Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies DOI Creative Commons

Yunuo Yang,

Jiaxuan Wu, Wenjun Zhou

и другие.

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 30, 2024

Abstract Metabolism‐related diseases, including diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease, are becoming increasingly prevalent, thereby posing significant threats to human health longevity. Proteins, as the primary mediators of biological activities, undergo various posttranslational modifications (PTMs), phosphorylation, ubiquitination, acetylation, methylation, SUMOylation, among others, which substantially diversify their functions. These crucial in physiological pathological processes associated with metabolic disorders. Despite advancements field, there remains a deficiency contemporary summaries addressing how these influence disease. This review aims systematically elucidate mechanisms through PTM proteins impact progression diabetes, Additionally, limitations current body research critically assessed. Leveraging PTMs provides novel insights therapeutic targets for prevention treatment Numerous drugs designed target currently preclinical or clinical trials. also comprehensive summary. By elucidating intricate interplay between pathways, this study advances understanding molecular underlying dysfunction, facilitating development more precise effective disease management strategies.

Язык: Английский

Insulin oxidation and oxidative modifications alter glucose uptake, cell metabolism, and inflammatory secretion profiles DOI Creative Commons
Ramona Clemen,

Wiebke Dethloff,

Julia Berner

и другие.

Redox Biology, Год журнала: 2024, Номер 77, С. 103372 - 103372

Опубликована: Окт. 5, 2024

Insulin participates in glucose homeostasis the body and regulates glucose, protein, lipid metabolism. Chronic hyperglycemia triggers oxidative stress generation of reactive oxygen species (ROS), leading to oxidized insulin variants. Oxidative protein modifications can cause functional changes or altered immunogenicity as known from context autoimmune disorders. However, studies on biological function native cellular are lacking. Native showed heterogenous effects metabolic activity, proliferation, carrier transporter (GLUT) 4, receptor (INSR) expression, well uptake cell lines five different human tissues. Diverse ROS compositions produced by gas plasma approaches enabled investigations variously modified (oxIns) with individual post-translational modification (oxPTM) patterns identified using high-resolution mass spectrometric analysis. Specific oxIns variants promoted metabolism proliferation several investigated, nitrogen emission could be linked nitration elevated uptake. In addition, oxidation blood levels chicken embryos (in ovo), underlining importance assessing health disease.

Язык: Английский

Процитировано

4
Bio-Pathological Functions of Posttranslational Modifications of Histological Biomarkers in Breast Cancer DOI Creative Commons

Anca-Narcisa Neagu,

Claudiu-Laurentiu Josan,

Taniya Jayaweera

и другие.

Molecules, Год журнала: 2024, Номер 29(17), С. 4156 - 4156

Опубликована: Сен. 2, 2024

Proteins are the most common types of biomarkers used in breast cancer (BC) theranostics and management. By definition, a biomarker must be relevant, objective, stable, quantifiable biomolecule or other parameter, but proteins known to exhibit variate profound structural functional variation. Thus, proteome is highly dynamic permanently reshaped readapted, according changing microenvironments, maintain local cell tissue homeostasis. It that protein posttranslational modifications (PTMs) can affect all aspects function. In this review, we focused our analysis on different PTMs histological BC. analyzed PTMs, including phosphorylation, acetylation, methylation, ubiquitination, SUMOylation, neddylation, palmitoylation, myristoylation, glycosylation/sialylation/fucosylation transcription factors, proliferation marker Ki-67, plasma membrane proteins, histone modifications. Most these occur presence cellular stress. We emphasized interfere with maintenance, turnover lifespan, nuclear subcellular localization, structure function, stabilization inactivation, initiation silencing genomic non-genomic pathways, transcriptional activities signaling mitosis, proteostasis, cell–cell cell–extracellular matrix (ECM) interactions, trafficking, PPIs. Moreover, orchestrate hallmark pathways dysregulated BC, playing both pro- and/or antitumoral context-specific roles DNA damage, repair stability, inactivation/activation tumor-suppressor genes oncogenes, phenotypic plasticity, epigenetic regulation gene expression non-mutational reprogramming, proliferative signaling, endocytosis, death, TME, invasion metastasis, epithelial–mesenchymal/mesenchymal–epithelial transition (EMT/MET), resistance therapy reversal multidrug resistance. nucleus also at cytoplasmic level induce translocation opposite effects. Analysis allows for discovery validation new mainly early diagnosis, like extracellular vesicle glycosylation, which may considered as potential source circulating biomarkers.

Язык: Английский

Процитировано

2
Role of MicroRNA in linking diabetic retinal neurodegeneration and vascular degeneration DOI Creative Commons
Haiyan Zhao, Yichen Cai, Junhua Pan

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июль 4, 2024

Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular are two primary pathological processes retinopathy. The retinal nervous system cells have a close coupling relationship. connection between neurodegeneration yet fully understood. Recent studies found microRNA plays role regulating neurovascular can help delay progression disease. This article will review how acts as bridge connecting degeneration, focusing on mechanisms apoptosis, oxidative stress, inflammation, endothelial factors. aim to identify valuable targets for new research clinical

Язык: Английский

Процитировано

1
Application of Ti4+ embedded functional composite materials in simultaneous enrichment of glycopeptides and phosphopeptides DOI

WenGeng Ti,

Meiyan Liu,

AnYu Xie

и другие.

Talanta, Год журнала: 2024, Номер 282, С. 126955 - 126955

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

0
Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies DOI Creative Commons

Yunuo Yang,

Jiaxuan Wu, Wenjun Zhou

и другие.

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 30, 2024

Abstract Metabolism‐related diseases, including diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease, are becoming increasingly prevalent, thereby posing significant threats to human health longevity. Proteins, as the primary mediators of biological activities, undergo various posttranslational modifications (PTMs), phosphorylation, ubiquitination, acetylation, methylation, SUMOylation, among others, which substantially diversify their functions. These crucial in physiological pathological processes associated with metabolic disorders. Despite advancements field, there remains a deficiency contemporary summaries addressing how these influence disease. This review aims systematically elucidate mechanisms through PTM proteins impact progression diabetes, Additionally, limitations current body research critically assessed. Leveraging PTMs provides novel insights therapeutic targets for prevention treatment Numerous drugs designed target currently preclinical or clinical trials. also comprehensive summary. By elucidating intricate interplay between pathways, this study advances understanding molecular underlying dysfunction, facilitating development more precise effective disease management strategies.

Язык: Английский

Процитировано

0