Toxicology in Vitro, Год журнала: 2024, Номер 98, С. 105814 - 105814
Опубликована: Апрель 4, 2024
Язык: Английский
Nanoscale, Год журнала: 2024, Номер 16(16), С. 7786 - 7824
Опубликована: Янв. 1, 2024
The therapeutic efficacy of nanozymes, which have wide applications in cancer treatment, can be enhanced by various biomimetic design strategies, from structural and process mimicry to advanced functional biomimicry.
Язык: Английский
Процитировано
11
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 751 - 777
Опубликована: Июль 4, 2024
Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.
Язык: Английский
Процитировано
10
Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 315 - 315
Опубликована: Фев. 28, 2024
Cancer continues to pose one of the most critical challenges in global healthcare. Despite wide array existing cancer drugs, primary obstacle remains selectively targeting and eliminating cells while minimizing damage healthy ones, thereby reducing treatment side effects. The revolutionary approach utilizing nanomaterials for delivering therapeutic agents has significantly enhanced efficacy safety chemotherapeutic drugs. This crucial shift is attributed unique properties nanomaterials, enabling nanocarriers transport tumor sites both passive active modes, drug elimination from delivery systems. Furthermore, these can be designed respond internal or external stimuli, thus facilitating controlled release. However, production nanomedications therapy encounters various that impede progress this field. review aims provide a comprehensive overview current state nanomedication treatment. It explores variety focusing on their are overcoming limitations conventional chemotherapy. Additionally, delves into functionalities nanocarriers, highlighting significant impact evolution nanomedicine. also critically assesses recent advancements systems, covering range innovative methodologies. Finally, succinctly addresses encountered developing nanomedications, offering insightful perspectives guide future research
Язык: Английский
Процитировано
9
ACS Omega, Год журнала: 2024, Номер 9(14), С. 16676 - 16686
Опубликована: Апрель 1, 2024
Oxaliplatin (Oxa) is a commonly used chemotherapy drug in the treatment of gastric cancer, but its toxic side effects and resistance after long-term use have seriously limited efficacy. Loading drugs with nanomaterials delivering them to tumor site are common ways overcome above problems. However, as carriers do not therapeutic functions on their own, effect single relatively limited, so there still room for progress related research. Herein, we construct Oxa@Mil-100(Fe) nanocomposites by loading Oxa metal–organic framework (MOF) Mil-100(Fe) high biocompatibility large specific surface area. The pore structure conducive amount drug-loading rate up 27.2%. responsive microenvironment (TME) can release Fe3+ under external stimulation. On one hand, inhibit synthesis DNA induce apoptosis cancer cells. other clear overexpressed glutathione (GSH) TME be reduced Fe2+, inhibiting activity peroxidase 4 (GPX4), leading accumulation intracellular lipid peroxides (LPO), at same time releasing number reactive oxygen species (ROS) through Fenton reaction, inducing ferroptosis With combination ferroptosis, shows good effect, killing cells obvious. In nude mouse model subcutaneous transplantation, significant inhibitory growth, an inhibition nearly 60%. addition excellent antitumor activity, has no obvious or effects. This study provides new idea method combined cancer.
Язык: Английский
Процитировано
9
Toxicology in Vitro, Год журнала: 2024, Номер 98, С. 105814 - 105814
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
8