Implementation of Three Gallium-Based Complexes in the “Trojan Horse” Antibacterial Strategy against A. baumannii: A DFT Approach DOI
Nikoleta Kircheva, Stefan Dobrev, Valya Nikolova

и другие.

Inorganic Chemistry, Год журнала: 2024, Номер 63(33), С. 15409 - 15420

Опубликована: Авг. 8, 2024

Microorganisms of the ESKAPE group pose an enormous threat to human well-being, thus requiring a multidisciplinary approach for discovering novel drugs that are not only effective but utilize innovative mechanism action in order decrease fast developing resistance. A promising still hardly explored implementation "Trojan horse" antibacterial strategy has been recognized gallium, iron mimicry species with no known function exerting bacteriostatic/bactericidal effect against some representatives group. The study herewith focuses on bacterium A. baumannii and its siderophore acinetobactin two isomeric forms depending acidity medium. By applying powerful tools DFT approach, we aim delineate those physicochemical characteristics great importance potentiating gallium's ability compete native ferric cation binding such as pH, solvent exposure (dielectric constant environment), different metal/siderophore ratios, complex composition. Hence, provided results furnish explanation positive three Ga3+-based anti-infectives terms metal competition also shed light reported vitro vivo observations at molecular level regard baumannii.

Язык: Английский

γ-polyglutamic acid-encapsulated metformin-loaded Ga-Car-MOF and hydrocaffeic acid-modified chitosan double-layer microneedle patch for accelerated bacterial-infected wound healing DOI

Xueting Liu,

Yajing Zhu,

Yutong Jing

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140959 - 140959

Опубликована: Фев. 12, 2025

Язык: Английский

Процитировано

0
Influence of morphology and surface properties on the antibacterial action of GaOOH microparticles DOI
Dustin Johnson,

P.K. Ahluwalia,

James H. Brannon

и другие.

Biointerphases, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

The growing threat of antibiotic-resistant bacteria necessitates the development alternative antimicrobial agents. Gallium oxyhydroxide (GaOOH) is a promising candidate, though its direct antibacterial efficacy unexplored. This study provides first evidence GaOOH microparticles exhibiting cytotoxic effects against both Gram-positive Staphylococcus aureus (S.aureus) and Gram-negative Escherichia coli (E. coli). Orthorhombic particles were synthesized hydrothermally, with their morphology influenced by pH synthesis process, as confirmed scanning electron microscopy x-ray diffraction analysis. Antibacterial assays revealed that cytotoxicity E. increases higher pH, trend we demonstrate to be associated enhanced defect density in particles, supported photoluminescence spectra FTIR underscores significant influence conditions on crystallinity resulting microparticles, highlighting surface characteristics

Язык: Английский

Процитировано

0
Implementation of Three Gallium-Based Complexes in the “Trojan Horse” Antibacterial Strategy against A. baumannii: A DFT Approach DOI
Nikoleta Kircheva, Stefan Dobrev, Valya Nikolova

и другие.

Inorganic Chemistry, Год журнала: 2024, Номер 63(33), С. 15409 - 15420

Опубликована: Авг. 8, 2024

Microorganisms of the ESKAPE group pose an enormous threat to human well-being, thus requiring a multidisciplinary approach for discovering novel drugs that are not only effective but utilize innovative mechanism action in order decrease fast developing resistance. A promising still hardly explored implementation "Trojan horse" antibacterial strategy has been recognized gallium, iron mimicry species with no known function exerting bacteriostatic/bactericidal effect against some representatives group. The study herewith focuses on bacterium A. baumannii and its siderophore acinetobactin two isomeric forms depending acidity medium. By applying powerful tools DFT approach, we aim delineate those physicochemical characteristics great importance potentiating gallium's ability compete native ferric cation binding such as pH, solvent exposure (dielectric constant environment), different metal/siderophore ratios, complex composition. Hence, provided results furnish explanation positive three Ga3+-based anti-infectives terms metal competition also shed light reported vitro vivo observations at molecular level regard baumannii.

Язык: Английский

Процитировано

2