International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3421 - 3421
Опубликована: Апрель 5, 2025
Breast
milk
exosomes
are
essential
for
the
nutrition
and
immune
development
of
newborn.
These
30-150
nm
extracellular
vesicles
contain
microRNAs
(miRNAs),
mesessenger
RNAS
(mRNA)s,
proteins
lipids
that
facilitate
cellular
communication
modulate
neonatal
system.
In
this
article,
we
analyse
impact
breast
on
intestinal
microbiota
newborn,
especially
in
high-risk
neonates
such
as
preterm
infants
or
at
risk
necrotising
enterocolitis
(NEC).
Exosomes
promote
colonisation
beneficial
bacteria
Bifidobacterium
Lactobacillus
strengthen
barrier.
They
also
regulate
response,
balancing
defence
against
pathogens
tolerance
to
non-pathogenic
antigens.
This
effect
is
key
infants,
who
benefit
from
their
anti-inflammatory
preventive
properties
complications
NEC.
Research
points
potential
therapeutic
uses
care,
opening
up
new
opportunities
improve
health
vulnerable
newborns
through
protective
effects
exosomes.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 27, 2023
Spinal
cord
injury
(SCI)
remains
a
significant
health
concern,
with
limited
available
treatment
options.
This
condition
poses
medical,
economic,
and
social
challenges.
SCI
is
typically
categorized
into
primary
secondary
injuries.
Inflammation,
oxidative
stress,
scar
formation,
the
immune
microenvironment
impede
axon
regeneration
subsequent
functional
restoration.
Numerous
studies
have
shown
that
destruction
of
blood-brain
barrier
(BBB)
microvessels
crucial
factor
in
severe
injury.
Additionally,
reactive
oxygen
species
(ROS)-induced
lipid
peroxidation
significantly
contributes
to
endothelial
cell
death.
Pericytes
are
essential
constituents
BBB
share
basement
membrane
cells
astrocytes.
They
play
role
establishment
maintenance
BBB.Immunofluorescence
staining
at
different
time
points
revealed
consistent
correlation
between
pericyte
coverage
angiogenesis,
suggesting
pericytes
promote
vascular
repair
via
paracrine
signaling.
undergo
alterations
cellular
morphology
transcriptome
when
exposed
hypoxic
conditions,
potentially
promoting
angiogenesis.
We
simulated
an
early
ischemia-hypoxic
environment
following
using
glucose
deprivation
models.
Co-culturing
improved
function
compared
control
group.
However,
this
enhancement
was
reduced
by
exosome
inhibitor,
GW4869.
In
vivo
injection
exosomes
integrity
promoted
motor
recovery
mice
SCI.
Subsequently,
we
found
pericyte-derived
exhibited
miR-210-5p
expression
based
on
sequencing
analysis.
Therefore,
performed
series
gain-
loss-of-function
experiments
vitro.Our
findings
suggest
regulates
inhibiting
JAK1/STAT3
process
achieved
regulating
levels
improving
mitochondrial
function,
potential
mechanism
for
restoration
blood-spinal
(BSCB)
after
Biosensors and Bioelectronics X,
Год журнала:
2024,
Номер
19, С. 100489 - 100489
Опубликована: Май 22, 2024
This
article
has
tried
to
provide
an
overview
of
the
most
sophisticated
microfluidic
biosensors
for
identifying
nucleic
acids
and
proteins
at
site
treatment.
Microfluidics,
which
also
automates
sample
preparation
reduces
processing
time
reagent
consumption,
enables
analysis
small
quantities.
Microfluidics
biosensor
technologies
collaborate
diagnostics
point
care
with
high
throughput
analysis,
portability,
disposability.
The
sensitivity
selectivity
requirements,
false
response
errors,
integration
other
essential
modules
are
some
challenges
posed
by
this
merger.
broad
categories
protein-based
DNA-based
technology
covered
in
review.
Also,
recent
advancements
coupling
microfluidics,
main
potential
solutions
deploying
point-of-care
diagnostics,
developments
these
areas
have
been
discussed.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 30, 2024
Abstract
The
advancement
of
nanoscience
and
material
design
in
recent
times
has
facilitated
the
creation
point-of-care
devices
for
cancer
diagnosis
biomolecule
sensing.
Exosomes
(EXOs)
facilitate
transfer
bioactive
molecules
between
cells
diverse
local
distant
microenvironments,
thereby
contributing
to
progression
metastasis.
Specifically,
EXOs
derived
from
are
likely
function
as
biomarkers
early
detection
due
genetic
or
signaling
alterations
they
transport
payload
within
origin.
It
been
verified
that
circulate
steadily
bodily
secretions
contain
a
variety
information
indicates
tumor.
