Calcium Phosphate (CaP) Composite Nanostructures on Polycaprolactone (PCL): Synergistic Effects on Antibacterial Activity and Osteoblast Behavior

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 200 - 200

Published: Jan. 14, 2025

Bone tissue engineering aims to develop biomaterials that are capable of effectively repairing and regenerating damaged bone tissue. Among the various polymers used in this field, polycaprolactone (PCL) is one most widely utilized. As a biocompatible polymer, PCL easy fabricate, cost-effective, offers consistent quality control, making it popular choice for biomedical applications. However, lacks inherent antibacterial properties, susceptible bacterial adhesion biofilm formation, which can lead implant failure. To address issue, study enhance properties by incorporating calcium phosphate composite (PCL_CaP) nanostructures onto its surface via hydrothermal synthesis. The resulting "PCL_CaP" nanostructured surfaces exhibited improved wettability demonstrated mechano-bactericidal potential against Escherichia coli Bacillus subtilis. flake-like morphology fabricated CaP disrupted bacteria membranes, inhibiting growth. Furthermore, supported adhesion, proliferation, differentiation pre-osteoblasts, indicating their This demonstrates promise as an effective coating implants medical devices, with further research required evaluate long-term stability vivo performance.

Language: Английский

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Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

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Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3274 - 3274

Published: March 14, 2024

Throughout history, natural products have played a significant role in wound healing. Fibroblasts, acting as primary cellular mediators skin healing, exhibit behavioral responses to compounds that can enhance the healing process. Identifying bioactive and understanding their impact on fibroblast behavior offers crucial translational opportunities realm of Modern scientific techniques enabled detailed how naturally derived modulate by influencing behavior. Specific known for properties been identified. Engineered biomimetic replicating microenvironment are designed facilitate normal Advanced delivery methods operating at micro- nano-scales developed effectively deliver these novel through stratum corneum. This review provides comprehensive summary efficacy promoting regeneration repair. Additionally, it explores engineering, where researchers draw inspiration from nature create materials devices mimicking physiological cues effective The concludes describing mechanisms aimed enhancing bioavailability compounds. Innovative future strategies involve exploring fibroblast-influencing pathways, responsive biomaterials, smart dressings with real-time monitoring, applications stem cells. However, translating findings clinical settings faces challenges such limited validation biomaterials large animal models logistical obstacles industrial production. integration ancient remedies modern approaches holds promise achieving scar-free

Language: Английский

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Embryonic toxicology evaluation of novel Cissus quadrangularis, bioceramics and tendon extracellular matrix incorporated scaffolds for periodontal bone regeneration using zebrafish model

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(3), P. 563 - 569

Published: March 26, 2025

Language: Английский

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Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: a comprehensive review

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101341 - 101341

Published: Nov. 14, 2024

Bioprinting and bioinks are two of the game changers in bone tissue engineering. This review presents different bioprinting technologies including extrusion-based, inkjet-based, laser-assisted, light-based, hybrid with their own strengths weaknesses. will aid researchers selection assessment bioink; discussion ranges from commercially available to custom lab-made formulations mainly based on natural polymers, such as agarose, alginate, gelatin, collagen, chitosan, designed for The is centered technological advancements increasing clinical demand within rapidly growing market. From this point view, 4D, 5D, 6D printing promise a future where unprecedented levels innovation be involved fabrication processes leading more dynamic multifunctionalities bioprinted constructs. Further advances technology, methods covered, meet personalized medicine goals while advancing patient outcomes tissues engineering applications.

Language: Английский

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DFT theoretical and experimental investigation of gelatin-loaded niobium-doped calcium apatite ceramics to elucidate its structural and electronic characteristics

Next Materials, Journal Year: 2025, Volume and Issue: 7, P. 100630 - 100630

Published: April 1, 2025

Language: Английский

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The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. Intrinsic genetic factors extrinsic environmental cues regulate their differentiation into osteoblasts. Within the microenvironment, complex network of biochemical biomechanical signals orchestrates homeostasis regeneration. In addition, crosstalk among MSCs, immune cells, neighboring cells-mediated by extracellular vesicles non-coding RNAs (such as circular micro RNAs) -profoundly influences osteogenic Recent studies have explored specific signaling pathways that contribute to effective regeneration, highlighting potential manipulating microenvironment enhance MSC functionality. The integration advanced biomaterials, gene editing techniques, controlled delivery systems is paving way for more targeted efficient regenerative therapies. Furthermore, artificial intelligence could improve tissue engineering, optimize biomaterial design, enable personalized treatment strategies. This review explores latest advancements emphasizing intricate interplay molecules. By providing comprehensive overview these mechanisms clinical implications, we aim shed light on future research directions this rapidly evolving field.

Language: Английский

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Narrative Review and Guide: State of the Art and Emerging Opportunities of Bioprinting in Tissue Regeneration and Medical Instrumentation

Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 71 - 71

Published: Jan. 15, 2025

Three-dimensional printing was introduced in the 1980s, though bioprinting started developing a few years later. Today, 3D is making inroads medical fields, including production of biomedical supplies intended for internal use, such as biodegradable staples. Medical enables versatility and flexibility on demand able to modify individualize using several established methods. A great selection biomaterials bioinks available, natural, synthetic, mixed options; they are biocompatible non-toxic. Many accommodate cells so upon implantation, integrate within new environment. Bioprinting suitable tissues living or viable components, collagen scaffolding, cartilage cells, also parts structures, teeth, artificial man-made materials that will become embedded vivo. an integral part tissue engineering regenerative medicine. The addition newly developed smart capable incorporating dynamic changes shape depending nature stimuli led fourth dimension time form changing three static dimensions. Four-dimensional already significant medicine, ways create tissues. Its future lies constructing partial whole organ generation.

Language: Английский

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A new approach to bioceramics based on tissue reaction of tricalcium phosphate for biomedical and sport applications using machine learning modeling

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102899 - 102899

Published: April 1, 2025

Language: Английский

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Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Language: Английский

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