bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 3, 2023
Abstract
Gleditsia
sinensis
Lam.
(GSL)
is
a
medicinal
herb
and
noticeable
resource
of
possessing
hepatic
protective
agents
such
as
alcoholic
liver
disease
(ALD).
At
present,
it
has
been
documented
that
gut
microbiota
(GM)
related
directly
to
etiology
ALD.
Nevertheless,
the
bioactive
molecules
in
GSL,
favorable
GM,
targets,
key
mechanism(s)
against
ALD
are
yet
be
revealed.
Hence,
we
integrated
significant
four
components
clarify
nuanced
pathogenesis
with
help
network
pharmacology
(NP)
concept.
We
retrieved
metabolites
via
gutMGene
constructed
GSL
or
GM-Signaling
pathways-Targets-Metabolites
(GGSTM)
networks.
Finally,
molecular
docking
test
(MDT)
was
performed
verify
findings.
The
suggested
16
GM
6
were
two
signaling
pathways
through
GGSTM
Both
MDT
frontier
orbitals
(FMO)
theory
revealed
most
stable
conformers:
equol
from
Lactobacillus
paracasei
JS1
on
IL6,
Bauer-7-en-3-one,
Urs-12-en-3-one
PPARA,
PPARD,
PPARG,
respectively.
In
conclusion,
this
study
sheds
light
combinatorial
effects
treating
systems
biology
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 25, 2025
Alcohol-related
liver
disease
(ALD)
is
a
chronic
injury
caused
by
long-term
excessive
alcohol
consumption,
with
complex
and
multifaceted
pathological
mechanisms.
Research
indicates
that
oxidative
stress
(OS),
inflammatory
responses,
lipid
metabolic
disturbances
induced
its
metabolites
are
primary
contributors
to
hepatocyte
injury,
positioning
OS
as
key
target
in
ALD
treatment.
The
main
non-pharmacological
treatment
for
abstinence,
while
medical
primarily
relies
on
Western
pharmacological
interventions.
However,
recent
research
has
increasingly
highlighted
the
potential
of
Chinese
botanical
drugs
improving
histological
features
modulating
signaling
pathways
associated
ALD,
underscoring
therapeutic
traditional
herb
medicine.
Despite
these
promising
findings,
precise
mechanisms
effects
extracts
remain
incompletely
understood,
side
must
be
considered.
Therefore,
comprehensive
analysis
herbal
essential
optimize
clinical
administration
ensure
safe,
effective
This
review
focuses
central
theme,
categorizing
into
six
major
groups-flavonoids,
polyphenols,
terpenoids,
alkaloids,
saponins,
anthraquinones-all
widely
used
provides
an
overview
their
characteristics
actions
context
offering
insights
regulation
exploring
treatments
ALD.
Notably,
physical
exercise
shares
overlapping
regulating
OS.
Combining
two
strategies
could
offer
integrative
though
further
needed
confirm
synergistic
benefits
applications.
Crystal Growth & Design,
Год журнала:
2024,
Номер
24(11), С. 4416 - 4427
Опубликована: Май 25, 2024
Drug
cocrystals
can
modulate
the
physical
and
chemical
properties
of
drugs,
even
complement
each
other's
strengths,
have
a
synergistic
enhancement
effect.
Here,
we
reported
drug
cocrystal
prepared
by
norfloxacin
(NOR)
naringenin
(NAR),
comprising
an
antibacterial
antitumor
active
pharmaceutical
ingredient.
The
hydrate
obtained
crystal
transformation
methods
enhanced
activity
NOR
against
one
Gram-positive
bacterium
(Staphylococcus
aureus),
three
Gram-negative
bacteria
(Escherichia
coli,
Dysentery
bacillus,
Pseudomonas
aeruginosa),
fungus
(Candida
albicans),
improved
solubility
NAR,
reduced
hygroscopicity
NOR,
anticancer
NAR
human
breast
cancer
cells
MDA-MB-231.
This
combination
has
potential
therapeutic
synergy
in
clinical
terms.
Journal of Biomedical Science,
Год журнала:
2024,
Номер
31(1)
Опубликована: Май 24, 2024
Alcohol-related
liver
disease
(ALD)
is
a
major
health
concern
worldwide,
but
effective
therapeutics
for
ALD
are
still
lacking.
