Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Сен. 27, 2023
The
synchronization
of
multiple
oscillators
serves
as
the
central
mechanism
for
maintaining
stable
circadian
rhythms
in
physiology
and
behavior.
Aging
disease
can
disrupt
synchronization,
leading
to
changes
periodicity
activities.
While
our
understanding
clock
under
has
advanced
significantly,
less
is
known
about
its
behavior
outside
which
also
fall
within
a
predictable
domain.
These
states
not
only
impact
stability
but
modulate
period
length.
In
C57BL/6
mice,
aging,
diseases,
removal
peripheral
often
result
lengthened
behavioral
periods.
Here,
we
show
that
these
be
explained
by
surprisingly
simple
mathematical
relationship:
frequency
reciprocal
period,
distribution
becomes
skewed
when
symmetric.
synchronized
population
macroscopic
combined
differ,
accounting
some
atypical
outputs
observed
networks
without
synchronization.
Building
on
this
finding,
investigate
dynamics
context
aging
disease,
where
weakened.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 8, 2023
Life
expectancy
is
increasing
throughout
the
world
and
coincides
with
a
rise
in
non-communicable
diseases
(NCDs),
especially
for
metabolic
disease
that
includes
diabetes
mellitus
(DM)
neurodegenerative
disorders.
The
debilitating
effects
of
disorders
influence
entire
body
significantly
affect
nervous
system
impacting
greater
than
one
billion
people
disability
peripheral
as
well
cognitive
loss,
now
seventh
leading
cause
death
worldwide.
Metabolic
disorders,
such
DM,
neurologic
remain
significant
challenge
treatment
care
individuals
since
present
therapies
may
limit
symptoms
but
do
not
halt
overall
progression.
These
clinical
challenges
to
address
interplay
between
warrant
innovative
strategies
can
focus
upon
underlying
mechanisms
aging-related
oxidative
stress,
cell
senescence,
death.
Programmed
pathways
involve
autophagy,
apoptosis,
ferroptosis,
pyroptosis
play
critical
role
oversee
processes
include
insulin
resistance,
β-cell
function,
mitochondrial
integrity,
reactive
oxygen
species
release,
inflammatory
activation.
silent
mating
type
information
regulation
2
homolog
1
Current Neurovascular Research,
Год журнала:
2023,
Номер
20(3), С. 314 - 333
Опубликована: Июль 25, 2023
Disorders
of
metabolism
affect
multiple
systems
throughout
the
body
but
may
have
greatest
impact
on
both
central
and
peripheral
nervous
systems.
Currently
available
treatments
behavior
changes
for
disorders
that
include
diabetes
mellitus
(DM)
system
diseases
are
limited
cannot
reverse
disease
burden.
Greater
access
to
healthcare
a
longer
lifespan
led
an
increased
prevalence
metabolic
neurodegenerative
disorders.
In
light
these
challenges,
innovative
studies
into
underlying
pathways
offer
new
treatment
perspectives
Alzheimer's
Disease,
Parkinson's
Huntington's
Disease.
Metabolic
intimately
tied
can
lead
debilitating
outcomes,
such
as
multi-nervous
disease,
susceptibility
viral
pathogens,
long-term
cognitive
disability.
Novel
strategies
robustly
address
involve
careful
consideration
cellular
metabolism,
programmed
cell
death
pathways,
mechanistic
target
rapamycin
(mTOR)
its
associated
mTOR
Complex
1
(mTORC1),
2
(mTORC2),
AMP-activated
protein
kinase
(AMPK),
growth
factor
signaling,
risk
factors
apolipoprotein
E
(APOE-ε4)
gene.
Yet,
complex
necessitate
comprehensive
understanding
achieve
clinical
outcomes
susceptibility,
onset,
progression.
Abstract
Alterations
in
the
circadian
system
are
characteristic
of
aging
on
Earth.
With
decline
physiological
processes
due
to
aging,
several
health
concerns
including
vision
loss,
cardiovascular
disorders,
cognitive
impairments,
and
muscle
mass
loss
arise
elderly
populations.
Similar
risks
reported
as
“red
flag”
among
astronauts
during
after
a
long‐term
Space
exploration
journey.
However,
little
is
known
about
common
molecular
alterations
underlying
terrestrial
space‐related
astronauts,
controversial
conclusions
have
been
recently
reported.
In
light
regulatory
role
clock
maintenance
human
health,
we
review
here
overlapping
both
Earth
spaceflight
with
focus
four
most
affected
systems:
visual,
cardiovascular,
central
nervous,
musculoskeletal
systems.
this
review,
briefly
introduce
specific
cellular
followed
by
those
aging.
