Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 28, 2023
Introduction
The
mesial
temporal
lobe
plays
a
distinct
role
in
epileptogenesis,
and
tumors
this
part
of
the
brain
potentially
have
specific
clinical
radiological
features.
Differentiating
high-grade
from
lower-grade
or
non-neoplastic
lesions
can
be
challenging,
preventing
decision
for
early
resection
that
critical
tumors.
Methods
A
tumor
database
was
analyzed
retrospectively
to
identify
patients
with
temporomesial
We
determined
features
(age,
sex,
symptoms
leading
presentation)
as
well
neuroradiological
(tumor
location
presence
contrast
enhancement
on
initial
magnetic
resonance
imaging
(MRI))
neuropathological
findings.
Results
identified
324
39
involved
lobe.
77%
occured
males,
presented
seizures,
regardless
type
grade.
In
50
years
older,
90%
were
male
80%
had
glioblastoma
(GBM);
there
no
GBM
younger
than
years.
50%
GBMs
lacked
enhancement.
Male
sex
significantly
associated
GBM.
both
contrast-enhancing
non-enhancing
tumors,
age
older
also
Conclusion
middle-aged
tumor,
is
most
likely
diagnosis
even
when
MRI
Prolonged
diagnostic
workup
surveillance
strategies
should
avoided
may
justified
these
patients.
Brain Sciences,
Год журнала:
2024,
Номер
14(3), С. 296 - 296
Опубликована: Март 20, 2024
In
this
paper,
we
discuss
how
the
clustering
analysis
technique
can
be
applied
to
analyze
functional
magnetic
resonance
imaging
(fMRI)
time-series
data
in
context
of
glioblastoma
(GBM),
a
highly
heterogeneous
brain
tumor.
The
precise
characterization
GBM
is
challenging
and
requires
advanced
analytical
approaches.
We
have
synthesized
existing
literature
provide
an
overview
algorithms
help
identify
unique
patterns
within
dynamics
GBM.
Our
review
shows
that
fMRI
time
series
has
great
potential
for
improving
differentiation
between
various
subtypes
GBM,
which
pivotal
developing
personalized
therapeutic
strategies.
Moreover,
method
proves
effective
capturing
temporal
changes
occurring
enhancing
monitoring
disease
progression
response
treatment.
By
thoroughly
examining
consolidating
current
research,
paper
contributes
understanding
techniques
refine
This
article
emphasizes
importance
incorporating
cutting-edge
into
neuroimaging
neuro-oncology
research.
providing
detailed
perspective,
approach
may
guide
future
investigations
boost
development
tailored
strategies
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 375 - 375
Опубликована: Фев. 6, 2024
Research
on
the
development
of
photodynamic
therapy
for
treatment
brain
tumors
has
shown
promise
in
this
highly
aggressive
form
cancer.
Analysis
both
vivo
studies
and
clinical
shows
that
can
provide
significant
benefits,
such
as
an
improved
median
rate
survival.
The
use
is
characterized
by
relatively
few
side
effects,
which
a
advantage
compared
to
conventional
methods
often-used
tumor
surgery,
advanced
radiotherapy,
classic
chemotherapy.
Continued
research
area
could
bring
advances,
influencing
future
standards
difficult
deadly
disease.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 10, 2024
Glioblastoma
(GBM)
is
a
highly
malignant,
invasive,
and
poorly
prognosed
brain
tumor.
Unfortunately,
active
comprehensive
treatment
does
not
significantly
prolong
patient
survival.
With
the
deepening
of
research,
it
has
been
found
that
gut
microbiota
plays
certain
role
in
GBM,
can
directly
or
indirectly
affect
efficacy
immune
checkpoint
inhibitors
(ICIs)
various
ways.
(1)
The
metabolites
produced
by
host’s
homeostasis,
these
function
distribution
cells,
promote
inhibit
inflammatory
responses,
phenotype,
angiogenesis,
response,
cell
infiltration
GBM
thereby
affecting
effectiveness
ICIs.
(2)
Some
members
may
reverse
T
inhibition,
increase
anti-tumor
activity,
ultimately
improve
ICIs
targeting
specific
immunosuppressive
cytokines.
(3)
participate
metabolic
process
drugs,
which
degrade,
transform,
produce
metabolites,
effective
concentration
bioavailability
drugs.
Optimizing
structure
help
(4)
also
regulate
status
through
axis
communication,
progression
therapeutic
response
to
(5)
Given
importance
for
ICI
therapy,
researchers
have
begun
exploring
use
fecal
transplantation
(FMT)
transplant
healthy
optimized
patients,
order
their
enhance
therapy.
Preliminary
studies
suggest
FMT
therapy
some
patients.
In
summary,
crucial
regulating
with
deeper
understanding
relationship
between
tumor
immunity,
expected
develop
more
precise
personalized
strategies
prognosis.
Neuroglia,
Год журнала:
2025,
Номер
6(1), С. 3 - 3
Опубликована: Янв. 4, 2025
Background/Objectives:
Glioblastoma
(GBM),
a
highly
aggressive
grade
IV
astrocytoma,
poses
major
therapeutic
challenge
due
to
the
resistance
of
cancer
stem
cells
(CSCs)
existing
within
its
cell
population
conventional
therapies.
Recently,
we
reported
that
RNA
interference
targeting
CSC
protection
mechanism
significantly
improved
efficacy.
However,
challenges
remain,
including
limited
transfection
efficiency
in
neural
and
difficulty
crossing
blood–brain
barrier
(BBB).
Methods:
In
this
study,
investigated
potential
exosome-mediated
delivery
cargo
GBM
by
engineering
exosomes
carry
green
fluorescent
protein
(GFP)
expressing
brain-homing
peptide
(BHP)
on
their
surface,
which
has
high
affinity
cells.
