International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8245 - 8245
Опубликована: Июль 28, 2024
Neurological
symptoms
associated
with
COVID-19,
acute
and
long
term,
suggest
SARS-CoV-2
affects
both
the
peripheral
central
nervous
systems
(PNS/CNS).
Although
studies
have
shown
olfactory
hematogenous
invasion
into
CNS,
coinciding
neuroinflammation,
little
attention
has
been
paid
to
susceptibility
of
PNS
infection
or
its
contribution
CNS
invasion.
Here
we
show
that
sensory
autonomic
neurons
in
are
susceptible
productive
outline
physiological
molecular
mechanisms
mediating
neuroinvasion.
Our
K18-hACE2
mice,
wild-type
golden
Syrian
hamsters,
as
well
primary
neuronal
cultures,
viral
RNA,
proteins,
infectious
virus
neurons,
satellite
glial
cells,
functionally
connected
tissues.
Additionally,
demonstrate,
vitro,
neuropilin-1
facilitates
entry.
rapidly
invades
prior
viremia,
establishes
a
results
often
reported
by
COVID-19
patients.
Journal of Microbiology Immunology and Infection,
Год журнала:
2022,
Номер
56(1), С. 1 - 9
Опубликована: Окт. 15, 2022
At
present,
there
are
more
than
560
million
confirmed
cases
of
the
coronavirus
disease
2019
(COVID-19)
worldwide.
Although
98%
patients
with
severe
acute
respiratory
syndrome-coronavirus
2
(SARS-CoV-2)
infection
can
survive
COVID,
a
significant
portion
survivors
develop
residual
health
problems,
which
is
termed
as
long
COVID.
COVID-19
generally
associated
high
risk
asymptomatic
or
mild
also
show
The
definition
COVID
inconsistent
and
its
clinical
manifestations
protean.
In
addition
to
general
symptoms,
such
fatigue,
affect
many
organ
systems,
including
respiratory,
neurological,
psychosocial,
cardiovascular,
gastrointestinal,
metabolic
systems.
Moreover,
may
experience
exercise
intolerance
impaired
daily
function
quality
life.
Long
be
caused
by
SARS-CoV-2
direct
injury
immune/inflammatory
response.
Assessment
requires
comprehensive
evaluation,
history
taking,
physical
examination,
laboratory
tests,
radiography,
functional
tests.
However,
no
known
effective
treatment
for
Based
on
limited
evidence,
vaccines
help
prevent
development
As
new
entity
that
constantly
evolving,
still
unknowns,
further
investigation
warranted
enhance
our
understanding
this
disease.
Cell Death and Differentiation,
Год журнала:
2022,
Номер
unknown
Опубликована: Сен. 7, 2022
Abstract
Post-acute
sequelae
of
SARS-CoV-2
(PASC),
also
known
as
Post-Covid
Syndrome,
and
colloquially
Long
Covid,
has
been
defined
a
constellation
signs
symptoms
which
persist
for
weeks
or
months
after
the
initial
infection.
PASC
affects
wide
range
diverse
organs
systems,
with
manifestations
involving
lungs,
brain,
cardiovascular
system
other
such
kidney
neuromuscular
system.
The
pathogenesis
is
complex
multifactorial.
Evidence
suggests
that
seeding
persistence
in
different
organs,
reactivation,
response
to
unrelated
viruses
EBV,
autoimmunity,
uncontrolled
inflammation
are
major
drivers
PASC.
relative
importance
pathogenetic
pathways
may
differ
tissue
organ
contexts.
vaccination,
addition
protecting
against
disease,
reduces
breakthrough
infection
although
its
actual
impact
remains
be
defined.
represents
formidable
challenge
health
care
systems
dissecting
mechanisms
pave
way
targeted
preventive
therapeutic
approaches.
Neurology International,
Год журнала:
2023,
Номер
15(3), С. 821 - 841
Опубликована: Июль 6, 2023
SARS-CoV-2,
a
single-stranded
RNA
coronavirus,
causes
an
illness
known
as
coronavirus
disease
2019
(COVID-19).
