International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3274 - 3274
Опубликована: Март 14, 2024
Throughout
history,
natural
products
have
played
a
significant
role
in
wound
healing.
Fibroblasts,
acting
as
primary
cellular
mediators
skin
healing,
exhibit
behavioral
responses
to
compounds
that
can
enhance
the
healing
process.
Identifying
bioactive
and
understanding
their
impact
on
fibroblast
behavior
offers
crucial
translational
opportunities
realm
of
Modern
scientific
techniques
enabled
detailed
how
naturally
derived
modulate
by
influencing
behavior.
Specific
known
for
properties
been
identified.
Engineered
biomimetic
replicating
microenvironment
are
designed
facilitate
normal
Advanced
delivery
methods
operating
at
micro-
nano-scales
developed
effectively
deliver
these
novel
through
stratum
corneum.
This
review
provides
comprehensive
summary
efficacy
promoting
regeneration
repair.
Additionally,
it
explores
engineering,
where
researchers
draw
inspiration
from
nature
create
materials
devices
mimicking
physiological
cues
effective
The
concludes
describing
mechanisms
aimed
enhancing
bioavailability
compounds.
Innovative
future
strategies
involve
exploring
fibroblast-influencing
pathways,
responsive
biomaterials,
smart
dressings
with
real-time
monitoring,
applications
stem
cells.
However,
translating
findings
clinical
settings
faces
challenges
such
limited
validation
biomaterials
large
animal
models
logistical
obstacles
industrial
production.
integration
ancient
remedies
modern
approaches
holds
promise
achieving
scar-free
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101531 - 101531
Опубликована: Фев. 5, 2025
Three-dimensional
(3D)
printing
technology
has
shown
significant
promise
in
the
medical
field,
particularly
orthopedics,
prosthetics,
tissue
engineering,
and
pharmaceutical
preparations.
This
review
focuses
on
innovative
application
of
3D
addressing
challenges
osteonecrosis
femoral
head
(ONFH).
Unlike
traditional
hip
replacement
surgery,
which
is
often
suboptimal
for
younger
patients,
offers
precise
localization
necrotic
areas
ability
to
create
personalized
implants.
By
integrating
advanced
biomaterials,
this
a
promising
strategy
approach
early
hip-preserving
treatments.
Additionally,
3D-printed
bone
engineering
scaffolds
can
mimic
natural
environment,
promoting
regeneration
vascularization.
In
future,
potential
extends
combining
with
artificial
intelligence
optimizing
treatment
plans,
developing
materials
enhanced
bioactivity
compatibility,
translating
these
innovations
from
laboratory
clinical
practice.
demonstrates
how
uniquely
addresses
critical
ONFH
treatment,
including
insufficient
vascularization,
poor
mechanical
stability,
limited
long-term
success
conventional
therapies.
introducing
gradient
porous
scaffolds,
bioactive
material
coatings,
AI-assisted
design,
work
outlines
novel
strategies
improve
interventions.
These
advancements
not
only
enhance
efficacy
but
also
pave
way
findings
into
applications.
Polymers,
Год журнала:
2025,
Номер
17(2), С. 200 - 200
Опубликована: Янв. 14, 2025
Bone
tissue
engineering
aims
to
develop
biomaterials
that
are
capable
of
effectively
repairing
and
regenerating
damaged
bone
tissue.
Among
the
various
polymers
used
in
this
field,
polycaprolactone
(PCL)
is
one
most
widely
utilized.
As
a
biocompatible
polymer,
PCL
easy
fabricate,
cost-effective,
offers
consistent
quality
control,
making
it
popular
choice
for
biomedical
applications.
However,
lacks
inherent
antibacterial
properties,
susceptible
bacterial
adhesion
biofilm
formation,
which
can
lead
implant
failure.
To
address
issue,
study
enhance
properties
by
incorporating
calcium
phosphate
composite
(PCL_CaP)
nanostructures
onto
its
surface
via
hydrothermal
synthesis.
The
resulting
"PCL_CaP"
nanostructured
surfaces
exhibited
improved
wettability
demonstrated
mechano-bactericidal
potential
against
Escherichia
coli
Bacillus
subtilis.
flake-like
morphology
fabricated
CaP
disrupted
bacteria
membranes,
inhibiting
growth.
