LINC00513 promotes colorectal cancer malignant progression by binding with IGF2BP1 to enhance the stability of connective tissue growth factor mRNA DOI
Weijian Lun,

Xiaobin Zhang,

Yinsheng Hong

и другие.

Epigenomics, Год журнала: 2024, Номер 16(14), С. 985 - 998

Опубликована: Июль 17, 2024

Aim: This study aimed to investigate the role of LINC00513 in colorectal cancer (CRC) progression. Materials & methods: Cell proliferation was evaluated using Counting Kit-8. migration detected with transwell assay. RNA pull-down applied for verifying interactions between LINC00513, IGF2BP1 and connective tissue growth factor (CTGF). Results: CTGF levels were upregulated CRC. Knockdown significantly inhibited malignant behavior CRC cells. increased mRNA stability by binding IGF2BP1. Furthermore, overexpression or reversed inhibitory effect shRNA on Conclusion: promoted cell behaviors through IGF2BP1/CTGF.

Язык: Английский

LINC00513 promotes colorectal cancer malignant progression by binding with IGF2BP1 to enhance the stability of connective tissue growth factor mRNA DOI
Weijian Lun,

Xiaobin Zhang,

Yinsheng Hong

и другие.

Epigenomics, Год журнала: 2024, Номер 16(14), С. 985 - 998

Опубликована: Июль 17, 2024

Aim: This study aimed to investigate the role of LINC00513 in colorectal cancer (CRC) progression. Materials & methods: Cell proliferation was evaluated using Counting Kit-8. migration detected with transwell assay. RNA pull-down applied for verifying interactions between LINC00513, IGF2BP1 and connective tissue growth factor (CTGF). Results: CTGF levels were upregulated CRC. Knockdown significantly inhibited malignant behavior CRC cells. increased mRNA stability by binding IGF2BP1. Furthermore, overexpression or reversed inhibitory effect shRNA on Conclusion: promoted cell behaviors through IGF2BP1/CTGF.

Язык: Английский

Процитировано

1