Role of histone deacetylases and their inhibitors in neurological diseases

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107410 - 107410

Опубликована: Сен. 1, 2024

Histone deacetylases (HDACs) are zinc-dependent that remove acetyl groups from lysine residues of histones or form protein complexes with other proteins for transcriptional repression, changing chromatin structure tightness, and inhibiting gene expression. Recent in vivo vitro studies have amply demonstrated the critical role HDACs cell biology nervous system during both physiological pathological processes provided new insights into conduct research on neurological disease targets. In addition, HDAC inhibitors show promise treatment various diseases. This review summarizes regulatory mechanisms important its downstream targets diseases, therapeutic efficacy Additionally, current pharmacological situation, problems, developmental prospects described. A better understanding pathogenic may reveal interventions diseases help to relieve healthcare pressure through preventive measures.

Язык: Английский

---

Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy

Seminars in Cancer Biology, Год журнала: 2024, Номер 101, С. 58 - 73

Опубликована: Май 27, 2024

Cancer is daunting pathology with remarkable breadth and scope, spanning genetics, epigenetics, proteomics, metalobomics cell biology. Cellular senescence represents a stress-induced essentially irreversible fate associated aging various age-related diseases, including malignancies. Senescent cells are characterized of morphologic alterations metabolic reprogramming, develop highly active secretome termed as the senescence-associated secretory phenotype (SASP). Since first discovery, has been understood an important barrier to tumor progression, its induction in pre-neoplastic limits carcinogenesis. Paradoxically, senescent arising microenvironment (TME) contribute augmented therapeutic resistance. In this article, we define typical forms commonly observed within TME how functionally remodel their surrounding niche, affect immune responses promote cancer evolution. Furthermore, highlight recently emerging pipelines senotherapies particularly senolytics, which can selectively deplete from affected organs vivo impede progression by restoring securing anticancer efficacies. Together, co-targeting normal but counterparts holds potential achieve increased benefits restrained disease relapse future clinical oncology.

Язык: Английский

---

Targeting epigenetic dysregulation in autism spectrum disorders

Trends in Molecular Medicine, Год журнала: 2024, Номер 30(11), С. 1028 - 1046

Опубликована: Июль 5, 2024

Язык: Английский

---

Identification of a histone deacetylase inhibitor as a therapeutic candidate for congenital central hypoventilation syndrome

Molecular Therapy — Nucleic Acids, Год журнала: 2024, Номер 35(4), С. 102319 - 102319

Опубликована: Сен. 3, 2024

Congenital central hypoventilation syndrome (CCHS), a rare genetic disease caused by heterozygous

Язык: Английский

---

Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation

Biochemical Pharmacology, Год журнала: 2024, Номер 227, С. 116449 - 116449

Опубликована: Июль 23, 2024

Язык: Английский

---