Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Biomolecules, Год журнала: 2022, Номер 12(3), С. 371 - 371

Опубликована: Фев. 25, 2022

Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology these disorders is not well known; however, environmental, molecular, genetic influences play a major role in pathogenesis Using disease (AD) as archetype, pathological findings include aggregation Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), cerebrovascular dysregulation. This review highlights neuroinflammatory neuroprotective epigallocatechin-3-gallate (EGCG): medicinal component green tea, known nutraceutical that has shown promise modulating AD progression due to its antioxidant, anti-inflammatory, anti-aging abilities. report also re-examines current literature provides innovative approaches for EGCG be used preventive measure alleviate other disorders.

Язык: Английский

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Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson’s disease

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115788 - 115788

Опубликована: Окт. 31, 2023

Parkinson's Disease (PD), a neurodegenerative disorder, is characterized by the degeneration of progressive dopaminergic (DA) neurons in substantia nigra region human midbrain. Although just what causes PD remains mystery, it known that oxidative stress (OS) as well mitochondrial dysfunction, neuro-inflammation, and insufficient neurotrophic support play role disease's pathophysiology. Phytochemicals are diverse small molecule group derived from plants can be classified into numerous classes on basis their biological activities chemical structure. Of these groups phytochemicals, most abundant, which has well-established anti-Parkinson's effects, polyphenols. Flavonoids, including naringin naringenin, genistein, kaempferol, anthocyanins, epigallocatechin-3-gallate, baicalein plant-based biologically active polyphenols, have been shown to exhibit therapeutic potential when used treatment for variety pathological illnesses, such diseases (NDs) PD. Recently, was reported flavonoids beneficial effects PD, protection DA neurons, improvement motor cognitive abilities, regulation signaling pathways, modulation OS neuro-inflammation. In addition, changing composition bacteria gut microbiota, reduce pathogenic strains promote growth strains. this context, current paper will provide literature review neurological roles play, one abundant phytochemical families,

Язык: Английский

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Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2258 - 2258

Опубликована: Янв. 23, 2023

Depressive disorders can affect up to 350 million people worldwide, and in developed countries, the percentage of patients with depressive may be as high 10%. During depression, activation pro-inflammatory pathways, mitochondrial dysfunction, increased markers oxidative stress, a reduction antioxidant effectiveness body are observed. It is estimated that approximately 30% depressed do not respond traditional pharmacological treatments. However, more attention being paid influence active ingredients food on course risk neurological disorders, including depression. The possibility using foods containing polyphenols an element diet therapy depression was analyzed review. whether consumption products such could alleviate or prevent progression it also considered. Results from preclinical studies demonstrate potential phenolic compounds have reduce behaviors by regulating factors related neuroinflammation, modulation intestinal microbiota.

Язык: Английский

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Epigallocatechin 3-gallate-induced neuroprotection in neurodegenerative diseases: molecular mechanisms and clinical insights

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Neurodegenerative diseases (NDs) are caused by progressive neuronal death and cognitive decline. Epigallocatechin 3-gallate (EGCG) is a polyphenolic molecule in green tea as neuroprotective agent. This review evaluates the therapeutic effects of EGCG explores molecular mechanisms that show its properties. protects neurons several ways, such lowering oxidative stress, stopping Aβ from aggregation together, changing cell signaling pathways, decreasing inflammation. Furthermore, it promotes autophagy improves mitochondrial activity, supporting survival. Clinical studies have demonstrated supplementation can reduce neurodegenerative biomarkers enhance function. provides insights into potential treating various NDs. reduces stress scavenging free radicals enhancing antioxidant enzyme aiding defense. It also abilities inhibiting toxicity peptides. changes important pathways like Nrf2, PI3K/Akt, MAPK, which necessary for survival, death, Additionally, has strong anti-inflammatory properties because inhibits microglial activation downregulates pro-inflammatory cytokines. function reducing increasing ATP synthesis, promoting biogenesis, neurons’ survival energy metabolism. In addition, triggers autophagy, cellular process breaks down recycles damaged proteins organelles, eliminating neurotoxic aggregates maintaining homeostasis. Moreover, holds significant promise an ND treatment, but future research should focus on bioavailability understanding long-term clinical effects. Future improving delivery settings. potentially be agent managing NDs, indicating need further research.

