An ensemble ofGleditsia sinensis Lam. and gut microbiota against alcoholic liver disease DOI Creative Commons
Ki‐Kwang Oh,

Sang-Jun Yoon,

Su-Been Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 3, 2023

Abstract Gleditsia sinensis Lam. (GSL) is a medicinal herb and noticeable resource of possessing hepatic protective agents such as alcoholic liver disease (ALD). At present, it has been documented that gut microbiota (GM) related directly to etiology ALD. Nevertheless, the bioactive molecules in GSL, favorable GM, targets, key mechanism(s) against ALD are yet be revealed. Hence, we integrated significant four components clarify nuanced pathogenesis with help network pharmacology (NP) concept. We retrieved metabolites via gutMGene constructed GSL or GM-Signaling pathways-Targets-Metabolites (GGSTM) networks. Finally, molecular docking test (MDT) was performed verify findings. The suggested 16 GM 6 were two signaling pathways through GGSTM Both MDT frontier orbitals (FMO) theory revealed most stable conformers: equol from Lactobacillus paracasei JS1 on IL6, Bauer-7-en-3-one, Urs-12-en-3-one PPARA, PPARD, PPARG, respectively. In conclusion, this study sheds light combinatorial effects treating systems biology

Language: Английский

Solanum nigrum L. berries extract ameliorated the alcoholic liver injury by regulating gut microbiota, lipid metabolism, inflammation, and oxidative stress DOI

Xueying Wang,

Ziqi Sun,

Xiaoli Wang

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 188, P. 114489 - 114489

Published: May 9, 2024

Language: Английский

Citations

11
Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate–Activated Protein Kinase/Sirtuin 1 Pathway in Alcohol-Related Liver Disease DOI Creative Commons
Lin Zhu, Jiejie Xu, Hai-Di Li

et al.

Laboratory Investigation, Journal Year: 2023, Volume and Issue: 103(4), P. 100041 - 100041

Published: Jan. 10, 2023

Language: Английский

Citations

12
Fucoidan JHCF4s from Hizikia fusiformis against ethanol-induced damage in vitro and in vivo DOI

Tongchuan Wu,

Yichao Liu, Xingbin Ai

et al.

Food Science and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0
Establishment of an efficacy-oriented quality grading framework for herbal medicines: Phyllanthus emblica as an example DOI

Jiameng Qu,

Xuege Xu,

Junjie Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119632 - 119632

Published: March 1, 2025

Language: Английский

Citations

0
Oxidative stress modulation in alcohol-related liver disease: From chinese botanical drugs to exercise-based interventions DOI Creative Commons
Yuting Zhu,

Yuqing Jia,

Enming Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Alcohol-related liver disease (ALD) is a chronic injury caused by long-term excessive alcohol consumption, with complex and multifaceted pathological mechanisms. Research indicates that oxidative stress (OS), inflammatory responses, lipid metabolic disturbances induced its metabolites are primary contributors to hepatocyte injury, positioning OS as key target in ALD treatment. The main non-pharmacological treatment for abstinence, while medical primarily relies on Western pharmacological interventions. However, recent research has increasingly highlighted the potential of Chinese botanical drugs improving histological features modulating signaling pathways associated ALD, underscoring therapeutic traditional herb medicine. Despite these promising findings, precise mechanisms effects extracts remain incompletely understood, side must be considered. Therefore, comprehensive analysis herbal essential optimize clinical administration ensure safe, effective This review focuses central theme, categorizing into six major groups—flavonoids, polyphenols, terpenoids, alkaloids, saponins, anthraquinones—all widely used provides an overview their characteristics actions context offering insights regulation exploring treatments ALD. Notably, physical exercise shares overlapping regulating OS. Combining two strategies could offer integrative though further needed confirm synergistic benefits applications.

Language: Английский

Citations

0
Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease DOI Creative Commons
Jinsol Han, Chanbin Lee, Hayeong Jeong

et al.

Journal of Biomedical Science, Journal Year: 2024, Volume and Issue: 31(1)

Published: May 24, 2024

Alcohol-related liver disease (ALD) is a major health concern worldwide, but effective therapeutics for ALD are still lacking. Tumor necrosis factor-inducible gene 6 protein (TSG-6), cytokine released from mesenchymal stem cells, was shown to reduce fibrosis and promote successful repair in mice with chronically damaged livers. However, the effect of TSG-6 mechanism underlying its activity remain poorly understood.