However,
acquiring
molecular
interactions
regarding
presented
significant
technical
challenges
their
nanoscale
nature
high
heterogeneity.
Colorimetry,
surface
plasmon
resonance
(SPR),
fluorescence,
Raman
scattering
examples
optical
techniques
utilized
quantify
exosomal
biomarkers,
including
lipids,
proteins,
RNA,
DNA.
Many
optically
active
nanoparticles
(NPs),
predominantly
carbon-based,
inorganic,
organic,
composite-based
nanomaterials,
have
employed
biosensing
technology.
exceptional
physical
properties
exhibited
by
carbon
NPs,
noble
metal
magnetic
progress
development
nanobiosensors
intended
originating
tumors.
Following
summary
biogenesis,
biological
functions,
biomarker
value
known
EXOs,
this
article
provides
an
update
on
methodologies
currently
under
investigation.
In
conclusion,
we
propose
some
potential
enhancements
biosensors
detecting
EXO,
utilizing
various
NP
materials
such
silicon
graphene
oxide
(GO),
quantum
dots
(QDs).
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
178, С. 117248 - 117248
Опубликована: Авг. 3, 2024
Exosome-nanoparticle
hybrid
nanoplatforms,
can
be
prepared
by
combining
exosomes
with
different
types
of
nanoparticles.
The
main
purpose
nanoparticles
is
to
overcome
the
limitations
using
each
them
as
drug
delivery
systems.
Using
for
has
some
limitations,
such
high
immunogenicity,
poor
cellular
uptake,
low
biocompatibility,
cytotoxicity,
stability,
and
rapid
clearance
immune
cells.
However,
systems
also
its
own
drawbacks,
encapsulation
efficiency,
production
yield,
inability
load
large
molecules.
These
addressed
utilizing
nanoplatforms.
Additionally,
use
allows
targeted
within
system.
Exosome-inorganic/organic
may
used
both
therapy
diagnosis
in
future.
This
lead
development
personalized
medicine
there
are
a
few
challenges
associated
this.
Surface
modifications,
adding
functional
groups,
surface
charge
adjustments,
preparing
desired
size
crucial
possibility
exosome-nanoparticle
hybrids.
Additional
successful
implementation
platforms
medical
treatments
diagnostics
include
scaling
up
manufacturing
process
ensuring
consistent
quality
reproducibility
across
various
batches.
review
focuses
on
discusses
preparation
loading
methods
these
Furthermore,
potential
applications
nanocarriers
drug/gene
delivery,
disease
treatment
diagnosis,
cell/tissue
imaging
explained.
Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 17, 2024
Cancer-derived
exosomes
carry
a
large
number
of
specific
molecular
profiles
from
cancer
cells
and
have
emerged
as
ideal
biomarkers
for
early
diagnosis.
Accurate
detection
ultralow-abundance
in
complex
biological
samples
remains
great
challenge.
Herein,
novel
SERS
aptasensor
powered
by
cascaded
signal
amplification
CRISPR/Cas13a
Biological Procedures Online,
Год журнала:
2023,
Номер
25(1)
Опубликована: Ноя. 13, 2023
Non-small
cell
lung
cancer
(NSCLC)
remains
a
leading
cause
of
cancer-related
deaths
worldwide,
primarily
due
to
its
propensity
for
metastasis.
Patients
diagnosed
with
localized
primary
have
higher
survival
rates
than
those
Thus,
it
is
imperative
discover
biomarkers
the
early
detection
NSCLC
and
timely
prediction
tumor
metastasis
improve
patient
outcomes.
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 51 - 51
Опубликована: Янв. 2, 2025
Psoriasis
is
a
chronic,
recurrent
and
inflammatory
skin
disease.
Although
conventional
immunosuppressants
can
ameliorate
psoriatic
symptoms,
it
tends
to
relapse
over
time.
Previous
studies
have
shown
that
exosomes
from
both
immune
non-immune
cells
participate
in
immunopathology.
The
biologically
active
cargoes
accelerate
psoriasis
progression
by
altering
gene
profiles
signaling
pathways
of
neighboring
cells.
On
the
other
hand,
be
utilized
as
drug
delivery
platforms
for
treatment.
Especially,
engineered
may
serve
systems
effective
proteins,
nucleic
acids
or
drugs
due
their
low
immunogenicity,
good
stability
ability
fuse
with
target
Therefore,
investigation
into
mechanisms
underlying
intercellular
communications
mediated
lesions
likely
helps
design
therapy
psoriasis.
In
this
review,
we
summarized
recent
advances
biogenesis
potential
roles
pathogenesis
treatment
further
discussed
challenges
future
directions
particular,
review
highlights
immunoregulatory
function
derived
exosome-based
therapeutic
applications
psoriasis,
including
systems.
Thus,
help