Язык: Английский

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Therapeutic Insights on Ferroptosis in Parkinson's disease

European Journal of Pharmacology, Год журнала: 2022, Номер 930, С. 175133 - 175133

Опубликована: Июль 2, 2022

Язык: Английский

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Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

Ageing Research Reviews, Год журнала: 2022, Номер 79, С. 101658 - 101658

Опубликована: Июнь 2, 2022

Язык: Английский

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Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits

Molecules, Год журнала: 2022, Номер 27(21), С. 7604 - 7604

Опубликована: Ноя. 6, 2022

Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the globe. They are mainly characterized by modified protein accumulation that might trigger various biological responses, including oxidative stress, inflammation, regulation of signaling pathways, and excitotoxicity. These disorders have been widely studied during last decade in hopes developing symptom-oriented therapeutics. However, no definitive cure has yet discovered. Tea is one world’s most popular beverages. The same plant, Camellia Sinensis (L.).O. Kuntze, used to make green, black, oolong teas. Green tea thoroughly because its anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, neuroprotective properties. beneficial effect consumption on neurodegenerative reported several human interventional observational studies. polyphenolic compounds found green tea, known as catechins, demonstrated many therapeutic effects. can help preventing and, somehow, treating diseases. Catechins show anti-inflammatory well antioxidant effects via blocking cytokines’ excessive production inflammatory chelating metal ions free radical scavenging. may inhibit tau phosphorylation, amyloid beta aggregation, release apoptotic proteins. also lower alpha-synuclein levels boost dopamine levels. All these factors potential affect disorders. This review will examine catechins’ highlighting their biological, pharmacological, antioxidant, chelation abilities, with a focus ability activate diverse cellular pathways brain. points out mechanisms catechins cognitive diseases, Alzheimer’s, Parkinson’s, multiple sclerosis, deficit.

Язык: Английский

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Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson’s disease

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Сен. 12, 2022

Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from green tea extract, possesses versatile bioactivities that can combat many diseases. During the last decade, EGCG was shown to be effective in experimental models of Parkinson's disease (PD). Several studies have suggested it has pleiotropic neuroprotective effects, which enhanced appeal as a therapeutic strategy PD. In this review, we compiled recent updates and knowledge molecular mechanisms underlying effects We focused on apoptosis, oxidative stress, inflammation, ferroptosis, modulation dopamine production, aggregation α-synuclein. The review highlights pharmacological features its implications Taken together, accumulated data indicate is promising compound for treatment

Язык: Английский

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Special tea products featuring functional components: Health benefits and processing strategies

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2023, Номер 22(3), С. 1686 - 1721

Опубликована: Март 1, 2023

Abstract The functional components in tea confer various potential health benefits to humans. To date, several special products featuring (STPFCs) have been successfully developed, such as O ‐methylated catechin‐rich tea, γ‐aminobutyric acid‐rich low‐caffeine and selenium‐rich products. STPFCs some unique enhanced when compared with conventional products, which can meet the specific needs preferences of different groups huge market potential. processing strategies improve by regulating component content an active area research food science. fresh leaves varieties rich are used raw materials, technologies employed prepare STPFCs. Huge progress has achieved development these However, current status not yet systematically reviewed. Here, studies on comprehensively reviewed a focus their strategies. Additionally, other chemical be developed into teas application industry discussed. Finally, suggestions promises challenges for future study provided. This paper might shed light Future should screening varieties, identifying new components, evaluating health‐promoting effects, improving flavor quality, elucidating interactions between components.

Язык: Английский

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Efficient inhibition of amyloid fibrillation and cytotoxicity of α-synuclein and human insulin using biosynthesized silver nanoparticles decorated by green tea polyphenols

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 16, 2024

Abstract Green tea polyphenols (GTPs), particularly epigallocatechin-3-gallate, stand out among natural small molecules screened for their ability to target protein aggregates due potent anti-amyloidogenic and neuroprotective activities against various disease-related peptides proteins. However, the clinical applications of GTPs in amyloid-related diseases have been greatly limited by drawbacks such as poor chemical stability low bioavailability. To address these limitations, this study utilized an Iranian green polyphenolic extract a reducing agent neutralize silver ions facilitate formation nanoparticle capped (GTPs-capped AgNPs). The results obtained from demonstrate that GTPs-capped AgNPs are more effective than free at inhibiting amyloid fibrillation cytotoxicity induced fibrils human insulin α-synuclein (α-syn). This improved efficacy is attributed increased surface/volume ratio AgNPs, which can enhance binding affinity amyloidogenic species boosts antioxidant activity. mechanism inhibit appears vary depending on protein. For structured insulin, hinder constraining its native-like state. In contrast, modulate intrinsically disordered proteins like α-syn redirecting aggregation pathway towards non-toxic off-pathway oligomers or amorphous aggregates. These findings highlight polyphenol-functionalized nanoparticles promising strategy targeting associated with neurodegenerative diseases.

Язык: Английский

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