Furthermore,
supported
adhesion,
proliferation,
differentiation
pre-osteoblasts,
indicating
their
This
demonstrates
promise
as
an
effective
coating
implants
medical
devices,
with
further
research
required
evaluate
long-term
stability
vivo
performance.
Bioengineering,
Год журнала:
2025,
Номер
12(1), С. 71 - 71
Опубликована: Янв. 15, 2025
Three-dimensional
printing
was
introduced
in
the
1980s,
though
bioprinting
started
developing
a
few
years
later.
Today,
3D
is
making
inroads
medical
fields,
including
production
of
biomedical
supplies
intended
for
internal
use,
such
as
biodegradable
staples.
Medical
enables
versatility
and
flexibility
on
demand
able
to
modify
individualize
using
several
established
methods.
A
great
selection
biomaterials
bioinks
available,
natural,
synthetic,
mixed
options;
they
are
biocompatible
non-toxic.
Many
accommodate
cells
so
upon
implantation,
integrate
within
new
environment.
Bioprinting
suitable
tissues
living
or
viable
components,
collagen
scaffolding,
cartilage
cells,
also
parts
structures,
teeth,
artificial
man-made
materials
that
will
become
embedded
vivo.
an
integral
part
tissue
engineering
regenerative
medicine.
The
addition
newly
developed
smart
capable
incorporating
dynamic
changes
shape
depending
nature
stimuli
led
fourth
dimension
time
form
changing
three
static
dimensions.
Four-dimensional
already
significant
medicine,
ways
create
tissues.
Its
future
lies
constructing
partial
whole
organ
generation.
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
development
of
bioink-based
3D-printed
scaffolds
has
revolutionized
bone
tissue
engineering
(BTE)
by
enabling
patient-specific
and
biomimetic
constructs
for
regeneration.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 12, 2025
Mesenchymal
stem
cells
(MSCs)
play
a
crucial
role
in
bone
formation
and
remodeling.
Intrinsic
genetic
factors
extrinsic
environmental
cues
regulate
their
differentiation
into
osteoblasts.
Within
the
microenvironment,
complex
network
of
biochemical
biomechanical
signals
orchestrates
homeostasis
regeneration.
In
addition,
crosstalk
among
MSCs,
immune
cells,
neighboring
cells-mediated
by
extracellular
vesicles
non-coding
RNAs
(such
as
circular
micro
RNAs)
-profoundly
influences
osteogenic
Recent
studies
have
explored
specific
signaling
pathways
that
contribute
to
effective
regeneration,
highlighting
potential
manipulating
microenvironment
enhance
MSC
functionality.
The
integration
advanced
biomaterials,
gene
editing
techniques,
controlled
delivery
systems
is
paving
way
for
more
targeted
efficient
regenerative
therapies.
Furthermore,
artificial
intelligence
could
improve
tissue
engineering,
optimize
biomaterial
design,
enable
personalized
treatment
strategies.
This
review
explores
latest
advancements
emphasizing
intricate
interplay
molecules.
By
providing
comprehensive
overview
these
mechanisms
clinical
implications,
we
aim
shed
light
on
future
research
directions
this
rapidly
evolving
field.
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101341 - 101341
Опубликована: Ноя. 14, 2024
Bioprinting
and
bioinks
are
two
of
the
game
changers
in
bone
tissue
engineering.
This
review
presents
different
bioprinting
technologies
including
extrusion-based,
inkjet-based,
laser-assisted,
light-based,
hybrid
with
their
own
strengths
weaknesses.
will
aid
researchers
selection
assessment
bioink;
discussion
ranges
from
commercially
available
to
custom
lab-made
formulations
mainly
based
on
natural
polymers,
such
as
agarose,
alginate,
gelatin,
collagen,
chitosan,
designed
for
The
is
centered
technological
advancements
increasing
clinical
demand
within
rapidly
growing
market.
From
this
point
view,
4D,
5D,
6D
printing
promise
a
future
where
unprecedented
levels
innovation
be
involved
fabrication
processes
leading
more
dynamic
multifunctionalities
bioprinted
constructs.
Further
advances
technology,
methods
covered,
meet
personalized
medicine
goals
while
advancing
patient
outcomes
tissues
engineering
applications.