Tumor
necrosis
factor-inducible
gene
6
protein
(TSG-6),
cytokine
released
from
mesenchymal
stem
cells,
was
shown
to
reduce
fibrosis
and
promote
successful
repair
in
mice
with
chronically
damaged
livers.
However,
the
effect
of
TSG-6
mechanism
underlying
its
activity
remain
poorly
understood.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 28, 2024
Alcohol-related
liver
disease
(ALD)
is
a
major
cause
of
morbidity
and
mortality
worldwide.
It
encompasses
conditions
such
as
fatty
liver,
alcoholic
hepatitis,
chronic
hepatitis
with
fibrosis
or
cirrhosis,
hepatocellular
carcinoma.
Numerous
recent
studies
have
demonstrated
the
critical
role
oxidative
stress,
abnormal
lipid
metabolism,
endoplasmic
reticulum
various
forms
cell
death
(including
apoptosis,
necroptosis,
ferroptosis),
intestinal
microbiota
dysbiosis,
immune
response,
autophagy,
epigenetic
abnormalities
in
pathogenesis
ALD.
Currently,
abstinence,
corticosteroids,
nutritional
therapy
are
traditional
therapeutic
interventions
for
Emerging
therapies
ALD
mainly
include
blockade
inflammatory
pathways,
promotion
regeneration,
restoration
normal
microbiota.
Summarizing
advances
animal
models
will
facilitate
more
systematic
investigation
exploration
targets.
This
review
summarizes
latest
insight
into
molecular
mechanisms
ALD,
well
pros
cons
rodent
models,
providing
basis
further
research
on
strategies
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 86 - 86
Опубликована: Дек. 26, 2024
Alcohol-associated
liver
disease
(ALD)
is
a
common
non-communicable
chronic
characterized
by
spectrum
of
conditions
ranging
from
steatosis
and
alcohol-associated
steatohepatitis
(AH)
to
fibrosis,
cirrhosis,
hepatocellular
carcinoma
(HCC).
The
pathogenesis
ALD
involves
complex
interplay
various
molecular,
biochemical,
genetic,
epigenetic,
environmental
factors.
While
the
mechanisms
are
well
studied,
therapeutic
options
remain
limited.
Alpinetin,
natural
flavonoid
with
antioxidant
anti-inflammatory
properties,
has
shown
potential
hepatoprotective
effects,
though
its
efficacy
in
remains
unexplored.
This
study
investigated
effects
alpinetin
using
Lieber–DeCarli
ethanol
liquid
diet
model
C57BL/6
mice.
Mice
were
divided
into
three
groups:
control
group,
group
treated
alpinetin.
Serum
activity
ALT,
AST,
γ-GT,
ALP
was
measured
assess
function,
along
antioxidative
oxidative/nitrosative
stress
markers
tissue.
Pro-inflammatory
cytokines
endoplasmic
reticulum
(ER)
parameters
tissue
also
evaluated.
Histological
assessment
performed
SALVE
grading
staging
system.
Treatment
significantly
reduced
serum
levels
while
increasing
markers.
pro-inflammatory
ER
decreased.
analysis
demonstrated
steatosis,
hepatocyte
ballooning,
inflammation.
These
findings
suggest
that
holds
promise
as
agent
for
managing
ALD.
Seminars in Liver Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Alcohol-associated
liver
disease
(ALD),
primarily
caused
by
chronic
excessive
alcohol
consumption,
is
a
leading
cause
of
worldwide.
ALD
includes
alcohol-associated
steatotic
liver,
hepatitis
(AH),
fibrosis,
cirrhosis,
and
can
even
progress
to
hepatocellular
carcinoma
(HCC).
Existing
research
indicates
that
the
risk
factors
are
quite
numerous.
In
addition
drinking
patterns,
such
as
aldehyde
dehydrogenase
2
(ALDH2)
deficiency,
smoking,
medication
administration,
high-fat
diet
(HFD),
virus
infection,
disruption
circadian
rhythms
also
increase
susceptibility
ALD.
However,
there
limited
understanding
regarding
exacerbation
injury
plus
additional
factors.
This
review
presents
rodent
models
EtOH
+
"X,"
which
simulate
synergistic
effects
in
causing
injury.
These
offer
further
exploration
interactions
between
factors,
advancing
simulation
human
providing
more
reliable
platform
for
studying
mechanisms
exploring
therapeutic
interventions.
We
summarize
modeling
methods,
relevant
indicators
injury,
focus
on
targets
well
associated
mechanisms.
