Molecules,
Год журнала:
2024,
Номер
29(17), С. 4270 - 4270
Опубликована: Сен. 9, 2024
This
study
proposes
an
affordable
plasma
device
that
utilizes
a
parallel-plate
dielectric
barrier
discharge
geometry
with
metallic
mesh
electrode,
featuring
straightforward
3D-printed
design.
Powered
by
high-voltage
supply
adapted
from
cosmetic
device,
it
operates
on
atmospheric
air,
eliminating
the
need
for
gas
flux.
Surface
modification
of
polyethylene
treated
this
was
characterized
and
showed
elemental
composition
after
15
min
treatment
decreased
amount
C
to
~80
at%
due
insertion
O
(~15
at%).
Tested
against
Biomolecules,
Год журнала:
2024,
Номер
14(4), С. 503 - 503
Опубликована: Апрель 21, 2024
Cancer
remains
one
of
the
global
leading
causes
death
and
various
vaccines
have
been
developed
over
years
against
it,
including
cell-based,
nucleic
acid-based,
viral-based
cancer
vaccines.
Although
many
effective
in
vivo
clinical
studies
some
FDA-approved,
there
are
major
limitations
to
overcome:
(1)
developing
universal
vaccine
for
a
specific
is
difficult,
as
tumors
with
different
antigens
individuals,
(2)
tumor
may
be
similar
body’s
own
antigens,
(3)
possibility
recurrence.
Therefore,
personalized
ability
distinguish
between
indispensable.
This
paper
provides
comprehensive
review
types
highlights
important
factors
necessary
efficient
Moreover,
application
other
technologies
therapy
discussed.
Finally,
several
insights
conclusions
presented,
such
using
cold
plasma
stem
cells
future
vaccines,
tackle
developmental
process.
Free Radical Research,
Год журнала:
2023,
Номер
57(3), С. 239 - 270
Опубликована: Март 4, 2023
This
review
provides
a
description
of
the
historical
background
development
biological
applications
low-temperature
plasmas.
The
generation
plasma,
methods
and
devices,
plasma
sources,
measurements
properties,
such
as
electron
dynamics
chemical
species
in
both
gaseous
aqueous
phases,
were
assessed.
Currently,
direct
irradiation
for
discharges
contacting
surfaces,
skin
teeth,
are
related
to
interactions.
Indirect
using
plasma-treated
liquids
based
on
plasma-liquid
use
these
two
is
rapidly
increasing
preclinical
studies
cancer
therapy.
authors
address
prospects
further
developments
therapeutic
by
understanding
interactions
between
living
organisms.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 26, 2025
Chronic
and
acute
wounds
represent
significant
challenges
in
healthcare,
often
leading
to
prolonged
recovery
times
increased
complications.
While
chronic
wounds,
such
as
diabetic
foot
ulcers
venous
leg
ulcers,
persist
due
underlying
conditions
biofilm
formation,
including
surgical
incisions
burns,
can
also
benefit
from
innovative
therapeutic
approaches.
Cold
atmospheric
plasma
(CAP)
has
emerged
a
promising
non-invasive
therapy
capable
of
enhancing
wound
healing
outcomes
across
both
types.
This
review
examines
the
cellular
molecular
mechanisms
by
which
CAP
promotes
repair,
focusing
on
its
modulation
inflammation,
stimulation
angiogenesis,
facilitation
tissue
remodeling,
antimicrobial
effects,
potentially
be
used
regenerative
medicine.
generates
reactive
oxygen
nitrogen
species
that
influence
key
processes,
accelerating
regeneration
while
reducing
bacterial
load
preventing
formation.
Clinical
applications
have
demonstrated
efficacy
improving
metrics
for
wounds.
Despite
results,
translating
into
routine
clinical
practice
requires
addressing
standardizing
treatment
protocols,
assessing
long-term
safety,
developing
portable
devices.
Future
research
should
prioritize
optimizing
parameters
exploring
combination
therapies
maximize
potential.
Overall,
represents
safe,
effective,
versatile
modality
management,
with
potential
significantly
improve
patient
care.
Animals,
Год журнала:
2025,
Номер
15(7), С. 968 - 968
Опубликована: Март 27, 2025
Cold
atmospheric
plasma
(CAP)
is
emerging
as
an
innovative
approach
for
cancer
treatment
because
of
its
selectivity
malignant
cells
and
absence
significant
adverse
effects.
