Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

и другие.

ACS Materials Au, Год журнала: 2024, Номер 5(1), С. 115 - 140

Опубликована: Ноя. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Язык: Английский

AI-Driven Innovation in Skin Kinetics for Transdermal Drug Delivery: Overcoming Barriers and Enhancing Precision DOI Creative Commons

Nubul Albayati,

Sesha Rajeswari Talluri,

Nirali Dholaria

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 188 - 188

Опубликована: Фев. 2, 2025

Transdermal drug delivery systems (TDDS) offer an alternative to conventional oral and injectable administration by bypassing the gastrointestinal tract liver metabolism, improving bioavailability, minimizing systemic side effects. However, widespread adoption of TDDS is limited challenges such as skin’s permeability barrier, particularly stratum corneum, need for optimized formulations. Factors like skin type, hydration levels, age further complicate development universally effective solutions. Advances in artificial intelligence (AI) address these through predictive modeling personalized medicine approaches. Machine learning models trained on extensive molecular datasets predict accelerate selection suitable candidates. AI-driven algorithms optimize formulations, including penetration enhancers advanced technologies microneedles liposomes, while ensuring safety efficacy. Personalized design tailors individual patient profiles, enhancing therapeutic precision. Innovative systems, sensor-integrated patches, dynamically adjust release based real-time feedback, optimal outcomes. AI also streamlines pharmaceutical process, from disease diagnosis prediction distribution layers, enabling efficient formulation development. This review highlights AI’s transformative role TDDS, applications Deep Neural Networks (DNN), Artificial (ANN), BioSIM, COMSOL, K-Nearest Neighbors (KNN), Set Covering (SVM). These revolutionize both non-skin diseases, demonstrating potential overcome existing barriers improve care innovative

Язык: Английский

Процитировано

0
3D-printed microneedles for sensing applications: emerging topics and future trends DOI Creative Commons
Kelcilene B. R. Teodoro, Tamires S. Pereira, Ana Laura M.M. Alves

и другие.

Advanced Sensor and Energy Materials, Год журнала: 2025, Номер unknown, С. 100139 - 100139

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

и другие.

ACS Materials Au, Год журнала: 2024, Номер 5(1), С. 115 - 140

Опубликована: Ноя. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Язык: Английский

Процитировано

0