We
next
summarize
associated
spaceflight,
highlighting
involved
clock‐regulated
genes
space
flown
Drosophila
,
nematodes,
small
mammals,
astronauts.
Finally,
discuss
that
altered
terms
their
expression
spaceflight.
Altogether,
data
elaborated
strengthen
our
hypothesis
regarding
timely
need
include
dysregulation
an
emerging
hallmark
beyond.
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 660 - 660
Опубликована: Фев. 12, 2025
Low
adherence
to
healthy
lifestyle
behaviors
during
pregnancy
and
lactation
is
strongly
associated
with
a
higher
risk
of
childhood
obesity.
This
narrative
review
aims
elucidate
summarize
the
pivotal
role
played
by
physical
activity
(PA)
breastfeeding,
highlighting
potential
mechanisms
linking
PA
in
these
periods
prevention
Maternal
exercise
breastfeeding
significantly
reduces
obesity
enhancing
fetal
metabolism,
supporting
maternal
weight
management,
promoting
improved
practices.
Pregnancy
postpartum
period
represent
critical
windows
for
implementing
preventive
strategies
that
benefit
both
mother
child.
Encouraging
an
active
vital
public
health
strategy
extensive
benefits.
Healthcare
professionals
play
crucial
creating
supportive
environments
providing
tailored
guidance
empower
mothers
engage
regular
PA.
approach
not
only
enhances
individual
outcomes
but
also
contributes
broader
goal
fostering
healthier
communities.
Clinical ophthalmology,
Год журнала:
2025,
Номер
Volume 19, С. 899 - 905
Опубликована: Март 1, 2025
Purpose:
Age-related
macular
degeneration
(AMD)
is
the
leading
cause
of
blindness
in
developed
nations.
Within
retina,
a
subset
cells,
called
melanopsin-containing
intrinsically
photosensitive
retinal
ganglion
cells
,
are
implicated
circadian
rhythms,
prompting
search
for
potential
connection
between
behavior
and
AMD.
Our
objective
was
to
compare
chronotype
(ie,
preference
morning
or
evening
activity)
individuals
with
AMD
that
those
without
ocular
conditions.
Patients
Methods:
The
Horne-Östberg
Morningness-Eveningness
questionnaire
administered
previously
screened
patients
wet
who
received
bilateral
anti–vascular
endothelial
growth
factor
eye
injections
(study
participants)
as
well
pathology
(controls).
Thirty-one
study
participants
19
controls
completed
survey
were
included
analysis.
We
used
Wilcoxon
rank
sum
test
Fisher
exact
continuous
categorical
variables
respectively.
Results:
Study
had
higher
median
age
compared
(83
vs
75,
P
<
0.001).
No
significant
difference
body
mass
index
observed
respondents.
While
disparity
responses
generally
not
statistically
significant,
more
struggled
attending
exercises
7:00
8:00
(45%
21%,
=0.02).
Additionally,
fewer
expressed
need
sleep
before
10:15
pm
(55%
63%,
=0.04).
tended
have
delayed
sleep-wake
cycle.
Conclusion:
In
this
pilot
study,
encountered
greater
challenges
exercise
controls.
Nonetheless,
there
no
could
serve
foundation
extensive
research
exploring
interplay
vision
loss
rhythms.
Plain
Language
Summary:
Researchers
connections
particularly
focusing
on
certain
eye.
This
aimed
daily
activity
preferences
(chronotypes)
identify
their
preference.
Findings
indicated
experienced
prefer
later
bedtimes
Despite
these
trends,
groups.
suggests
may
exhibit
cycle
encounter
difficulties
activities.
However,
further
necessary
fully
understand
relationship
Keywords:
chronotypes,
rhythm,
maculopathy,
surveys
questionnaires
As
a
significant
non-communicable
disease,
cardiovascular
disease
is
the
leading
cause
of
death
for
both
men
and
women,
comprises
almost
twenty
percent
deaths
in
most
racial
ethnic
groups,
can
affect
greater
than
twenty-five
million
individuals
worldwide
over
age
twenty,
impacts
global
economies
with
far-reaching
financial
challenges.
Multiple
factors
onset
that
include
high
serum
cholesterol
levels,
elevated
blood
pressure,
tobacco
consumption
secondhand
smoke
exposure,
poor
nutrition,
physical
inactivity,
obesity,
concurrent
diabetes
mellitus.
Yet,
addressing
any
these
cannot
completely
eliminate
or
progression
disorders.
Novel
strategies
are
necessary
to
target
underlying
mechanisms.
