International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13086 - 13086
Опубликована: Дек. 5, 2024
Alzheimer's
disease
imposes
an
increasing
burden
on
aging
Western
societies.
The
disorder
most
frequently
appears
in
its
sporadic
form,
which
can
be
caused
by
environmental
and
polygenic
factors
or
monogenic
conditions
of
incomplete
penetrance.
According
to
the
authors,
majority
cases,
represents
aggravated
form
natural
central
nervous
system.
It
characterized
decreased
elimination
amyloid
β
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 574 - 574
Опубликована: Март 5, 2024
Neurodegeneration
poses
a
significant
challenge
for
the
fields
of
neuroscience
and
medicine,
as
it
is
underlying
cause
development
advancement
numerous
neurodegenerative
psychiatric
disorders
[...]
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 613 - 613
Опубликована: Март 8, 2024
Neuroscience,
neurology,
and
psychiatry
are
rapidly
evolving
fields
that
aim
to
understand
the
complex
mechanisms
underlying
brain
function
dysfunction,
as
well
develop
effective
interventions
for
various
neurological
psychiatric
disorders
[...]
Cells,
Год журнала:
2024,
Номер
13(10), С. 790 - 790
Опубликована: Май 7, 2024
Translational
research
in
neurological
and
psychiatric
diseases
is
a
rapidly
advancing
field
that
promises
to
redefine
our
approach
these
complex
conditions
[...]
The
editorial
explores
the
realm
of
emerging
translational
research
in
neurology
and
psychiatry,
providing
insights
into
various
subjects,
including
neurodegenerative
disorders
innovative
therapeutic
methods.
main
objective
is
to
study
neurological
psychiatric
disorders,
such
as
Alzheimer's
disease,
with
a
particular
emphasis
on
techniques
for
neural
regeneration
repair.
highlights
importance
taking
comprehensive
approach
studying
treating
complex
conditions.
This
involves
thoroughly
reviewing
papers
causes,
development,
biomarkers,
treatment
options
these
emphasizes
necessity
using
multidisciplinary
integrative
methods
gain
deeper
understanding
improve
development
an
animal
model
recurrent
primary
dysmenorrhea
showcases
employed
investigation
gynecological
illustrating
capacity
connect
fundamental
scientific
knowledge
practical
medical
applications.
cooperative
endeavors
researchers
clinicians
emphasized
this
lay
foundation
revolutionary
advancements
that
hold
potential
enhance
outcomes
individuals
afflicted
globally.
Delve
into
the
dynamic
realms
of
neuroscience,
neurology,
and
psychiatry
with
this
groundbreaking
editorial,
unveiling
intricate
mechanisms
brain
function
dysfunction.
Explore
latest
advancements
in
molecular
biology,
genetics,
epigenetics,
pharmacology,
neuroimaging
that
are
revolutionizing
our
understanding
neurological
psychiatric
disorders.
Uncover
challenges
gaps
translating
cutting-edge
research
practical
clinical
applications,
aiming
to
enhance
lives
patients
their
families.
Discover
pivotal
role
neuroplasticity
reshaping
brain's
adaptability
throughout
life,
alongside
promising
potential
non-invasive
stimulation
techniques
like
transcranial
magnetic
direct
current
stimulation.
Embark
on
a
journey
innovation
collaboration
as
researchers
clinicians
strive
bridge
gap
between
bench
bedside,
offering
hope
for
improved
diagnosis,
prevention,
treatment
complex
conditions.
Join
us
exploration
transformative
ideas
novel
interventions
hold
key
brighter
future
individuals
society.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 484 - 484
Опубликована: Янв. 8, 2025
Alzheimer's
disease
(AD)
remains
a
leading
cause
of
cognitive
decline
and
mortality
worldwide,
characterized
by
neurodegeneration,
synaptic
deficiencies,
neuroinflammation.
Despite
advancements
in
early
detection,
diagnosis,
treatment,
AD
presents
substantial
challenges
due
to
its
complex
pathology,
heterogeneity,
the
limited
efficacy
current
therapies.
Consequently,
there
is
pressing
need
for
novel
therapeutic
agents
target
multifaceted
aspects
enhance
treatments,
minimize
adverse
effects.
AdipoRon,
an
adiponectin
receptor
agonist,
has
garnered
interest
potential
neuroprotective
effects,
including
reducing
neuroinflammation,
improving
mitochondrial
function,
mitigating
tau
hyperphosphorylation.
This
review
aimed
evaluate
effects
AdipoRon-based
replacement
therapy
against
AD,
using
comprehensive
approach
grounded
PICO
framework-Population,
Intervention,
Comparison,
Outcomes.
A
total
six
studies
were
reviewed,
vitro
vivo
investigations
examining
AdipoRon's
impact
on
various
models.
