The Kidney in Obesity: Current Evidence, Perspectives and Controversies
Current Obesity Reports,
Год журнала:
2024,
Номер
13(4), С. 680 - 702
Опубликована: Авг. 14, 2024
Язык: Английский
Myokines and Their Potential Protective Role Against Oxidative Stress in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1363 - 1363
Опубликована: Ноя. 7, 2024
Myokines,
bioactive
peptides
released
by
skeletal
muscle,
have
emerged
as
crucial
regulators
of
metabolic
and
protective
pathways
in
peripheral
tissues,
particularly
combating
oxidative
stress
inflammation.
Their
plasma
concentration
significantly
increases
following
exercise,
offering
valuable
insights
into
the
role
physical
activity
preventing
sarcopenia
mitigating
diseases,
including
obesity,
diabetes,
dysfunction-associated
steatotic
liver
disease
(MASLD).
This
review
focuses
on
discussing
roles
specific
myokines
activating
intracellular
signaling
within
liver,
which
confer
protection
against
steatosis
lipid
peroxidation.
We
detail
mechanism
underlying
peroxidation
highlight
liver's
antioxidant
defenses,
such
glutathione
(GSH)
peroxidase
4
(GPX4),
are
pivotal
reducing
ferroptosis.
Furthermore,
we
provide
an
in-depth
analysis
key
myokines,
myostatin,
brain-derived
neurotrophic
factor
(BDNF),
irisin,
among
others,
their
potential
impact
function.
Finally,
discuss
molecular
mechanisms
through
these
influence
oxidate
metabolism,
emphasizing
capacity
to
modulate
responses
liver.
underscore
therapeutic
exercise
a
non-pharmacological
intervention
enhance
myokine
release,
thereby
progression
MASD
improved
hepatic
defenses.
represents
comprehensive
perspective
intersection
biology,
health.
Язык: Английский
25-hydroxyvitamin D and parathyroid hormone in new onset sepsis: A prospective study in critically ill patients
Metabolism Open,
Год журнала:
2024,
Номер
23, С. 100296 - 100296
Опубликована: Июнь 15, 2024
Hypovitaminosis
D
is
highly
prevalent
in
critically
ill
patients,
and
it
has
been
suggested
to
be
a
risk
factor
for
infections,
sepsis
higher
mortality.
We
sought
investigate
whether
serum
25-hydroxyvitamin
(25(OH)D)
parathyroid
hormone
(PTH)
patients
with
new
onset
are
associated
severity
outcome.
prospectively
included
50
consecutive
adult
cases
healthy
controls
matched
age
sex.
PTH
25(OH)D
were
determined
via
electrochemiluminescence
immunoassays
at
inclusion
the
study
all
controls,
one
week
after
cases.
Patients
had
reduced
compared
(7.9
±
3
vs
24.6
6.7
ng/mL,
p
<
0.001),
whilst
was
similar
(median
(range):
34.5
(5.7-218.5)
44.2
(14.2-98.1)
pg/mL,
=
0.35).
In
upon
enrollment
did
not
differ
significantly
7
4.3
0.19).
All
presented
hypovitaminosis
(25(OH)D
20
ng/mL),
while
40
(80
%)
vitamin
deficiency
12
ng/mL)
onset,
including
ten
(20
nonsurvivors,
who
died
within
28
days
from
onset.
(N
28)
septic
shock
22)
as
well
survivors
40)
nonsurvivors
10)
(p
>
0.05).
positively
correlated
ionized
calcium
(r
0.46,
0.001)
negatively
0.05),
inflammatory
biomarkers
or
scores
exhibited
no
correlation
25(OH)D.
lower
than
respectively
(42.2
42.9
73.4
61.9
0.04,
18.3
10.7
69.9
58.8
0.001,
respectively).
C-reactive
protein
-0.44,
0.001).
conclusion,
present
80
%
of
survivors.
Additional,
larger
multicenter
studies
warranted
elucidate
contribution
pathogenesis
its
outcomes.
Язык: Английский
Kinetics of the Lactate to Albumin Ratio in New Onset Sepsis: Prognostic Implications
Diagnostics,
Год журнала:
2024,
Номер
14(17), С. 1988 - 1988
Опубликована: Сен. 8, 2024
The
lactate
to
albumin
ratio
(LAR)
has
been
associated
with
the
severity
and
outcome
of
critical
illness
sepsis.
However,
there
are
no
studies
on
kinetics
LAR
during
early
phase
Therefore,
we
aimed
investigate
its
in
critically
ill
patients
new
onset
sepsis
regarding
We
prospectively
enrolled
102
or
septic
shock
within
48
h
from
diagnosis.
LARs
were
recorded
at
inclusion
study
one
week
later.
Patients
followed
for
28
days.
was
significantly
lower
after
enrollment
compared
baseline
all
(p
<
0.001).
higher
nonsurvivors
survivors,
respectively,
both
0.001,
p
0.001)
later
positively
(APACHE
II:
r
=
0.29,
0.003;
SOFA:
0.33,
inflammatory
biomarkers,
such
as
C-reactive
protein
(r
0.1),
procalcitonin
0.47,
0.001),
interleukin
6
0.28,
0.005)
10
0.3,
0.002)
suPAR
0.004).
In
addition,
a
LAR,
but
not
kinetics,
an
independent
predictor
28-day
mortality
(at
inclusion:
HR
2.27,
95%
C.I.
1.01–5.09,
0.04;
later:
HR:
4.29,
1.71–10.78,
0.002).
conclusion,
may
be
valuable
prognostic
indicator
admission
Язык: Английский
Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0315219 - e0315219
Опубликована: Дек. 9, 2024
Septic
shock
is
a
life-threatening
condition
characterized
by
failure
of
organ
systems
and
high
mortality
rate.
Cuproptosis
new
form
cell
death
that
triggered
copper
overload.
However,
the
relationship
between
cuproptosis-related
genes
septic
remains
unclear.
The
GSE26440
dataset
from
GEO
database
was
used
to
screen
differentially
expressed
(DEGs)
control
samples.
Additionally,
hub
related
progression
cuproptosis
were
screened
Venn
analysis.
RT-qPCR
utilized
validate
expression
in
peripheral
blood
lymphocytes
patients
healthy
controls.
Next,
functional
analysis
immune
cells
infiltration
performed.
SLC31A1
MTF1
levels
obviously
elevated
LIAS
LIPT1
downregulated
samples,
compared
normal
diagnostic
values
four
confirmed
with
receiver
operating
characteristic
(ROC)
curves.
showed
positive
correlation
natural
killer
exhibited
CD8+
T
cells.
Furthermore,
low-level
groups,
MAPK
signaling
activated
high-SLC31A1
level
group,
VEGF
high-MTF1
group
lipoic
acid
metabolism
high-LIAS
high-LIPT1
groups.
This
study
demonstrates
SLC31A1,
MTF1,
LIAS,
are
dysregulated
these
exhibit
potential
efficacy
shock,
suggesting
may
be
biomarkers
for
diagnosis
shock.
Язык: Английский