Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

et al.

ACS Materials Au, Journal Year: 2024, Volume and Issue: 5(1), P. 115 - 140

Published: Nov. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Language: Английский

AI-Driven Innovation in Skin Kinetics for Transdermal Drug Delivery: Overcoming Barriers and Enhancing Precision DOI Creative Commons

Nubul Albayati,

Sesha Rajeswari Talluri,

Nirali Dholaria

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 188 - 188

Published: Feb. 2, 2025

Transdermal drug delivery systems (TDDS) offer an alternative to conventional oral and injectable administration by bypassing the gastrointestinal tract liver metabolism, improving bioavailability, minimizing systemic side effects. However, widespread adoption of TDDS is limited challenges such as skin’s permeability barrier, particularly stratum corneum, need for optimized formulations. Factors like skin type, hydration levels, age further complicate development universally effective solutions. Advances in artificial intelligence (AI) address these through predictive modeling personalized medicine approaches. Machine learning models trained on extensive molecular datasets predict accelerate selection suitable candidates. AI-driven algorithms optimize formulations, including penetration enhancers advanced technologies microneedles liposomes, while ensuring safety efficacy. Personalized design tailors individual patient profiles, enhancing therapeutic precision. Innovative systems, sensor-integrated patches, dynamically adjust release based real-time feedback, optimal outcomes. AI also streamlines pharmaceutical process, from disease diagnosis prediction distribution layers, enabling efficient formulation development. This review highlights AI’s transformative role TDDS, applications Deep Neural Networks (DNN), Artificial (ANN), BioSIM, COMSOL, K-Nearest Neighbors (KNN), Set Covering (SVM). These revolutionize both non-skin diseases, demonstrating potential overcome existing barriers improve care innovative

Language: Английский

Citations

1
3D-printed microneedles for sensing applications: emerging topics and future trends DOI Creative Commons
Kelcilene B. R. Teodoro, Tamires S. Pereira, Ana Laura M.M. Alves

et al.

Advanced Sensor and Energy Materials, Journal Year: 2025, Volume and Issue: unknown, P. 100139 - 100139

Published: Feb. 1, 2025

Language: Английский

Citations

0
Microneedle-Based Delivery of Metal Oxide Nanoparticles DOI
Jaison Jeevanandam, Tracy Ann Bruce‐Tagoe, Michael K. Danquah

et al.

Series in bioengineering, Journal Year: 2025, Volume and Issue: unknown, P. 299 - 315

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Future of Alopecia Treatment: Plant Extracts, Nanocarriers, and 3D Bioprinting in Focus DOI Creative Commons
Rana E. Elnady,

Manar S. Abdon,

Hagar R. Shaheen

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 584 - 584

Published: April 29, 2025

Alopecia is a concerning dermatological issue and also known as alopecia. This disease can affect men women, influencing their confidence appearance. It targets the scalp or any area of entire body. has become widespread worldwide over years many types different causes: hereditary, hormonal, immunological, therapeutic, psychological. review will present comprehensive study physiological structure hair growth shedding phases. discusses using nano-drug delivery systems that contain natural substances plant origin, which are effective, less harmful compared to current treatments, help avoid adverse effects. covers latest trends in treating alopecia, including drug systems, materials methods used prepare these three-dimensional (3D) bioprinting strategies, extracts may be utilized for treatment coming years.

Language: Английский

Citations

0
Microneedle drug delivery carriers capable of achieving sustained and controlled release function DOI

Guangxi Zhai,

Jiayi Shao,

Yunshu Xu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114767 - 114767

Published: May 6, 2025

Language: Английский

Citations

0
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review DOI Creative Commons

Rashmi Hulimane Shivaswamy,

Pranav Binulal,

Aloysious Benoy

et al.

ACS Materials Au, Journal Year: 2024, Volume and Issue: 5(1), P. 115 - 140

Published: Nov. 28, 2024

The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged prominent area focus in biomedical research because its ability to deliver wide range biomolecules, vaccines, medicines, other substances through skin. Microneedles (MNs) form microchannels by disrupting skin's structure, which compromises function, facilitating easy penetration drugs into These devices enhance administration many therapeutic skin, enhancing their stability. Transcutaneous medications using microneedle patch offers advantages over conventional drug methods. containing active can be stimulated different internal external factors result regulated release substances. To achieve efficient desired location, it is necessary consider design needles with appropriate optimized characteristics. choice materials for developing manufacturing these vital determining pharmacodynamics pharmacokinetics delivery. This article provides most recent update overview numerous systems that utilize activators stimulate components from microneedles. Further, discusses utilized producing microneedles strategies important managing drugs. An explanation commonly employed fabrication techniques applications electronics, particularly integrated systems, discussed. successfully implement clinical settings, essential comprehensively assess several factors, biocompatibility, stability, safety, production cost. Finally, an in-depth review criteria difficulties potential future direction delivering monitoring diseases explored.

Language: Английский

Citations

2