Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 75 - 75

Опубликована: Янв. 10, 2025

Recent developments in single-cell multi-omics technologies have provided the ability to identify diverse cell types and decipher key components of tumor microenvironment (TME), leading important advancements toward a much deeper understanding how heterogeneity contributes cancer progression therapeutic resistance. These are able integrate data from molecular genomic, transcriptomic, proteomics, metabolomics studies cells at resolution scale that give rise full cellular complexity TME. Understanding complex sometimes reciprocal relationships among cells, CAFs, immune ECs has led novel insights into their immense functions, which can consequences on behavior. In-depth uncovered evasion mechanisms, including exhaustion T metabolic reprogramming response hypoxia cells. Single-cell also revealed resistance such as stromal cell-secreted factors physical barriers extracellular matrix. Future examining specific pathways targeting approaches reduce TME will likely lead better outcomes with immunotherapies, drug delivery, etc., for treatments. incorporate data, spatial micro-environments, translation personalized therapies. This review emphasizes provide TME, revealing reprogramming, influences. aim guide development targeted therapies, highlighting role diversity shaping behavior treatment outcomes.

Язык: Английский

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Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Год журнала: 2025, Номер 13(2), С. 422 - 422

Опубликована: Фев. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Язык: Английский

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Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Год журнала: 2025, Номер 15(2), С. 270 - 270

Опубликована: Фев. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Язык: Английский

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Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk

Nutrients, Год журнала: 2025, Номер 17(5), С. 776 - 776

Опубликована: Фев. 23, 2025

Dyslipidemia, characterized by abnormal blood lipid levels, is a major public health concern due to its association with atherosclerotic cardiovascular disease (ASCVD) and other cardiometabolic disorders. In this context, appropriate nutrition patterns are pivotal as they represent the basic approach for providing wide range of substantial advantages. The best evidence dyslipidemia management offered Mediterranean Diet, Plant-Based High-Fiber Diet Anti-inflammatory while DASH Ketogenic have also been shown target additional pathological features like hypertension comorbidities. bioactive compounds that enriched in these able manage include monounsaturated fatty acids such ω-3, polyphenols oleuropein, resveratrol, flavonoids, catechins, carotenoids, phytosterols soluble unsoluble fibers. Diets rich can improve profile mitigating oxidative stress, reducing low-grade chronic inflammation, modulating macronutrient absorption mechanisms, thereby supporting health. Additionally, lifestyle interventions regular physical activity, weight loss, reduced alcohol consumption smoking cessation further ameliorate metabolism circulated profile. Furthermore, emerging insights from nutrigenomics underscore potential proper diet address genetic factors optimize treatment outcomes. role context implications discussed review, emphasizing evidence-based personalized approaches.

Язык: Английский

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A review of sarcoidosis etiology, diagnosis and treatment

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 26, 2025

Sarcoidosis is an inflammatory disease characterized by the formation of granulomas in various organs, leading to inflammation and potential organ dysfunction. Symptoms often start with general signs like fatigue, fever, weight loss, but vary depending on affected organ. Diagnosis challenging due its diverse clinical presentation lack a definitive test, while treatment complicated disease's variable course, requiring personalized approach. This review explores role genetic environmental factors sarcoidosis etiology, examines current challenges diagnosis treatment, discusses how understanding etiology informs patient management future strategies.

Язык: Английский

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Advances in bioinformatic methods for the acceleration of the drug discovery from nature

Phytomedicine, Год журнала: 2025, Номер 139, С. 156518 - 156518

Опубликована: Фев. 14, 2025

Язык: Английский

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ADME gene-driven prognostic model for bladder cancer: a breakthrough in predicting survival and personalized treatment

Hereditas, Год журнала: 2025, Номер 162(1)

Опубликована: Март 19, 2025

Abstract Background Genes that participate in the absorption, distribution, metabolism, excretion (ADME) processes occupy a central role pharmacokinetics. Meanwhile, variability clinical outcomes and responses to treatment is notable bladder cancer (BLCA). Methods Our study utilized expansive datasets from TCGA GEO explore prognostic factors cancer. Utilizing both univariate Cox regression lasso techniques, we identified ADME genes critical for patient outcomes. our study, model assessing risk was constructed. The evaluation of this model's predictive precision conducted using Kaplan–Meier survival curves assessments based on ROC curves. Furthermore, devised nomogram, offering straightforward visualization crucial indicators. To potential mediating differences between high low groups, performed comprehensive analyses including Gene Ontology (GO) Kyoto Encyclopedia Genomes (KEGG)-based enrichment analyses, immune infiltration variations, somatic mutation landscapes, pharmacological sensitivity response assessment etc. Immediately following this, selected core PPI network explored as well modulation, pathway activation. And differential expression verified by immunohistochemistry qRT-PCR. Finally pan-cancer biomarkers. Results efforts culminated establishment validated 17-gene ADME-centered prediction model, displaying remarkable accuracy BLCA prognosis. Through separate cox importance model’s score forecasting substantiated. novel nomogram incorporating variables alongside introduced. Comprehensive studies established strong correlation several key indicators: patterns cell infiltration, reactions immunotherapy, landscape profiles drug sensitivity. We screened gene CYP2C8, its tumor bioregulation upregulated found it can serve reliable biomarker pan-cancer. Conclusion formulated research stands formidable instrument prognosis, while also providing insights into disease's progression mechanisms guiding decision-making strategies.

Язык: Английский

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Innovative Micro- and Nano-Architectures in Biomedical Engineering for Therapeutic and Diagnostic Applications

Micromachines, Год журнала: 2025, Номер 16(4), С. 419 - 419

Опубликована: Март 31, 2025

The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields therapeutic diagnostic micromechanics. This review explores recent innovations nanostructured materials their transformative impact on healthcare applications, ranging from drug delivery tissue engineering to biosensing diagnostics. Key advances fabrication techniques, such as lithography, 3D printing, self-assembly, have enabled unprecedented control over material properties functionalities at microscopic scales. These engineered architectures offer enhanced precision targeting controlled release delivery, foster cellular interactions improve sensitivity specificity devices. We examine critical design parameters, including biocompatibility, mechanical resilience, scalability, which influence clinical efficacy long-term stability. also highlights translational potential current limitations bringing these laboratory research practical applications. By providing a comprehensive overview trends, challenges, future perspectives, this article aims inform inspire further development that hold promise for advancing personalized medicine.

Язык: Английский

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Therapeutic potential of microbiome modulation in reproductive cancers

Medical Oncology, Год журнала: 2025, Номер 42(5)

Опубликована: Апрель 6, 2025

Язык: Английский

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Integrated Genomics and Multi-OMICS in Precision and Personalised Medicine: Emerging New Paradigm for Clinical Medicine

Apollo Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Genomics is one of core components very basic biological processes transcription, translation and peptide molecule synthesis, collectively known as the ‘central dogma life’. This basis multitude sciences with OMICS suffix, for example, transcriptomics, proteomics, metabolomics others. Almost all OMIC have direct or indirect bearing on many interrelated relevant to integrated molecular pathways systems body organs functioning tissues. The concept multi-OMICS medicine now supported by recurrent outcomes fundamental applied life research. common purpose deliver healthcare precisely possible targeted at specific points in an individual patient thus satisfying requirement personalised medicine. There growing interest evidence integrate traditional ancient like Ayurveda. review provides factual information context evidence-based, ethically sound, precision

Язык: Английский

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