Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 409 - 428
Опубликована: Дек. 17, 2024
The
advent
of
precision
oncology
has
brought
about
a
paradigm
shift
in
the
management
cancer,
with
increased
emphasis
on
personalized
treatment
approaches.
key
aspects
this
approach
are
to
identify
spatially
variable
genes,
which
exhibit
significant
expression
differences
across
distinct
regions
tumor.
These
genes
have
emerged
as
potential
therapeutic
targets
and
biomarkers
they
reflect
inherent
heterogeneity
within
disease.
By
capturing
spatial
variability
gene
tumor,
researchers
clinicians
learn
important
things
underlying
biology
develop
more
targeted
effective
strategies
for
individual
patients.
recent
advances
associated
methods
main
topics
chapter.
understanding
how
varies
tumors,
we
can
potentially
improve
diagnostic
accuracy,
efficacy,
patient
outcomes
oncology.
Biosensors and Bioelectronics,
Год журнала:
2024,
Номер
250, С. 116079 - 116079
Опубликована: Янв. 28, 2024
Following
the
global
COVID-19
pandemic
triggered
by
SARS-CoV-2,
need
for
rapid,
specific
and
cost-effective
point-of-care
diagnostic
solutions
remains
paramount.
Even
though
is
no
longer
a
public
health
emergency,
disease
still
poses
threat
leading
to
deaths,
it
continues
change
with
risk
of
new
variants
emerging
causing
surge
in
cases
deaths.
Here,
we
address
urgent
SARS-CoV-2.
We
propose
multiplexed
DNA-based
sensing
platform
that
utilizes
inkjet-printed
nanostructured
gold
electrodes
an
battery-free
near-field
communication
(NFC)
potentiostat
simultaneous
quantitative
detection
two
SARS-CoV-2
genes,
ORF1ab
N
gene.
The
strategy
based
on
formation
RNA-DNA
sandwich
structure
leads
highly
electrochemical
output.
providing
large
surface
area
enable
efficient
binding
increase
sensitivity.
NFC
enables
rapid
measurements
real-time
data
analysis
via
smartphone
application,
making
accessible
portable.
With
advantages
speed
(5
min),
simplicity,
sensitivity
(low
pM
range,
∼450%
signal
gain)
cost-effectiveness,
proposed
promising
alternative
diagnostics
high-throughput
complements
toolkit.
Clinical Breast Cancer,
Год журнала:
2024,
Номер
24(6), С. e429 - e451
Опубликована: Март 6, 2024
BackgroundNUDCD1
(NudC
Domain
Containing
1)
performs
an
essential
function
in
biological
processes
such
as
cell
progression,
migration,
cycle,
and
intracellular
material
transport.
Many
solid
tumors
express
it
highly,
which
is
a
prospective
biomarker
therapeutic
approach.
However,
the
expression
clinical
importance
of
NUDCD1
across
breast
cancer
unclear.MethodsThe
expressions
cancers
normal
tissues
were
studied
utilizing
TIMER
database
immunohistochemical
analysis.
Subsequently,
we
validate
association
between
clinicopathologic
features
prognosis
cancer.
The
experiments
pathway-related
molecules
done
on
214
tissue
microarrays.
investigation
correlation
tumor
immune
infiltration
was
subsequently
conducted.ResultsThrough
utilization
bioinformatics
analysis
experiments,
determined
that
exhibited
upregulation
within
Furthermore,
discovered
elevated
may
potentially
be
linked
to
worse
Our
study
reveals
PI3K/AKT/mTOR
signaling
pathway
perform
regulating
progression
via
enrichment
associated
with
degree
immunological
infiltration.ConclusionThe
explored
observed
correlated
poorer
prognosis.
p-AKT,
PI3K,
AKT,
mTOR,
p-mTOR
levels
underwent
significant
elevation
might
pathway.Micro
AbstractBreast
one
most
common
malignant
women.
In
this
study,
analyzed
1226
cases
using
methods
respectively.
found
highly
expressed
poor
It
new
target
for
patients.
Biosensors,
Год журнала:
2025,
Номер
15(4), С. 221 - 221
Опубликована: Март 31, 2025
Transcription
factor-based
biosensors
(TFBs)
are
powerful
tools
in
microbial
biosensor
applications,
enabling
dynamic
control
of
metabolic
pathways,
real-time
monitoring
intracellular
metabolites,
and
high-throughput
screening
(HTS)
for
strain
engineering.
These
systems
use
transcription
factors
(TFs)
to
convert
metabolite
concentrations
into
quantifiable
outputs,
precise
regulation
fluxes
biosynthetic
efficiency
cell
factories.
Recent
advancements
TFB,
including
improved
sensitivity,
specificity,
range,
have
broadened
their
applications
synthetic
biology
industrial
biotechnology.
Computational
such
as
Cello
further
revolutionized
TFB
design,
silico
optimization
construction
complex
genetic
circuits
integrating
multiple
signals
achieving
gene
regulation.
This
review
explores
innovations
biosensors,
role
engineering
adaptive
evolution,
future
integration
with
artificial
intelligence
advanced
technologies
overcome
critical
challenges
bioproduction.
Abstract
Thyroid
cancer
(TC)
is
a
common
endocrine
malignancy
with
an
increasing
incidence
worldwide.
Early
diagnosis
particularly
important
for
TC
patients,
because
it
allows
patients
to
receive
treatment
as
early
possible.
Artificial
intelligence
(AI)
provides
great
advantages
complex
healthcare
systems
by
analyzing
big
data
based
on
machine
learning.
Nowadays,
AI
widely
used
in
the
of
such
TC.
Ultrasound
detection
and
fine
needle
aspiration
biopsy
are
main
methods
has
been
thyroid
nodules
ultrasound
images,
cytopathology
images
molecular
markers.
It
shows
potential
auxiliary
medical
diagnosis.
The
latest
clinical
trial
shown
that
performance
models
matches
diagnostic
efficiency
experienced
clinicians,
more
efficient
tools
will
be
developed
future.
Therefore,
this
review,
we
summarized
recent
advances
application
algorithms
assessing
risk
nodules.
objective
review
was
provide
base
use
AI-assisted
TC,
well
new
ideas
next
generation
Medicine,
Год журнала:
2023,
Номер
102(41), С. e35539 - e35539
Опубликована: Окт. 13, 2023
Neutrophil
gelatinase-associated
lipocalin
(NGAL,
also
known
as
lipocalin-2)
is
an
acute-phase
protein
expressed
in
many
tissues
and
plays
a
role
cell
proliferation,
regulation,
epithelial-mesenchymal
transformation.
Therefore,
this
study
aimed
to
investigate
serum
NGAL
levels
endometrioma
tissue
expression
women
with
endometriosis.
This
cross-sectional
was
conducted
at
university
hospital.
The
group
included
36
who
underwent
ovarian
cystectomy
for
endometrioma,
which
compared
control
(n
=
36)
of
due
benign
persistent
cysts
(follicle
cyst,
theca
lutein
serous
cystadenoma).
were
analyzed
using
both
enzyme-linked
immunosorbent
assay
analysis
immunohistochemical
staining.
Serum
C-reactive
CA-125
evaluated.
significantly
higher
the
than
(
P
<
.05).
.05)
correlated
levels.
Immunohistochemical
staining
.001).
may
be
considered
potential
noninvasive
biomarker