Long-term
complications
are
increasing
issue
in
patients
who
have
been
infected
with
COVID-19
and
may
be
result
of
viral-associated
systemic
central
nervous
system
inflammation
or
arise
from
virus-induced
hypercoagulable
state.
incite
changes
brain
function
wide
range
lingering
symptoms.
Patients
often
experience
fatigue
note
fog,
sensorimotor
symptoms,
sleep
disturbances.
Prolonged
neurological
neuropsychiatric
symptoms
prevalent
can
interfere
substantially
everyday
life,
leading
to
massive
public
health
concern.
The
mechanistic
pathways
by
which
SARS-CoV-2
infection
sequelae
important
subject
ongoing
research.
Inflammation-
induced
blood-brain
barrier
permeability
viral
neuro-invasion
direct
nerve
damage
involved.
Though
the
mechanisms
uncertain,
resulting
documented
numerous
patient
reports
studies.
This
review
examines
constellation
spectrum
seen
long
COVID
incorporates
information
on
prevalence
these
contributing
factors,
typical
course.
Although
treatment
options
generally
lacking,
potential
therapeutic
approaches
for
alleviating
improving
quality
life
explored.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 4, 2024
The
coronavirus
disease
2019
(COVID-19)
pandemic
caused
by
SARS-CoV-2
has
been
defined
as
the
greatest
global
health
and
socioeconomic
crisis
of
modern
times.
While
most
people
recover
after
being
infected
with
virus,
a
significant
proportion
them
continue
to
experience
issues
weeks,
months
even
years
acute
infection
SARS-CoV-2.
This
persistence
clinical
symptoms
in
individuals
for
at
least
three
onset
or
emergence
new
lasting
more
than
two
months,
without
any
other
explanation
alternative
diagnosis
have
named
long
COVID,
long-haul
post-COVID-19
conditions,
chronic
post-acute
sequelae
(PASC).
Long
COVID
characterized
constellation
disorders
that
vary
widely
their
manifestations.
Further,
mechanisms
underlying
are
not
fully
understood,
which
hamper
efficient
treatment
options.
review
describes
predictors
common
related
COVID's
effects
on
central
peripheral
nervous
system
organs
tissues.
Furthermore,
transcriptional
markers,
molecular
signaling
pathways
risk
factors
such
sex,
age,
pre-existing
condition,
hospitalization
during
phase
COVID-19,
vaccination,
lifestyle
presented.
Finally,
recommendations
patient
rehabilitation
management,
well
therapeutical
approaches
discussed.
Understanding
complexity
this
disease,
its
across
multiple
organ
systems
overlapping
pathologies
possible
paramount
developing
diagnostic
tools
treatments.
Neuroepidemiology,
Год журнала:
2024,
Номер
58(2), С. 120 - 133
Опубликована: Янв. 1, 2024
<b><i>Introduction:</i></b>
The
aim
of
this
systematic
review
and
meta-analysis
was
to
evaluate
the
prevalence
thirteen
neurological
manifestations
in
people
affected
by
COVID-19
during
acute
phase
at
3,
6,
9
12-month
follow-up
time
points.
<b><i>Methods:</i></b>
study
protocol
registered
with
PROSPERO
(CRD42022325505).
MEDLINE
(PubMed),
Embase,
Cochrane
Library
were
used
as
information
sources.
Eligible
studies
included
original
articles
cohort
studies,
case-control
cross-sectional
case
series
≥5
subjects
that
reported
type
manifestations,
a
minimum
3
months
after
disease.
Two
independent
reviewers
screened
from
January
1,
2020,
June
16,
2022.
following
assessed:
neuromuscular
disorders,
encephalopathy/altered
mental
status/delirium,
movement
dysautonomia,
cerebrovascular
cognitive
impairment/dementia,
sleep
seizures,
syncope/transient
loss
consciousness,
fatigue,
gait
disturbances,
anosmia/hyposmia,
headache.
pooled
their
95%
confidence
intervals
calculated
six
pre-specified
times.
