Micro/nanosystems for controllable drug delivery to the brain

The Innovation, Год журнала: 2023, Номер 5(1), С. 100548 - 100548

Опубликована: Ноя. 27, 2023

•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.

Язык: Английский

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Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(26)

Опубликована: Авг. 4, 2023

Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting

Язык: Английский

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Niosomes for nose-to-brain delivery: A non-invasive versatile carrier system for drug delivery in neurodegenerative diseases

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105007 - 105007

Опубликована: Сен. 28, 2023

Язык: Английский

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Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

RSC Advances, Год журнала: 2024, Номер 14(15), С. 10608 - 10637

Опубликована: Янв. 1, 2024

This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Язык: Английский

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Targeting Vascular Destruction by Sonosensitizer‐Free Sonocatalytic Nanomissiles Instigates Thrombus Aggregation and Nutrition Deprivation to Starve Pancreatic Cancer

Advanced Functional Materials, Год журнала: 2024, Номер 34(30)

Опубликована: Март 22, 2024

Abstract Sonosensitizers in current sonodynamic therapy (SDT) often suffer from poor delivery efficiency, phototoxicity, and disputed safety. To overcome these issues, a sonosensitizers‐free sonocatalytic nanomissile is constructed, wherein PLGA nanoparticles as vehicles conjugate with L‐arginine (LA) aptamer XQ2d capable of adsorbing CO 2 targeting CD71‐overexpressed pancreatic cancer, respectively. The adsorbed can respond to acidic tumor microenvironment local ultrasound release bubbles enhance ultrasound‐triggered inertial cavitation, which further split H O activate dissolved produce ·OH 1 , respectively, unlocking the ROS birth. Moreover, such bubbles‐enhanced cavitation also target intratumoral vascular destruction, instigate thrombus aggregation, induce nutrition oxygen deprivation, pose hypoxia alter metabolism, thus establishing an destruction‐targeted starvation therapy. strategy different previous presence undamaged blood vessels compromises their outcomes. Especially, active allows more sonosensitizer‐free nanomissiles retain significantly magnifying against subcutaneous orthotopic cancers. Therefore, research provides promising route therapeutic platform for clinical cancer

Язык: Английский

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Ginkgo biloba extract-loaded PLGA microcapsules generated from microfluidics for Alzheimer's disease treatment

Materials & Design, Год журнала: 2024, Номер 238, С. 112735 - 112735

Опубликована: Фев. 1, 2024

Boosting the birth rate of new neurons in adult hippocampus is a possible treatment method for management Alzheimer's disease (AD). Recent studies have revealed that Ginkgo biloba extract (GBE) can act as neuroprotective agent to prevent memory loss variety neurodegenerative illnesses. However, low bioavailability and short half-life active components vivo limit their application. Here, we describe class microcapsules (MPs) sustained GBE delivery gelatin methacrylate (GelMa) cores poly(L-lactide-co-glycolide) (PLGA) shells. The encapsulated was slowly released from solidified MPs during degradation polymer. In addition, showed good biocompatibility cell experiments. When GelMa-PLGA containing were applied APP/PS1 mice, amyloid deposition mouse brain reduced, cognitive impairment improved. These results indicate GBE-encapsulated potential clinical value treating AD other diseases.

Язык: Английский

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Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Neuronanomedicine harnesses nanoparticle technology for the treatment of neurological disorders. An unavoidable consequence delivery to biological systems is formation a protein corona on surface. Despite well-established influence behavior and fate, as well FDA approval neuro-targeted nanotherapeutics, effect physiologically relevant nanoparticle-brain cell interactions insufficiently explored. Indeed, less than 1% studies have investigated coronas formed in cerebrospinal fluid (CSF), surrounding brain. Herein, we utilize two clinically polymeric nanoparticles (PLGA PLGA-PEG) evaluate serum CSF coronas. LC-MS analysis revealed distinct compositions, with selective enrichment/depletion profiles. Enhanced association precoated particles brain cells demonstrates importance selecting fluids more accurately study subsequent nanoparticle-cell interactions, paving way improved engineering vivo applications.

Язык: Английский

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Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors

Biomaterials, Год журнала: 2025, Номер 319, С. 123180 - 123180

Опубликована: Фев. 13, 2025

Язык: Английский

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Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights

Brain Research Bulletin, Год журнала: 2022, Номер 193, С. 11 - 21

Опубликована: Ноя. 23, 2022

Alzheimer's disease (AD) is the most devastating neurodegenerative disorder affecting elderly. The exact pathology of AD not yet fully understood and several hallmarks such as deposition amyloid-β, tau hyperphosphorylation, neuroinflammation, well mitochondrial, metal ions, autophagy, cholinergic dysfunctions are known pathologic features AD. Since no definitive treatment has been proposed to target date, many natural products have shown promising preventive potentials contributed slowing down progression. Algae a source novel bioactive substances prevent disorders including In this context, fucoxanthin astaxanthin, carotenoids abundant in algae, possess neuroprotective properties through antioxidant, anti-inflammatory characteristics modulating symptoms Fucoxanthin astaxanthin exhibit anti-AD activities by inhibition AChE, BuChE, BACE-1, MAO, suppression Aβ accumulation. Also, inhibit apoptosis induced Aβ1-42 H2O2-induced cytotoxicity, modulate antioxidant enzymes (SOD CAT), ERK pathway. Moreover, cellular animal studies on beneficial effects against were also reviewed. potential role exhibits great efficacy for management acting multiple targets.

Язык: Английский

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Targeting the central nervous system: From synthetic nanoparticles to extracellular vesicles—Focus on Alzheimer's and Parkinson's disease

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2023, Номер 15(5)

Опубликована: Май 8, 2023

Abstract Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's (PD) are an accelerating global health problem life expectancy rises worldwide. Despite their significant burden in public systems to date, the existing treatments only manage symptoms without slowing down progression. Thus, ongoing neurodegenerative process remains untreated. Moreover, stronghold of brain—the blood–brain barrier (BBB)—prevents drug penetrance dwindles effective treatments. In last years, nanotechnology‐based delivery (DDS) have become a promising approach target treat these disorders related central nervous system (CNS). PLGA based nanoparticles (NPs) were first employed DDS for delivery. However, poor loading capacity localized immunogenicity prompted scientific community move another lipid‐based NPs. lipid NPs' safety effectiveness, off‐target accumulation together with denominated CARPA (complement activation‐related pseudo allergy) reaction has limited complete clinical translation. Recently, biological NPs naturally secreted by cells, termed extracellular vesicles (EVs) emerged more complex biocompatible DDS. addition, EVs act dual players NDs treatment, “cell free” therapy themselves, well new numerous characteristics that qualify them carriers over synthetic The present review aims display advantages, drawbacks, current limitations future prospective previously cited enter brain one 21st century most challenging diseases, NDs. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Neurological Disease

Язык: Английский

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