Results:
We
found
BHP-modified
doubled
GFP
efficacy
from
20%
40%,
outperforming
traditional
methods
like
lipofection
vitro.
vivo,
demonstrated
an
ability
cross
BBB
targeted
brain
regions
following
intranasal
subcutaneous
administration.
Conclusions:
These
results
underscore
engineered
for
efficient
enhance
against
tumors
suggest
novel
avenues
delivering
biomolecules
treatment
neurological
disorders.
Cancers,
Год журнала:
2023,
Номер
15(18), С. 4429 - 4429
Опубликована: Сен. 5, 2023
Glioma
and
glioblastoma
multiform
(GBM)
remain
among
the
most
debilitating
life-threatening
brain
tumors.
Despite
advances
in
diagnosing
approaches,
patient
follow-up
after
treatment
(surgery
chemoradiation)
is
still
challenging
for
differentiation
between
tumor
progression/recurrence,
pseudoprogression,
radionecrosis.
Radiomics
emerges
as
a
promising
tool
initial
diagnosis,
grading,
survival
prediction
patients
with
glioma
can
help
differentiate
these
post-treatment
scenarios.
Preliminary
published
studies
are
about
role
of
radiomics
glioma/GBM.
However,
this
field
faces
significant
challenges,
including
lack
evidence-based
solid
data,
scattering
publication,
heterogeneity
studies,
small
sample
sizes.
The
present
review
explores
radiomics's
capabilities
following
glioma/GBM
status
to
progression,
recurrence,
Future Pharmacology,
Год журнала:
2025,
Номер
5(1), С. 7 - 7
Опубликована: Фев. 1, 2025
Glioblastoma
(GBM)
is
the
most
aggressive
brain
tumor,
characterized
by
high
recurrence
rates
and
poor
patient
outcomes.
Treatment
failure
driven
multiple
factors,
including
complex
tumor
heterogeneity,
presence
of
cancer
stem
cells,
immunosuppressive
microenvironment
(TME),
many
others.
GBM’s
heterogeneity
underlines
its
ability
to
resist
therapies
adapt
TME.
The
TME,
which
highly
shaped
hypoxia,
impairs
anti-tumor
immunity
limits
efficacy
immunotherapy.
blood–brain
barrier
(BBB)
remains
a
major
obstacle
delivering
sufficient
drug
concentrations
restricting
penetration
therapeutic
agents.
Another
problem
lack
reliable
biomarkers
perform
better
stratification
or
even
guide
personalized
treatments,
resulting
in
generalized
approaches
that
do
not
adequately
address
GBM
complexities.
This
review
highlights
multifactorial
nature
treatment
need
for
paradigm
shift
innovative,
strategies.
A
deeper
understanding
biology
advances
translational
research
will
be
crucial
developing
effective
improving
outcomes
this
devastating
disease.
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Glioblastoma,
an
aggressive
and
lethal
brain
tumor,
presents
enormous
clinical
challenges,
including
molecular
heterogeneity,
high
recurrence
rates,
resistance
to
conventional
therapies,
limited
therapeutic
penetration
across
the
blood-brain
barrier.
The
glioblastoma
microenvironment,
characterized
by
a
dynamic
interplay
of
cellular
non-cellular
components,
is
key
driver
tumor
growth
resistance.
Neuroinflammatory
cytokines,
particularly
interleukins
necrosis
factor-alpha,
play
pivotal
roles
in
this
contributing
progression
immune
evasion.
This
review
highlights
oncolytic
virotherapy
as
promising
avenue,
focusing
on
its
potential
modulate
neuroinflammatory
responses,
induce
localized
reactions,
deliver
immunomodulatory
factors
directly
site.
While
encouraging
outcomes
have
been
observed,
challenges
such
overcoming
barrier,
managing
host
antiviral
immunity,
mitigating
risks
normal
neuronal
cells
remain
critical
barriers
translation.
By
analyzing
intricate
interactions
viruses
with
microenvironment
synthesizing
findings
from
preclinical
trials,
provides
actionable
insights
into
developing
personalized
effective
strategies
for
based
alone
or
when
using
it
combined
immunotherapy,
natural
killer-cell
therapy,
chimeric
antigen
receptor-T
cell
dendritic
therapy.
Cancers,
Год журнала:
2024,
Номер
16(16), С. 2870 - 2870
Опубликована: Авг. 17, 2024
Glioblastoma:
a
highly
aggressive
brain
tumor,
presents
substantial
challenges
in
treatment
and
management,
with
surgical
intervention
playing
pivotal
role
improving
patient
outcomes.
Disparities
access
to
tumor
surgery
arise
from
multitude
of
factors,
including
socioeconomic
status,
geographical
location,
healthcare
resource
allocation.
Low-
middle-income
countries
(LMICs)
often
face
significant
barriers
accessing
services,
such
as
shortages
specialized
neurosurgical
expertise,
limited
infrastructure,
financial
constraints.
Consequently,
glioblastoma
patients
LMICs
experience
delays
diagnosis,
suboptimal
treatment,
poorer
clinical
outcomes
compared
high-income
(HICs).
The
impact
these
disparities
is
profound.
Patients
are
more
likely
be
diagnosed
at
advanced
disease
stages,
receive
less
effective
have
lower
survival
rates
than
their
counterparts
HICs.
Additionally,
care
exacerbate
economic
societal
burdens,
emphasizing
the
urgent
need
for
targeted
interventions
health
policy
reforms
address
inequities.
This
review
highlights
importance
addressing
global
through
collaborative
efforts,
advocacy,
allocation,
aiming
improve
promote
equity
delivery
all
worldwide.
