis,
ferroptosis,
pyroptosis
play
critical
role
oversee
processes
include
insulin
resistance,
β-cell
function,
mitochondrial
integrity,
reactive
oxygen
species
release,
inflammatory
activation.
silent
mating
type
information
regulation
2
homolog
1
Cells,
Год журнала:
2023,
Номер
12(22), С. 2595 - 2595
Опубликована: Ноя. 9, 2023
Metabolic
disorders
and
diabetes
(DM)
impact
more
than
five
hundred
million
individuals
throughout
the
world
are
insidious
in
onset,
chronic
nature,
yield
significant
disability
death.
Current
therapies
that
address
nutritional
status,
weight
management,
pharmacological
options
may
delay
but
cannot
alter
disease
course
or
functional
organ
loss,
such
as
dementia
degeneration
of
systemic
bodily
functions.
Underlying
these
challenges
onset
aging
associated
with
increased
lifespan,
telomere
dysfunction,
oxidative
stress
generation
lead
to
multi-system
dysfunction.
These
hurdles
point
urgent
need
underlying
mechanisms
innovative
applications.
New
treatment
strategies
involve
non-coding
RNA
pathways
microRNAs
(miRNAs)
circular
ribonucleic
acids
(circRNAs),
Wnt
signaling,
Wnt1
inducible
signaling
pathway
protein
1
(WISP1)
dependent
upon
programmed
cell
death
pathways,
cellular
metabolic
AMP-activated
kinase
(AMPK)
nicotinamide,
growth
factor
Non-coding
RNAs,
AMPK
cornerstone
for
overseeing
complex
offer
avenues
DM
will
necessitate
continued
appreciation
ability
each
independently
unison
influence
clinical
outcome.
Endocrinology Diabetes & Metabolism,
Год журнала:
2024,
Номер
7(6)
Опубликована: Окт. 7, 2024
There
has
been
a
surge
in
interest
identifying
the
factors
that
impact
cognitive
impairment
(CI)
patients
with
multiple
sclerosis
(MS).
The
purpose
of
our
study
was
to
examine
correlation
between
fasting
blood
sugar
(FBS),
insulin
level,
as
well
sensitivity
and
function
MS.
Sclerosis,
Год журнала:
2024,
Номер
2(2), С. 77 - 87
Опубликована: Март 22, 2024
Cognitive
impairment
is
one
of
the
most
significant
burdens
among
many
neurological
complaints
in
multiple
sclerosis
patients.
deficits
negatively
impact
these
patients’
quality
life,
leading
to
partial
or
total
loss
several
mental
functions,
such
as
learning,
memory,
perception,
problem-solving.
While
precise
mechanisms
involved
onset
and
evolution
cognitive
decline
remain
unknown,
risk
factors
have
been
associated
with
intellectual
disability.
With
increasing
data
on
this
topic
recent
years,
main
aim
review
summarize
relevant
correlated
Firstly,
authors
demonstrate
importance
disability
based
epidemiological
from
patient
cohorts.
Subsequently,
intensely
debated
major
for
are
discussed,
brief
insights
into
pathophysiology
possible
underlying
mechanisms.
Finally,
describe
medication
patients,
highlighting
research
directions
future
studies.
Medical Acupuncture,
Год журнала:
2024,
Номер
36(5), С. 272 - 281
Опубликована: Май 15, 2024
Spasticity
is
a
common
complication
in
patients
with
multiple
sclerosis
(pwMS).
The
present
study
aimed
to
evaluate
the
clinical,
biomechanical,
and
functional
effects
of
dry
needling
(DN)
treating
gastrocnemius
muscle
spasticity
pwMS.
World Journal of Cardiology,
Год журнала:
2024,
Номер
16(11), С. 632 - 643
Опубликована: Окт. 30, 2024
As
a
non-communicable
disease,
cardiovascular
disorders
have
become
the
leading
cause
of
death
for
men
and
women.
Of
additional
concern
is
that
disease
linked
to
chronic
comorbidity
include
nonalcoholic
fatty
liver
(NAFLD).
NAFLD,
also
termed
metabolic-dysfunction-associated
steatotic
greatest
throughout
world,
increasing
in
prevalence
concurrently
with
diabetes
mellitus
(DM),
can
progress
steatohepatitis
leads
cirrhosis
fibrosis.
Individuals
metabolic
disorders,
such
as
DM,
are
more
than
two
times
likely
experience
cardiac
stroke,
includes
NAFLD
when
compared
individuals
without
disorders.
Interestingly,
share
common
underlying
cellular
mechanism
pathology,
namely
silent
mating
type
information
regulation
2
homolog
1
(SIRT1;
