The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production DOI Creative Commons
Yang Li, Yujia Zhang, Xinyu He

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 711 - 711

Published: Dec. 18, 2024

Mitochondrial metabolism plays a pivotal role in regulating the synthesis of secondary metabolites, which are crucial for survival and adaptation organisms. These metabolites synthesized during specific growth stages or response to environmental stress, reflecting organism’s ability adapt changing conditions. Mitochondria, while primarily known their energy production, directly regulate metabolite biosynthesis by providing essential precursor molecules, energy, reducing equivalents necessary metabolic reactions. Furthermore, they indirectly influence through intricate signaling pathways, including reactive oxygen species (ROS), redox signaling, modulate various processes. This review explores recent advances understanding molecular mechanisms governing mitochondrial regulatory roles biosynthesis, highlights involvement transcription factors, small RNAs, post-translational modifications shaping these By integrating current insights, it aims inspire future research into Arabidopsis thaliana, Solanum tuberosum, Nicotiana tabacum, others that may enhance production. A deeper mitochondria could contribute development new approaches biotechnology applications.

Language: Английский

Sterol biosynthesis disruption by common prescription medications: critical implications for neural development and brain health DOI Open Access
Željka Korade, Károly Mirnics

Brain medicine :, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: Feb. 25, 2025

Sterol biosynthesis is essential for cellular function, producing not only cholesterol but also critical bioactive molecules that regulate cell signaling, growth, and membrane function. In the brain, metabolism operates independently behind blood–brain barrier, maintaining its own homeostatic balance. An emerging concern in clinical pharmacology discovery many common prescription drugs unintentionally interfere with post-lanosterol sterol synthesis pathways. While acute effects of these medications are documented, their long-term consequences brain development function remain unclear. Studies using cultures mouse models indicate heightened risk during pregnancy, where drug-induced disruption may interact genetic factors from both mother fetus, particularly when multiple prescribed. This significant research gap has important implications practice. Our review consolidates current evidence about how affect outlines areas requiring urgent investigation.

Language: Английский

Citations

1
Biochemical Markers as Predictors of Health Outcomes in Autism Spectrum Disorder: A Comprehensive Systematic Review and Meta-analysis DOI
Walaa Mohammedsaeed,

Mohammed Alharbi

Journal of Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 75(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Medication-induced sterol disruption: An overlooked threat to brain development and public health DOI
Júlio Licinio

Brain medicine :, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: April 22, 2025

Language: Английский

Citations

0
Inhibition of post-lanosterol biosynthesis by fentanyl: potential implications for Fetal Fentanyl Syndrome (FFS) DOI
Željka Korade, Allison Anderson, Kanika Sharma

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Language: Английский

Citations

3
Alterations in the proteomes of HepG2 and IHKE cells inflicted by six selected mycotoxins DOI Creative Commons
Lucas Keuter,

Marco Fortmann,

Matthias Behrens

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Abstract Toxic fungal secondary metabolites, referred to as mycotoxins, emerge in moldy food and feed constitute a potent but often underestimated health threat for humans animals. They are structurally diverse can cause diseases after dietary intake even low concentrations. To elucidate cellular responses identify targets of bottom-up proteomics approach was used. We investigated the effects mycotoxins aflatoxin B 1 , ochratoxin A, citrinin, deoxynivalenol, nivalenol penitrem A on human hepatoblastoma cell line HepG2 citrinin kidney epithelial IHKE. Incubations were carried out at sub-cytotoxic concentrations monitor molecular before acute death mechanisms predominate. Through these experiments, we able detect specific that point towards mycotoxins’ mode action. Besides very well-described like ribotoxicity trichothecenes, observed not yet described different mechanisms. For instance, trichothecenes lowered apolipoprotein abundance affected proteins related inflammation, ribogenesis mitosis. Ochratoxin upregulated minichromosomal maintenance complex nucleotide synthesis downregulated histones Penitrem reduced enzyme levels sterol biosynthesis. These results will aid elucidation toxicodynamic properties this highly relevant class toxins.

Language: Английский

Citations

2
Loss of Sterol Biosynthesis in Economically Important Plant Pests and Pathogens: A Review of a Potential Target for Pest Control DOI Creative Commons
Andréa Caroline Ruthes, Andréa Caroline Ruthes

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1435 - 1435

Published: Nov. 11, 2024

Sterol biosynthesis is a crucial metabolic pathway in plants and various plant pathogens. Their vital physiological role multicellular organisms their effects on growth reproduction underline importance as membrane compounds, hormone precursors, signaling molecules. Insects, nematodes, oomycetes of the Peronosporales group, which harbor important agricultural pests pathogens, have lost ability to synthesize own sterols. These rely acquisition sterols from host are dependent sterol composition host. It thought that sterol-synthesizing enzymes were during co-evolution with hosts, provided sufficient amounts required To meet essential requirements these organisms, some auxotrophs retained few remaining sterol-modifying enzymes. Several molecular biochemical investigations suggested promising avenues for pest pathogen control by targeting composition, uptake, or modification biosynthesize de novo. This review examines loss novo insects, aim investigating constraints organisms. will shed light its potential target management sterol-dependent comprehensive agronomic approach.

Language: Английский

Citations

1
The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production DOI Creative Commons
Yang Li, Yujia Zhang, Xinyu He

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(12), P. 711 - 711

Published: Dec. 18, 2024

Mitochondrial metabolism plays a pivotal role in regulating the synthesis of secondary metabolites, which are crucial for survival and adaptation organisms. These metabolites synthesized during specific growth stages or response to environmental stress, reflecting organism’s ability adapt changing conditions. Mitochondria, while primarily known their energy production, directly regulate metabolite biosynthesis by providing essential precursor molecules, energy, reducing equivalents necessary metabolic reactions. Furthermore, they indirectly influence through intricate signaling pathways, including reactive oxygen species (ROS), redox signaling, modulate various processes. This review explores recent advances understanding molecular mechanisms governing mitochondrial regulatory roles biosynthesis, highlights involvement transcription factors, small RNAs, post-translational modifications shaping these By integrating current insights, it aims inspire future research into Arabidopsis thaliana, Solanum tuberosum, Nicotiana tabacum, others that may enhance production. A deeper mitochondria could contribute development new approaches biotechnology applications.

Language: Английский

Citations

0