<b><i>Results:</i></b>
126
6,565
fulfilled
eligibility
criteria,
accounting
for
1,542,300
Of
these,
four
only
data
on
conditions
other
than
13
selected.
disorders
highest
estimates
(per
100
subjects)
headache,
encephalopathy,
impairment,
At
3-month
follow-up,
still
20%
higher.
six-
9-month
there
tendency
headache
further
increase
prevalence.
decreased
but
remained
high
some
such
fatigue
anosmia/hyposmia.
Other
had
more
fluctuating
occurrence.
<b><i>Discussion:</i></b>
Neurological
prevalent
over
1-year
period,
overall
There
downward
trend
time,
suggesting
early
post-COVID-19
may
be
long-lasting
not
permanent.
However,
especially
point,
robust
are
needed
confirm
trend.
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(9), С. 5638 - 5638
Опубликована: Апрель 25, 2023
Post-acute
COVID-19
syndrome
is
frequently
observed
in
workers
and
has
a
substantial
impact
on
work
ability.
We
conducted
health
promotion
program
to
identify
cases
of
post-COVID
syndrome,
analyze
the
distribution
symptoms
their
association
with
Of
1422
who
underwent
routine
medical
examination
2021,
1378
agreed
participate.
Among
latter,
164
had
contracted
SARS-CoV-2
115
(70%
those
were
infected)
persistent
symptoms.
A
cluster
analysis
showed
that
most
characterized
by
sensory
disturbances
(anosmia
dysgeusia)
fatigue
(weakness,
fatigability,
tiredness).
In
one-fifth
these
cases,
additional
included
dyspnea,
tachycardia,
headache,
sleep
disturbances,
anxiety,
muscle
aches.
Workers
found
have
poorer
quality
sleep,
increased
fatigue,
depression,
decreased
ability
compared
whose
rapidly
disappeared.
It
important
for
occupational
physician
diagnose
workplace
since
this
condition
may
require
temporary
reduction
tasks
supportive
treatment.
Healthcare,
Год журнала:
2023,
Номер
11(2), С. 218 - 218
Опубликована: Янв. 11, 2023
Persistent
COVID-19
condition
includes
a
wide
variety
of
symptoms
and
health
problems
indeterminate
duration.
The
present
study
examined
the
sociodemographic
clinical
characteristics
population
with
Long
COVID
seen
in
Primary
Care
using
questionnaire
based
on
existing
scientific
literature.
It
was
an
observational
descriptive
Spanish
over
14
years
age.
responses
were
analysed
by
means
analysis
variables
recorded,
addition
to
bivariate
determine
existence
relationship
between
persistent
such
as
gender,
age,
vaccination
status
or
concomitant
pathology.
results
obtained
clearly
describe
population,
highlighting
predominance
female
gender
prevalence
tiredness
fatigue.
Furthermore,
relevant
information
differences
symptomatology
according
previous
pathologies
alterations
derived
from
infection
and/or
vaccination.
These
data
are
important
for
better
detection,
diagnosis
treatment
improvement
quality
life
this
population.
Zeitschrift für Neuropsychologie,
Год журнала:
2024,
Номер
35(2), С. 63 - 76
Опубликована: Май 1, 2024
Abstract:
This
review
assesses
neurocognitive
studies
on
long-/post-COVID-19
adult
patients,
highlighting
the
research
gaps.
We
categorize
populations
by
infection
severity,
demographics,
inclusion
of
controls,
and
psychological/biological
factors.
Methodologically,
we
analyzed
73
(95,600
subjects)
from
December
2019
to
October
2022
using
PRISMA-ScR
guidelines
PICO
framework.
Our
findings
revealed
that
most
lacked
control
groups
(88
%)
reported
unclear
overall
cognitive
outcomes
(73
%).
While
frequently
assessed
executive
functions
(86
attention
(85
%),
there
were
few
longitudinal
studies.
Varied
reporting
sample
sizes
further
complicated
analysis.
The
identified
gaps
encompass
convenience
sampling,
limited
studies,
inadequate
use
test
batteries,
leading
a
discrepancy
between
expected
outcomes.
absence
standardized
comparisons
inconsistent
statistical
methods
exacerbated
these
