Clinical and Preventive Medicine,
Год журнала:
2024,
Номер
3, С. 46 - 54
Опубликована: Май 8, 2024
The
aim
of
the
work
–
to
study
peculiarities
shape
and
surface
relief
main
types
dental
implants.
Materials
methods.
12
implants
used
in
medical
practice
Ukrainian
clinics
were
studied.
was
carried
out
using
a
scanning
electron
microscope
GSM-649
(Japan).
Results.
All
apical
part
have
cone
with
threads
cutting
grooves.
thread
large
profile
is
located
implant,
has
an
average
pitch
turns
1.1±0.05
mm
height
0.3±0.02
mm.
small
implant
near
neck,
0.4±0.02
0.1±0.02
single
0.8±0.05
mm,
0.2±0.01
Threads
triangular
angle
50.0±2.9
degrees.
highest
roughness
top
fine
micro-uniformities
from
7.0±2.2
36.0±8.3
μm,
smallest
3.0±1.1
14.0±6.1
μm
areas
area
neck.
Conclusions.
50%
examined
made
two
profiles:
one
side
closer
same
end
In
most
implants,
form
annular
had
rectangular,
rounded
or
steps.
some
as
they
approach
changes
decreases.
all
close
rounded.
different
roughness.
recorded
on
thread,
lowest
without
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(4), С. 83 - 83
Опубликована: Март 27, 2024
Dental
implants
and
bone
augmentation
are
among
dentistry's
most
prevalent
surgical
treatments;
hence,
many
dental
implant
surfaces
grafts
have
been
researched
to
improve
response.
Such
new
materials
were
radiologically,
histologically,
histomorphometrically
evaluated
on
animals
before
being
used
humans.
As
a
result,
several
studies
evaluate
novel
technologies,
biocompatibility,
techniques,
osseointegration
strategies,
as
preclinical
research
animal
models
is
essential
bioactive
principles
(on
cells,
compounds,
implants)
that
can
act
through
multiple
mechanisms
predict
behavior,
which
difficult
from
in
vitro
alone.
In
this
study,
we
critically
reviewed
all
different
investigating
the
degree
of
surfaces,
reporting
species
over
last
30
years.
Moreover,
first
study
summarize
reviews
main
translational
osseointegration,
including
advantages
limitations
each
model
determining
ideal
location
for
small
large
models.
Overall,
has
disadvantages;
selection
should
be
based
cost
acquisition,
care,
acceptability
society,
availability,
tolerance
captivity,
housing
convenience.
Among
models,
rabbits
an
biological
observations
around
implants,
it
worth
noting
was
discovered
rabbit
successfully
applied
Clinical Oral Investigations,
Год журнала:
2024,
Номер
28(11)
Опубликована: Окт. 11, 2024
Abstract
Background
Bioactive
surface
modifications
have
been
proposed
to
enhance
osseointegration
and
longevity
of
dental
implants.
This
study
aimed
systematically
review
perform
a
meta-analysis
on
the
effectiveness
various
bioactive
coatings
in
promoting
bone
integration
improving
implant
longevity.
Methods
A
systematic
was
conducted,
including
studies
that
investigated
titanium
Outcomes
interest
were
bone-to-implant
contact
(BIC)
over
30-day
period.
Data
extracted
analyzed
using
RevMan
5
(version
5.4.1),
with
forest
plots
generated
represent
mean
difference
(MD)
95%
confidence
intervals
(CI)
under
random
effects
model.
Results
The
showed
significant
improvement
BIC
for
surface-modified
implants,
an
overall
MD
7.29
(95%
CI
[2.94,
11.65]).
Heterogeneity
analysis
indicated
moderate
heterogeneity
(Tau²
=
18.57,
Chi²
16.08,
df
8,
P
0.04,
I²
50%).
test
effect
yielded
Z
3.28
(
0.001).
For
longevity,
7.52
[3.18,
11.85]),
17.28,
14.95,
0.06,
47%).
3.40
0.0007).