While
modern
oncological
therapies
face
challenges
such
tumor
heterogeneity
resistance,
CAP
presents
itself
a
low-cost
environmentally
sustainable
alternative.
Its
mechanisms
action
involve
reactive
oxygen
nitrogen
species
(RONS),
UV
radiation,
electromagnetic
fields,
which
induce
cell
death.
Preclinical
clinical
studies
have
demonstrated
the
efficacy
CAP,
with
devices
dielectric
barrier
discharge
(DBD)
jet
developed
to
minimize
damage
healthy
cells.
Some
are
already
approved
use,
showing
safety
efficacy.
However,
standardization
treatments
remains
challenge
due
variety
parameters
used.
Although
has
shown
promising
cytotoxic
effects
in
vitro
animal
models,
especially
different
lines,
further
research,
particularly
vivo
veterinary
medicine,
needed
optimize
use
maximize
combating
cancer.
Biomolecules,
Год журнала:
2023,
Номер
13(9), С. 1371 - 1371
Опубликована: Сен. 11, 2023
Plasma
medicine,
or
the
biomedical
application
of
cold
atmospheric
plasma
(CAP),
is
an
expanding
field
within
research.
CAP
has
demonstrated
remarkable
versatility
in
diverse
biological
applications,
including
cancer
treatment,
wound
healing,
microorganism
inactivation,
and
skin
disease
therapy.
However,
precise
mechanisms
underlying
effects
remain
incompletely
understood.
The
therapeutic
are
largely
attributed
to
generation
reactive
oxygen
nitrogen
species
(RONS),
which
play
a
crucial
role
responses
induced
by
CAP.
Specifically,
RONS
produced
during
treatment
have
ability
chemically
modify
cell
membranes
membrane
proteins,
causing
nitro-oxidative
stress,
thereby
leading
changes
permeability
disruption
cellular
processes.
To
gain
atomic-level
insights
into
these
interactions,
non-reactive
molecular
dynamics
(MD)
simulations
emerged
as
valuable
tool.
These
facilitate
examination
larger-scale
system
dynamics,
protein-protein
protein-membrane
interactions.
In
this
comprehensive
review,
we
focus
on
applications
MD
studying
components
interactions
at
atomic
level,
providing
detailed
overview
potential
medicine.
We
also
review
results
other
studies
that
not
related
medicine
but
explore
stress
therefore
important
for
broader
understanding
ACS Omega,
Год журнала:
2025,
Номер
10(12), С. 12109 - 12121
Опубликована: Март 6, 2025
Transitional
cold
atmospheric
plasma
(TCAP)
represents
a
novel
technique
for
generating
remotely
from
primary
source.
It
consists
of
partially
nonthermal
ionized
gas
mixture
containing
charged
and
neutral
particles,
photons,
free
radicals.
In
recent
years,
TCAP
has
attracted
considerable
attention
in
biomedical
applications.
order
to
evaluate
colon
cancer
stem
cells'
(CCSCs)
proliferation,
apoptotic
induction,
inflammatory
response,
survival,
was
utilized
both
directly
indirectly
this
study.
Using
argon
helium
gases,
continuously
delivered
two
stages
during
the
experiment.
For
direct
state,
irradiated
onto
CCSCs
3
5
min.
indirect
technique,
Matrigel
treated
with
min
before
introduction
cells.
vitro
assays
demonstrated
that
exposure
significantly
reduced
viability
CCSCs;
application
had
greater
impacts
than
argon.
Numerous
investigations
confirmed
induction
apoptosis,
showing
groups
more
cells
altered
cellular
structures
controls
(****p
<
0.0001).
A
substantial
increase
Bax/Bcl-2
ratio
found
by
analyzing
expression
Bax
Bcl-2
genes,
indicating
increased
susceptibility
apoptosis
(*p
=
0.0177
***p
0.0004).
The
higher
efficacy
mode
further
highlighted
marker
analysis,
which
showed
significant
reduction
interleukin-6
interleukin-8
TCAP-helium
compared
TCAP-argon
(**p
0.0015
0.0007).
Lastly,
proliferation
test,
relies
on
Ki-67
expression,
noteworthy
decline
all
TCAP-treated
groups,
group
exhibiting
most
robust
impact
0.0014).
Overall,
findings
highlight
potential
TCAP,
particularly
helium,
as
promising
approach
selectively
targeting
providing
insights
into
its
therapeutic
mechanisms
treatment.
therefore,
emerges
unique
strategy
applications
cell-targeted
therapies.
