Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 4, 2025
With
the
consistent
occurrence
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection,
prevalence
various
ocular
complications
has
increased
over
time.
SARS-CoV-2
infection
been
shown
to
have
neurotropism
and
therefore
lead
not
only
peripheral
inflammatory
responses
but
also
neuroinflammation.
Because
receptor
for
SARS-CoV-2,
angiotensin-converting
enzyme
(ACE2),
can
be
found
in
many
intraocular
tissues,
disease
2019
(COVID-19)
may
contribute
persistent
neuroinflammation,
microcirculation
dysfunction
symptoms.
Increased
awareness
neuroinflammation
future
research
on
interventional
strategies
are
important
improving
long-term
outcomes,
reducing
burden,
quality
life.
Therefore,
aim
this
review
is
focus
discuss
current
evidence
perspectives,
especially
possible
connections
between
conditions
potential
treatment
strategies.
Язык: Английский
Multi-target drugs for the treatment of cognitive impairment and fatigue in post-COVID syndrome: focus on Ginkgo biloba and Rhodiola rosea
Journal of Neural Transmission,
Год журнала:
2024,
Номер
131(3), С. 203 - 212
Опубликована: Фев. 12, 2024
Abstract
Cognitive
impairment,
depression
and
(mental)
fatigue
represent
the
most
frequent
neuropsychiatric
symptoms
of
post-COVID
syndrome.
Neuroinflammation,
oxidative
stress
mitochondrial
dysfunction
have
been
identified
as
common
pathophysiological
mechanisms
underlying
these
symptoms.
Attempts
to
treat
post-COVID-associated
cognitive
impairment
with
different
drugs
available
for
other
diseases
not
yet
successful.
One
probable
explanation
could
be
that
work
by
one
specific
mechanism
action
only
in
a
broad
multi-target
way.
Therefore,
they
will
address
spectrum
possibly
responsible
Notably,
nearly
all
currently
under
investigation
syndrome
are
rather
addressing
single
target
instead
several
pathomechanisms
this
condition.
Contrary
approach,
herbal
often
consist
many
ingredients
pharmacological
properties
targets.
might
promising
approach
treatment
symptomatic
presentation
following
SARS-CoV-2
infection.
Of
drugs,
extracts
Ginkgo
biloba
Rhodiola
rosea
probably
best
investigated
candidates.
Their
vitro
vivo
includes
anti-oxidative,
anti-inflammatory,
antidepressant
well
reducing
fatigue.
In
studies,
both
showed
positive
effects
on
physical
mental
impaired
cognition.
Moreover,
depressive
were
also
reduced
some
studies.
However,
even
if
results
promising,
data
still
preliminary
require
additional
proof
further
Язык: Английский
Management of cognitive impairment associated with post-COVID-19 syndrome: recommendations for primary care
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 22, 2024
Introduction:
Although
post-COVID-19
syndrome
(PCS)
with
cognitive
impairment
is
increasingly
encountered
in
primary
care,
evidence-based
recommendations
for
its
appropriate
management
are
lacking.
Methods:
A
systematic
literature
search
evaluating
the
diagnosis
and
treatment
of
associated
PCS
was
conducted.
Practical
PCS-associated
care
summarized,
based
on
an
evaluation
pharmacological
plausibility
clinical
applications.
Results:
Currently,
pathology
remains
unclear
no
high-quality
data
to
support
targeted
interventions.
Existing
approaches
directed
towards
symptom
relief
where
counseling
chronicity
disease
regular
reassessments
at
4-
8-week
intervals
considered
reasonable.
Patients
should
be
informed
encouraged
adopt
a
healthy
lifestyle
that
centers
around
balanced
nutrition
physical
activities.
They
may
also
benefit
from
intake
vitamins,
micronutrients,
probiotics.
The
administration
Ginkgo
biloba
extract
could
offer
safe
potentially
beneficial
option.
Other
non-pharmacological
measures
include
physiotherapy,
digitally
supported
training,
and,
if
indicated,
ergotherapy
or
speech
therapy.
In
most
patients,
symptoms
improve
within
8
weeks.
If
serious,
ambiguous,
when
new
occur,
specialized
diagnostic
such
as
comprehensive
neurocognitive
testing
neuroimaging
initiated.
Very
few
patients
would
require
inpatient
rehabilitation.
Conclusion:
debilitating
condition
affect
daily
functioning
reduce
work
productivity.
Management
multidisciplinary
approach,
centering
physical,
cognitive,
therapies.
Язык: Английский
The synergistic role of viral infection and immune response in the pathogenesis of facial palsy
Journal of NeuroVirology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 15, 2025
Abstract
Facial
palsy
refers
to
facial
muscle
paralysis
and
is
typically
brought
about
by
viral
infections,
such
as
herpes
simplex
virus
type
1
(HSV-1),
zoster
(VZV),
SARS-CoV-2.
While
significant
progress
has
been
achieved
in
pathogenesis,
mechanisms
of
infection-immunity
synergy
are
yet
be
revealed.
The
authors
this
article
made
an
attempt
fill
gap
critically
summarizing
how
infection
causes
inflammation
damage
the
nerve
through
immune
response
mechanism
pathogenesis.
