Therapeutic potential of AMPK signaling targeting in lung cancer: Advances, challenges and future prospects

Life Sciences, Год журнала: 2021, Номер 278, С. 119649 - 119649

Опубликована: Май 24, 2021

Язык: Английский

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Interplay between SOX9 transcription factor and microRNAs in cancer

International Journal of Biological Macromolecules, Год журнала: 2021, Номер 183, С. 681 - 694

Опубликована: Май 3, 2021

Язык: Английский

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Gene regulation by antisense transcription: A focus on neurological and cancer diseases

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 145, С. 112265 - 112265

Опубликована: Ноя. 8, 2021

Advances in high-throughput sequencing over the past decades have led to identification of thousands non-coding RNAs (ncRNAs), which play a major role regulating gene expression. One emerging class ncRNAs is natural antisense transcripts (NATs), RNA molecules transcribed from opposite strand protein-coding locus. NATs are known concordantly and discordantly regulate expression both cis trans manners at transcriptional, post-transcriptional, translational, epigenetic levels. Aberrant can therefore cause dysregulation many biological pathways has been observed genetic diseases. This review outlines involvements mechanisms pathogenesis various diseases, with special emphasis on neurodegenerative diseases cancer. We also summarize recent findings NAT knockdown and/or overexpression experiments discuss potential as promising targets for future therapies.

Язык: Английский

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Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies

Life Sciences, Год журнала: 2021, Номер 288, С. 119948 - 119948

Опубликована: Сен. 11, 2021

Язык: Английский

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Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions

Cellular Signalling, Год журнала: 2022, Номер 94, С. 110323 - 110323

Опубликована: Март 29, 2022

Язык: Английский

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