Language: Английский

Citations

2
Experimental In Vivo Toxicity Models for Alcohol Toxicity DOI
Fatma Betül Yoladı,

Edanur Burmaoğlu,

Şaziye Sezin Palabıyık

et al.

Eurasian Journal of Medicine, Journal Year: 2024, Volume and Issue: 55(S1), P. 82 - 90

Published: Feb. 28, 2024

Alcohol consumption poses a significant risk for the development of chronic illnesses, one leading causes "preventable" disease and death worldwide. Harmful alcohol is thought to result in approximately 2.5-3 million deaths each year, majority which are caused by alcohol-related liver diseases. Hepatocellular carcinoma, cirrhosis, fibrosis, steatosis, steatohepatitis among illnesses alcohol. The mechanisms behind human diseases often mimicked understood through use animal models. Rodents ideal animals study In these experimental models using rodents, ethanol ratio, method administration, diet be applied vary. Within scope this review, it aimed at providing information about used today toxicity advantages disadvantages

Language: Английский

Citations

0
Cocrystal of Naringenin and Norfloxacin: Crystal Transformation, Solubility, and Antibacterial and Anticancer Activities DOI

Xin Zeng,

Chupei Zheng,

Shouliang Qiu

et al.

Crystal Growth & Design, Journal Year: 2024, Volume and Issue: 24(11), P. 4416 - 4427

Published: May 25, 2024

Drug cocrystals can modulate the physical and chemical properties of drugs, even complement each other's strengths, have a synergistic enhancement effect. Here, we reported drug cocrystal prepared by norfloxacin (NOR) naringenin (NAR), comprising an antibacterial antitumor active pharmaceutical ingredient. The hydrate obtained crystal transformation methods enhanced activity NOR against one Gram-positive bacterium (Staphylococcus aureus), three Gram-negative bacteria (Escherichia coli, Dysentery bacillus, Pseudomonas aeruginosa), fungus (Candida albicans), improved solubility NAR, reduced hygroscopicity NOR, anticancer NAR human breast cancer cells MDA-MB-231. This combination has potential therapeutic synergy in clinical terms.

Language: Английский

Citations

0
Recent advances of rodent models for alcoholic liver disease in evaluating healthy effects of food bioactive ingredients DOI Creative Commons
Xiaoting Yu, Xuedi Zhang,

Lijuan Zhang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

The development of rodent models that accurately reflect the pathogenesis alcoholic liver disease (ALD) in humans is crucial for evaluating nutritional intervention food bioactive ingredients ALD. Although various have been employed to establish ALD over past few decades, most successful cases are associated with high mortality rates, operational difficulties, and incompatibility formation mechanism compared human However, established by oral administration simulate drinking behavior often fail induce significant damage. Therefore, it imperative explore simple effective modes establishing consistent pathophysiological process Herein, we summarized discussed several issues related construct rodents (mainly mice rats) administration, including animal selection, feeding, alcohol intervention, evaluation criteria. purpose this review provide a standardized efficient formula modeling, so as facilitate efficacy analysis

Language: Английский

Citations

0
Historical and Chemical Examination of Alcohol DOI
Cem Uysal

Published: Aug. 27, 2024

Patients with idiopathic pulmonary fibrosis contemplating pregnancy should receive comprehensive pre-pregnancy counseling, including discussions about the potential risks of on disease progression and maternal health. Collaborative care involving obstetricians, pulmonologists, maternal-fetal medicine specialists is essential to optimize fetal outcomes while minimizing both. Careful consideration be given medication selection dosing during pregnancy, a focus exposure teratogenic or harmful agents maintaining stability symptom control. Close monitoring lung function, symptoms, complications necessary throughout gestation, regular assessments detect any signs exacerbations. Elderly patients fibrosis. may present age-related changes in comorbidities, functional status, necessitating individualized management approaches. Comprehensive geriatric assessment, evaluation cognitive nutritional frailty, valuable identifying addressing vulnerabilities optimizing for elderly fibrosis.nTreatment decisions balance benefits pharmacological interventions, taking into account pharmacokinetic pharmacodynamic changes, polypharmacy, frailty.

Language: Английский

Citations

0