The
silent
mating
type
information
regulation
2
homolog
1
(Saccharomyces
cerevisiae)
(SIRT1),
histone
deacetylase,
limit
injury,
assist
stem
cell
development,
oversee
metabolic
homeostasis
through
nicotinamide
adenine
dinucleotide
(NAD+)
pathways,
foster
trophic
factor
protection,
control
senescence
modulation
telomere
function.
Intimately
tied
SIRT1
pathways
mammalian
forkhead
transcription
(FoxOs)
which
modulate
cardiac
reduce
oxidative
stress,
repair
microcirculation
disturbances,
atherogenesis
autophagy,
apoptosis,
ferroptosis.
AMP
activated
protein
kinase
(AMPK)
also
critical
among
oversight
cellular
metabolism,
insulin
sensitivity,
mitochondrial
function,
inflammation,
susceptibility
viral
infections
such
as
severe
acute
respiratory
syndrome
coronavirus
impact
disease.
relationship
intricate
complex
requires
detailed
insight
successfully
translate
into
clinical
care
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4488 - 4488
Опубликована: Окт. 23, 2023
The
intricate
connection
between
eating
behaviors
and
sleep
habits
is
often
overlooked
in
clinical
practice,
despite
their
profound
interdependence.
Sleep
plays
a
key
role
modulating
psychological,
hormonal
metabolic
balance
exerting
an
influence
on
food
choices.
Conversely,
various
disorders
may
affect
continuity,
sometimes
promoting
the
development
of
pathologies.
Neurologists,
nutritionists
psychiatrists
tend
to
focus
these
issues
separately,
resulting
failure
recognize
full
extent
conditions.
This
detrimental
separation
can
lead
underestimation,
misdiagnosis
inappropriate
therapeutic
interventions.
In
this
review,
we
aim
provide
comprehensive
understanding
tangled
relationship
sleep,
pathologies
disorders,
by
incorporating
perspective
experts,
psychologists
psychiatrists.
Our
goal
identify
practical
crossroad
integrating
expertise
all
involved
specialists.
Chronobiology International,
Год журнала:
2024,
Номер
41(8), С. 1226 - 1236
Опубликована: Июль 22, 2024
Breast
milk
provides
numerous
benefits
for
both
the
baby
and
mother,
making
it
a
unique
valuable
food.
The
World
Health
Organization
United
Nations
International
Children's
Emergency
Found
(UNICEF)
state
that
exclusive
breastfeeding
in
first
six
months
of
life
is
an
important
strategy
reducing
mortality
morbidity
infants.
circadian
rhythm
formation,
which
starts
mother's
womb,
continues
after
born.
plays
active
role
regulating
baby's
through
hormones,
basic
immune
factors
bioactive
components
contains,
as
well
meeting
almost
all
nutritional
elements
babies.
Since
neural
control
mechanisms
newborn
are
not
yet
fully
developed,
breast
undertakes
task
helping
biological
rhythms
regulation
infant's
sleep-wake
cycles,
thanks
to
some
its
composition.
There
studies
showing
contains
high
levels
cortisol
amino
acids
promote
activity
during
day,
while
night
has
melatonin
tryptophan,
micronutrients
vary
throughout
day.
A
better
understanding
displayed
by
composition
improving
maternal
infant
health.
there
many
affecting
milk,
recommended
should
be
done
on
country
or
regional
basis,
policies
can
developed
result
results
obtained.
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2451 - 2451
Опубликована: Июль 28, 2024
It
is
the
purpose
of
this
review
to
compare
differences
in
postnatal
epigenetic
programming
at
level
DNA
and
RNA
methylation
later
obesity
risk
between
infants
receiving
artificial
formula
feeding
(FF)
contrast
natural
breastfeeding
(BF).
FF
bears
aberrant
enhances
expression
demethylase
fat
mass-
obesity-associated
gene
(FTO),
pointing
further
deviations
methylome.
Based
on
a
literature
search
through
Web
Science,
Google
Scholar,
PubMed
databases
concerning
dietary
factors
influencing
FTO
protein
activity,
FTO’s
impact
adipogenic
was
investigated.
Accumulated
translational
evidence
underscores
that
total
intake
as
well
tryptophan,
kynurenine,
branched-chain
amino
acids,
milk
exosomal
miRNAs,
NADP,
NADPH
are
crucial
regulators
modifying
activity.
Increased
FTO-mTORC1-S6K1
signaling
may
epigenetically
suppress
WNT/β-catenin
pathway,
enhancing
adipocyte
precursor
cell
proliferation
adipogenesis.
Formula-induced
FTO-dependent
alterations
N6-methyladenosine
(m6A)
methylome
represent
novel
unfavorable
molecular
events
development
adipogenesis
obesity,
necessitating
investigations.
BF
provides
physiological
regulation,
compelling
reason
rely
BF.