Conclusion
changes
significantly
improved
lifespan
Collagen-based
consistently
encouraged
early
integration,
while
BMP-2
combinations
effective
osseointegration.
Optimizing
agent
doses
critical
achieving
desired
outcomes.
International Journal of Implant Dentistry,
Год журнала:
2025,
Номер
11(1)
Опубликована: Март 12, 2025
Abstract
Purpose
This
study
assessed
the
impact
of
buccal
bone
on
hard
and
soft
tissues
in
submerged
non-submerged
immediate
implants
using
a
minipig
model.
Methods
Sixty-five
titanium
(Camlog
Progressive
Line)
were
placed
four
minipigs
immediately
after
tooth
extraction.
All
(NSM)
received
mechanically
induced
defect
(NSM-BD),
whereas
group
(SM)
was
classified
as
defective
(SM-BD)
intact
(SM-BI).
defects
underwent
guided
regeneration
(GBR).
After
months,
sacrificed.
Harvested
specimens
analysed
histomorphometry
light
fluorescence
microscopy.
The
evaluated
parameters
included
sulcus
(S),
implant
epithelium
(IE),
connective
tissue
(CT),
biological
width
(BW),
highest
point
(HSTP),
first
contact
(FHTC).
Results
Of
65
(6%)
lost,
while
all
remaining
demonstrated
clinical
stability
(Periotest).
Despite
GBR
failures
caused
by
pigs’
hay
consumption
one
week,
no
significant
differences
(
p
>
0.5)
observed
between
SM-BD
NSM-BD
(NSM-BD/SM-BD:
S
=
0.6
mm,
IE
2.9/2.4
CT
3.5/3.4
BW
5.9/5.8
mm).
Compared
to
SM-BI
soft-tissue
increased
length
with
reduced
lamella
(SM-BI/SM-BD:
0.4/0,6
mm;
≤
0.04,
SM-BI/NSM-BD:
1.8/2.9
0.007,
SM-BI/SM-BD:
2.5/3.4
0.01,
4.0/5.8
0.007).
HSTP
remained
unaffected
0.5;
(NSM-BD
1.8
1.0
2.0
for
groups.
Conclusion
A
resulted
prolonged
S,
IE,
CT,
BW.
However,
aesthetic
parameter
did
not
exhibit
at
site
when
comparing
SM
NSM
healing
protocols.
Graphical
In vitro models,
Год журнала:
2022,
Номер
1(4-5), С. 289 - 307
Опубликована: Авг. 4, 2022
Abstract
Bone
pain
typically
occurs
immediately
following
skeletal
damage
with
mechanical
distortion
or
rupture
of
nociceptive
fibres.
The
mechanism
is
also
associated
chronic
conditions
where
the
healing
process
impaired.
Any
load
impacting
on
area
fractured
bone
will
stimulate
response,
necessitating
rapid
clinical
intervention
to
relieve
and
appropriate
mitigation
any
processes
involved
loss
mass,
muscle,
mobility
prevent
death.
review
has
examined
mechanisms
trauma
cancer-related
focusing
new
approaches
for
development
innovative
therapeutic
interventions.
In
particular,
highlights
tissue
engineering
that
offer
considerable
promise
in
application
functional
biomimetic
fabrication
nerve
tissues.
strategic
combination
engineered
models
provides
significant
potential
develop
a
class
vitro
platforms,
capable
replacing
vivo
testing
safety
efficacy
novel
drug
treatments
aimed
at
resolution
bone-associated
pain.
To
date,
field
research
centred
animal
models,
paucity
data
correlating
human
physiological
response.
This
explores
evident
gap
suggests
step
change
approach
harness
technologies
recapitulate
complex
pathophysiological
environment
damaged
enabling
evaluation
pain-mimicking
therein
improved
patient
quality
life.
Graphical
abstract
Rationale
underlying
platform
development.
Pain
detected
by
central
nervous
system
fracture
cannot
be
treated
exclusively
alleviated
using
standardised
methods.
specificity/efficacy
reduction
drugs
remain
poorly
understood.
ex
are
not
yet
able
various
events
damage.
currently
limited
their
inability
fully
mimic
play
between
disruption
pathological
states.
