AI-Driven Innovation in Skin Kinetics for Transdermal Drug Delivery: Overcoming Barriers and Enhancing Precision
Nubul Albayati,
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Sesha Rajeswari Talluri,
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Nirali Dholaria
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et al.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 188 - 188
Published: Feb. 2, 2025
Transdermal
drug
delivery
systems
(TDDS)
offer
an
alternative
to
conventional
oral
and
injectable
administration
by
bypassing
the
gastrointestinal
tract
liver
metabolism,
improving
bioavailability,
minimizing
systemic
side
effects.
However,
widespread
adoption
of
TDDS
is
limited
challenges
such
as
skin’s
permeability
barrier,
particularly
stratum
corneum,
need
for
optimized
formulations.
Factors
like
skin
type,
hydration
levels,
age
further
complicate
development
universally
effective
solutions.
Advances
in
artificial
intelligence
(AI)
address
these
through
predictive
modeling
personalized
medicine
approaches.
Machine
learning
models
trained
on
extensive
molecular
datasets
predict
accelerate
selection
suitable
candidates.
AI-driven
algorithms
optimize
formulations,
including
penetration
enhancers
advanced
technologies
microneedles
liposomes,
while
ensuring
safety
efficacy.
Personalized
design
tailors
individual
patient
profiles,
enhancing
therapeutic
precision.
Innovative
systems,
sensor-integrated
patches,
dynamically
adjust
release
based
real-time
feedback,
optimal
outcomes.
AI
also
streamlines
pharmaceutical
process,
from
disease
diagnosis
prediction
distribution
layers,
enabling
efficient
formulation
development.
This
review
highlights
AI’s
transformative
role
TDDS,
applications
Deep
Neural
Networks
(DNN),
Artificial
(ANN),
BioSIM,
COMSOL,
K-Nearest
Neighbors
(KNN),
Set
Covering
(SVM).
These
revolutionize
both
non-skin
diseases,
demonstrating
potential
overcome
existing
barriers
improve
care
innovative
Language: Английский
3D-printed microneedles for sensing applications: emerging topics and future trends
Advanced Sensor and Energy Materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100139 - 100139
Published: Feb. 1, 2025
Language: Английский
Microneedle-Based Delivery of Metal Oxide Nanoparticles
Series in bioengineering,
Journal Year:
2025,
Volume and Issue:
unknown, P. 299 - 315
Published: Jan. 1, 2025
Language: Английский
The Future of Alopecia Treatment: Plant Extracts, Nanocarriers, and 3D Bioprinting in Focus
Rana E. Elnady,
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Manar S. Abdon,
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Hagar R. Shaheen
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et al.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 584 - 584
Published: April 29, 2025
Alopecia
is
a
concerning
dermatological
issue
and
also
known
as
alopecia.
This
disease
can
affect
men
women,
influencing
their
confidence
appearance.
It
targets
the
scalp
or
any
area
of
entire
body.
has
become
widespread
worldwide
over
years
many
types
different
causes:
hereditary,
hormonal,
immunological,
therapeutic,
psychological.
review
will
present
comprehensive
study
physiological
structure
hair
growth
shedding
phases.
discusses
using
nano-drug
delivery
systems
that
contain
natural
substances
plant
origin,
which
are
effective,
less
harmful
compared
to
current
treatments,
help
avoid
adverse
effects.
covers
latest
trends
in
treating
alopecia,
including
drug
systems,
materials
methods
used
prepare
these
three-dimensional
(3D)
bioprinting
strategies,
extracts
may
be
utilized
for
treatment
coming
years.
Language: Английский
Microneedle drug delivery carriers capable of achieving sustained and controlled release function
Guangxi Zhai,
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Jiayi Shao,
No information about this author
Yunshu Xu
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et al.
Colloids and Surfaces B Biointerfaces,
Journal Year:
2025,
Volume and Issue:
253, P. 114767 - 114767
Published: May 6, 2025
Language: Английский
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review
Rashmi Hulimane Shivaswamy,
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Pranav Binulal,
No information about this author
Aloysious Benoy
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et al.
ACS Materials Au,
Journal Year:
2024,
Volume and Issue:
5(1), P. 115 - 140
Published: Nov. 28, 2024
The
delivery
of
molecules,
such
as
DNA,
RNA,
peptides,
and
certain
hydrophilic
drugs,
across
the
epidermal
barrier
poses
a
significant
obstacle.
Microneedle
technology
has
emerged
prominent
area
focus
in
biomedical
research
because
its
ability
to
deliver
wide
range
biomolecules,
vaccines,
medicines,
other
substances
through
skin.
Microneedles
(MNs)
form
microchannels
by
disrupting
skin's
structure,
which
compromises
function,
facilitating
easy
penetration
drugs
into
These
devices
enhance
administration
many
therapeutic
skin,
enhancing
their
stability.
Transcutaneous
medications
using
microneedle
patch
offers
advantages
over
conventional
drug
methods.
containing
active
can
be
stimulated
different
internal
external
factors
result
regulated
release
substances.
To
achieve
efficient
desired
location,
it
is
necessary
consider
design
needles
with
appropriate
optimized
characteristics.
choice
materials
for
developing
manufacturing
these
vital
determining
pharmacodynamics
pharmacokinetics
delivery.
This
article
provides
most
recent
update
overview
numerous
systems
that
utilize
activators
stimulate
components
from
microneedles.
Further,
discusses
utilized
producing
microneedles
strategies
important
managing
drugs.
An
explanation
commonly
employed
fabrication
techniques
applications
electronics,
particularly
integrated
systems,
discussed.
successfully
implement
clinical
settings,
essential
comprehensively
assess
several
factors,
biocompatibility,
stability,
safety,
production
cost.
Finally,
an
in-depth
review
criteria
difficulties
potential
future
direction
delivering
monitoring
diseases
explored.
Language: Английский