Reproductive Biology and Endocrinology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 26, 2023
Autophagy
is
a
highly
conserved,
lysosome-dependent
biological
mechanism
involved
in
the
degradation
and
recycling
of
cellular
components.
There
growing
evidence
that
autophagy
related
to
male
reproductive
biology,
particularly
spermatogenic
endocrinologic
processes
closely
associated
with
sexual
health.
In
recent
decades,
problems
such
as
decreasing
sperm
count,
erectile
dysfunction,
infertility
have
worsened.
addition,
health
overall
comorbidity
aging
men.
this
review,
we
will
outline
role
new
player
dysfunction
prostate
cancer.
We
first
provide
an
overview
mechanisms
its
regulating
cells.
then
focus
on
link
between
aging-related
diseases.
This
followed
by
discussion
therapeutic
strategies
targeting
before
end
limitations
current
studies
suggestions
for
future
developments
field.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Июнь 28, 2022
Abstract
Cancer
is
one
of
the
leading
causes
death
worldwide,
and
factors
responsible
for
its
progression
need
to
be
elucidated.
Exosomes
are
structures
with
an
average
size
100
nm
that
can
transport
proteins,
lipids,
nucleic
acids.
This
review
focuses
on
role
exosomes
in
cancer
therapy.
We
discuss
how
able
modulate
components
tumor
microenvironment
influence
proliferation
migration
rates
cells.
also
highlight
that,
depending
their
cargo,
suppress
or
promote
cell
enhance
reduce
response
radio-
chemo-therapies.
In
addition,
we
describe
trigger
chronic
inflammation
lead
immune
evasion
by
focusing
ability
transfer
non-coding
RNAs
between
cells
other
molecular
signaling
pathways
such
as
PTEN
PI3K/Akt
cancer.
Subsequently,
use
carriers
anti-tumor
agents
genetic
tools
control
progression.
then
tumor-derived
carcinogenesis.
Finally,
devote
a
section
study
diagnostic
prognostic
clinical
courses
important
treatment
patients.
provides
comprehensive
understanding
therapy,
therapeutic
value
remodeling
microenvironment.
Graphical
Journal of Controlled Release,
Год журнала:
2022,
Номер
351, С. 50 - 80
Опубликована: Сен. 20, 2022
The
site-specific
delivery
of
antitumor
agents
is
importance
for
providing
effective
cancer
suppression.
Poor
bioavailability
anticancer
compounds
and
the
presence
biological
barriers
prevent
their
accumulation
in
tumor
sites.
These
obstacles
can
be
overcome
using
liposomal
nanostructures.
challenges
chemotherapy
stimuli-responsive
nanocarriers
are
first
described
current
review.
Then,
liposomes
including
pH-,
redox-,
enzyme-,
light-,
thermo-
magneto-sensitive
nanoparticles
discussed
potential
drugs
emphasized.
pH-
or
redox-sensitive
based
on
internal
stimulus
release
drug
response
to
a
mildly
acidic
pH
GSH,
respectively.
pH-sensitive
mediate
endosomal
escape
via
proton
sponge.
multifunctional
responsive
both
redox
have
more
capacity
at
site
compared
alone.
magnetic
field
NIR
irradiation
exploited
external
stimulation
liposomes.
light-responsive
when
they
exposed
irradiation;
thermosensitive-liposomes
temperature
>40
°C
there
hyperthermia;
magneto-responsive
field.
smart
nanoliposomes
also
co-delivery
genes
synergistic
therapy.
Due
lack
long-term
toxicity
liposomes,
utilized
near
future
treatment
patients.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Авг. 17, 2022
Cancer
is
one
of
the
most
frequently
diagnosed
malignant
diseases
worldwide,
posing
a
serious,
long-term
threat
to
patients’
health
and
life.
Systemic
chemotherapy
remains
first-line
therapeutic
approach
for
recurrent
or
metastatic
cancer
patients
after
surgery,
with
potential
effectively
extend
patient
survival.
However,
development
drug
resistance
seriously
limits
clinical
efficiency
ultimately
results
in
treatment
failure
death.
A
large
number
studies
have
shown
that
non-coding
RNAs
(ncRNAs),
particularly
microRNAs,
long
RNAs,
circular
are
widely
involved
regulation
resistance.
Their
dysregulation
contributes
by
modulating
expression
specific
target
genes
cellular
apoptosis,
autophagy,
efflux,
epithelial-to-mesenchymal
transition
(EMT),
stem
cells
(CSCs).
Moreover,
some
ncRNAs
also
possess
great
as
efficient,
biomarkers
diagnosis
prognosis
well
targets
patients.
In
this
review,
we
summarize
recent
findings
on
emerging
role
underlying
mechanisms
focus
their
applications
treatment.
This
information
will
be
benefit
early
prognostic
assessments
ncRNA-based
strategies