Robust
needed
better
understand
investigate
regimes
Applied Sciences,
Год журнала:
2022,
Номер
12(3), С. 1373 - 1373
Опубликована: Янв. 27, 2022
Bone
regeneration
is
a
central
focus
of
maxillofacial
research,
especially
when
dealing
with
dental
implants
or
critical
sized
wound
sites.
While
bone
has
great
potential,
exogenous
delivery
growth
factors
can
greatly
enhance
the
speed,
duration,
and
quality
osseointegration,
making
difference
in
patient’s
life.
morphogenic
protein
2
(BMP-2)
highly
potent
factor
that
acts
as
recruiting
molecule
for
mesenchymal
stromal
cells,
induces
rapid
differentiation
them
into
osteoblasts,
while
also
maintaining
their
viability.
Currently,
literature
data
shows
liposomal
direct
transfection
plasmids
containing
BMP-2
at
site
often
results
overexpression
osteogenic
markers
result
enhanced
mineralization
formation
new
matrix.
We
reviewed
on
scientific
regarding
help
liposomes.
This
may
provide
ground
future
strategy
real
chances
reaching
clinical
practice.
Polymers,
Год журнала:
2024,
Номер
16(8), С. 1101 - 1101
Опубликована: Апрель 15, 2024
The
aim
of
this
study
was
to
evaluate
the
use
a
flexible
synthetic
polymer
bone
graft
provide
implant
stability
during
placement
in
dense
cortical
model.
In
control
group
(Group
1),
sockets
were
prepared
on
polyurethane
blocks
according
standard
socket
drilling
protocol;
both
oversizing
and
deepening
applied
Group
2;
only
3.
Groups
2
3,
grafts
placed
prior
placement.
implants
at
level
all
groups.
highest
torque
value
obtained
recorded
as
insertion
torque.
study,
75
sites
included
across
three
values
significantly
higher
than
those
with
oversized
deepened
oversized-only
(p
<
0.05;
p
0.01).
shown
be
effective
achieving
management
where
there
has
been
loss
primary
stability.
Biomimetics,
Год журнала:
2024,
Номер
9(11), С. 672 - 672
Опубликована: Ноя. 3, 2024
Bone
histology
and
histomorphometry
are
reliable
diagnostic
tools
for
the
assessment
of
bone-implant
interface,
material
safety
biocompatibility,
tissue
response.
They
allow
qualitative
quantitative
analysis
undecalcified
bone
specimens.
This
scoping
review
aims
to
identify
most
common
staining
techniques,
study
models
in
vivo
experiments,
histomorphometric
parameters
used
evaluation
osseointegrated
dental
implants
last
decade.
The
Web
Science,
PubMed,
Scopus
databases
were
searched
on
1
July
2024
relevant
articles
English,
published
ten
years,
data
exported
an
MS
Excel
spreadsheet.
A
total
115
studies
met
eligibility
criteria
included
present
review.
results
indicate
that
dogs,
rabbits,
pigs.
Some
frequently
methods
interface
Toluidine
blue,
Stevenel's
blue
with
Van
Gieson,
Levai-Laczko
stainings.
from
this
demonstrate
commonly
implant
dentistry
bone-to-implant
contact
(BIC),
area
fraction
occupancy
(BAFO),
(BA),
density
(BD).
presents
recent
trends
identifies
some
research
gaps
necessitate
further
research.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 11, 2024
Dental
implant
therapy
faces
challenges
in
patients
with
Type
1
and
2
Diabetes
Mellitus
(T1DM
T2DM)
due
to
adverse
effects
on
bone
metabolism
immune
response.
Despite
advancements,
diabetic
face
higher
risks
of
peri-implantitis
compromised
osseointegration.
This
review
assesses
the
impact
anti-diabetic
medications
outcomes,
offering
insights
bridge
gap
between
animal
studies
clinical
practice.
By
evaluating
pharmacotherapeutic
strategies
preclinical
models,
this
guides
future
research
designs
improve
success
rates
individuals.