We
also
summarize
current
treatment
modalities
their
respective
efficacies.
set
conditions
under
which
infections
caused
HSV-1,
VZV,
SARS-CoV-2,
HIV,
EBV
lead
viruses
infect
nerve,
initiate
response,
cause
death.
impact
involved
direct
invasion
neurons,
evasion
induction
neuroinflammation.
review
discusses
primary
role
T
cells,
B
cells
innate
inducing
or
relieving
condition.
study
emphasizes
need
understand
synergic
effect
immuneresponse
foundation
creation
more
potent
therapeutic
strategies.
paper
provides
a
detailed
overview
complex
interaction
with
level
importance
regarding
future
research
clinical
application.
Язык: Английский
Long-term Neurological Consequences of COVID-19 in Patients With Pre-existing Alzheimer’s and Parkinson’s Disease: A Comprehensive Review
Neuroscience Insights,
Год журнала:
2025,
Номер
20
Опубликована: Май 1, 2025
SARS-CoV-2,
the
causative
agent
of
COVID-19,
has
profound
systemic
effects,
including
significant
impacts
on
central
nervous
system
(CNS).
Emerging
evidence
suggests
a
potential
link
between
SARS-CoV-2-induced
neuroinflammation
and
exacerbation
or
initiation
neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
This
review
explores
mechanisms
by
which
SARS-CoV-2
may
contribute
to
processes.
We
first
discuss
pathways
viral
entry
into
CNS,
transneuronal
hematogenous
routes,
leading
blood-brain
barrier
(BBB)
dysfunction.
Neuroinflammation,
mediated
activation
microglia
astrocytes
release
pro-inflammatory
cytokines
IL-6,
TNF-α,
IL-1β,
is
highlighted
critical
factor
exacerbating
neuronal
damage.
Oxidative
stress
vascular
damage
are
further
examined
complementary
promoting
neurodegeneration.
In
addition,
we
how
infection
influences
proteinopathies
accelerating
aggregation
pathological
proteins
like
alpha-synuclein,
tau,
TDP-43,
contributing
progression
in
PD,
AD,
related
disorders.
Clinical
studies
reporting
cognitive
motor
dysfunctions
post-COVID-19
patients
with
pre-existing
also
summarized.
Finally,
this
identifies
knowledge
gaps
emphasizes
need
for
research
clarify
long-term
neurological
consequences
infection.
Understanding
these
developing
targeted
therapeutic
strategies
mitigate
risk
neurodegeneration
vulnerable
populations.
Язык: Английский
Brain FADE syndrome: the final common pathway of chronic inflammation in neurological disease
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 18, 2024
Importance
While
the
understanding
of
inflammation
in
pathogenesis
many
neurological
diseases
is
now
accepted,
this
special
commentary
addresses
need
to
study
chronic
propagation
cognitive
Fog,
Asthenia,
and
Depression
Related
Inflammation
which
we
name
Brain
FADE
syndrome.
Patients
with
syndrome
fall
void
between
neurology
psychiatry
because
depression,
fatigue,
fog
seen
these
patients
are
not
idiopathic,
but
instead
due
organic,
involved
disease
initiation.
Observations
A
review
randomized
clinical
trials
stroke,
multiple
sclerosis,
Parkinson’s
disease,
COVID,
traumatic
brain
injury,
Alzheimer’s
reveal
a
paucity
studies
any
component
as
primary
endpoint.
Furthermore,
despite
relatively
well-accepted
notion
that
critical
driving
factor
pathologies,
none
have
connected
or
over
half
suffering
from
them.
Conclusions
relevance
Syndrome
important
prevalent
examined.
Classical
“psychiatric
medications”
insufficient
address
novel
approach
utilizes
sequential
targeting
innate
adaptive
immune
responses
should
be
studied.
Язык: Английский
Fast and Sensitive Detection of Anti-SARS-CoV-2 IgG Using SiO2@Au@CDs Nanoparticle-Based Lateral Flow Immunoassay Strip Coupled with Miniaturized Fluorimeter
Rui Wang,
Junping Xue,
Wei Guo
и другие.
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1568 - 1568
Опубликована: Дек. 9, 2024
The
development
of
a
novel
strategy
for
the
measurement
SARS-CoV-2
IgG
antibodies
is
vital
significance
COVID-19
diagnosis
and
effect
vaccination
evaluation.
In
this
investigation,
an
SiO2@Au@CDs
nanoparticle
(NP)-based
lateral
flow
immunoassay
(LFIA)
strip
was
fabricated
coupled
with
miniaturized
fluorimeter.
morphology
features
particle
sizes
NPs
were
characterized
carefully,
results
indicated
that
materials
possess
monodisperse,
uniform,
spherical
structures.
Finally,
system
employed
antibody
test.
work,
test
possesses
several
merits,
such
as
speed
(less
than
15
min),
high
sensitivity
(1.2
×
10−7
mg/mL),
broad
linearity
range
(7.4
10−7~7.4
10−4
accurate
results,
selectivity,
good
stability,
low
cost.
Additionally,
future
trends
in
LFAs
using
quantum
dot-based
diagnostics
are
envisioned.
Язык: Английский