These
involved
different
cell
lines
transgenic
mouse
models,
assessing
outcomes
such
as
phosphorylation,
relevant
molecular
pathways.
By
synthesizing
data
from
these
studies,
our
thoroughly
explains
mechanisms
action,
agent
AD.
analysis
aims
highlight
state
knowledge,
identify
gaps
research,
suggest
directions
future
clinical
applications.
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(1)
Опубликована: Янв. 20, 2025
Backgrounds:
Memory
and
emotion
are
especially
vulnerable
to
psychiatric
disorders
such
as
post-traumatic
stress
disorder
(PTSD),
which
is
linked
disruptions
in
serotonin
(5-HT)
metabolism.
Over
90%
of
the
5-HT
precursor
tryptophan
(Trp)
metabolized
via
Trp-kynurenine
(KYN)
metabolic
pathway,
generates
a
variety
bioactive
molecules.
Dysregulation
KYN
metabolism,
particularly
low
levels
kynurenic
acid
(KYNA),
appears
be
neuropsychiatric
disorders.
The
majority
KYNA
produced
by
aadat
(kat2)
gene-encoded
mitochondrial
kynurenine
aminotransferase
(KAT)
isotype
2.
Little
known
about
consequences
deleting
enzyme
gene.
Methods:
In
CRISPR/Cas9-induced
knockout
(kat2-/-)
mice,
we
examined
effects
on
emotion,
memory,
motor
function,
Trp
its
metabolite
levels,
activities
plasma
urine
8-week-old
males
compared
wild-type
mice.
Results:
Transgenic
mice
showed
more
depressive-like
behaviors
forced
swim
test,
but
not
tail
suspension,
anxiety,
or
memory
tests.
They
also
had
fewer
center
field
corner
entries,
shorter
walking
distances,
jumping
counts
open
test.
Plasma
generally
consistent
with
those
urine:
antioxidant
KYNs,
5-hydroxyindoleacetic
acid,
indole-3-acetic
were
lower;
KATs,
kynureninase,
monoamine
oxidase/aldehyde
dehydrogenase
lower,
3-monooxygenase
was
higher;
oxidative
excitotoxicity
indices
higher.
displayed
depression-like
behavior
learned
helplessness
model,
emotional
indifference,
deficits,
coupled
decrease
KYNA,
shift
metabolism
toward
KYN-3-hydroxykynurenine
partial
gut
microbial
Trp-indole
pathway
metabolite.
Conclusions:
This
first
evidence
that
gene
induces
uniquely
experiences
despair,
appear
associated
excitatory
neurotoxic
stresses.
may
lead
development
double-hit
preclinical
model
despair-based
depression,
better
understanding
these
complex
conditions,
effective
therapeutic
strategies
elucidating
relationship
between
PTSD
pathogenesis.
Cells,
Год журнала:
2024,
Номер
13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine
is
a
debilitating
neurological
disorder
characterized
by
recurring
episodes
of
throbbing
headaches
that
are
frequently
accompanied
sensory
disturbances,
nausea,
and
sensitivity
to
light
sound
[...]
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3394 - 3394
Опубликована: Март 16, 2024
The
central
nervous
system
(CNS)
is
the
final
frontier
in
drug
delivery
because
of
blood–brain
barrier
(BBB),
which
poses
significant
barriers
to
access
most
drugs
their
targets.
Kynurenic
acid
(KYNA),
a
tryptophan
(Trp)
metabolite,
plays
an
important
role
behavioral
functions,
and
abnormal
KYNA
levels
have
been
observed
neuropsychiatric
conditions.
current
challenge
lies
delivering
CNS
owing
its
polar
side
chain.
Recently,
C-3
chain-modified
analogs
shown
cross
BBB;
however,
it
unclear
whether
they
retain
biological
functions
parent
molecule.
This
study
examined
impact
analogs,
specifically,
SZR-72,
SZR-104,
newly
developed
SZRG-21,
on
behavior.
were
administered
intracerebroventricularly
(i.c.v.),
effects
motor
domain
compared
with
those
KYNA.
Specifically,
open-field
(OF)
rotarod
(RR)
tests
employed
assess
activity
skills.
SZR-104
increased
horizontal
exploratory
OF
test
at
dose
0.04
μmol/4
μL,
while
SZR-72
decreased
vertical
doses
0.1
μL.
In
RR
test,
neither
nor
showed
any
differences
skills
either
dose.
Side
chain
modification
affects
affective
performance
behavior,
as
results
show
for
first
time.
this
study,
we
that
alter
emotional
components
such
motor-associated
curiosity
emotions.
Consequently,
design
necessitates
development
precise
strategies
traverse
BBB
paying
close
attention
modifications
