Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Mitochondrial dysfunction plays a pivotal role in the development of age-related diseases, particularly neurodegenerative disorders. The etiology mitochondrial involves multitude factors that remain elusive. This review centers on elucidating role(s) excitotoxicity, oxytosis/ferroptosis and neurodegeneration within context bioenergetics, biogenesis, mitophagy oxidative stress explores their intricate interplay pathogenesis diseases. effective coordination turnover processes, notably is assumed to be critically important for cellular resilience longevity. However, age-associated decrease impedes elimination dysfunctional mitochondria, consequently impairing biogenesis. deleterious cascade results accumulation damaged mitochondria deterioration functions. Both excitotoxicity have been demonstrated contribute significantly pathophysiology including Alzheimer's disease (AD), Parkinson's (PD), Huntington's Disease (HD), Amyotrophic Lateral Sclerosis (ALS) Multiple (MS). Excitotoxicity, characterized by excessive glutamate signaling, initiates events involving calcium dysregulation, energy depletion, intricately linked dysfunction. Furthermore, emerging concepts surrounding underscore importance iron-dependent lipid peroxidation engagement neurodegeneration. not only discusses individual contributions ferroptosis but also emphasizes convergence with dysfunction, key driver Understanding crosstalk between oxytosis/ferroptosis, holds potential pave way mitochondrion-targeted therapeutic strategies. Such strategies, focus mitophagy, stress, emerge as promising avenues intervention.

Язык: Английский

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Metabolomics Reveals Nutritional Diversity among Six Coarse Cereals and Antioxidant Activity Analysis of Grain Sorghum and Sweet Sorghum

Antioxidants, Год журнала: 2022, Номер 11(10), С. 1984 - 1984

Опубликована: Окт. 5, 2022

Coarse cereals are rich in dietary fiber, B vitamins, minerals, secondary metabolites, and other bioactive components, which exert numerous health benefits. To better understand the diversity of metabolites different coarse cereals, we performed widely targeted metabolic profiling analyses six popular millet, coix, buckwheat, quinoa, oat, grain sorghum, 768 identified. Moreover, quinoa buckwheat showed significantly metabolomic profiles compared with cereals. Analysis accumulation patterns common nutritional among found that carbohydrates follows a conserved pattern while those amino acids, flavonoids, lipids were complementary. Furthermore, species-specific each cereal identified, neighbor-joining tree for was constructed based on metabolome data. Since sorghum contains more occupies unique position tree, metabolite differences between 654 sweet LTR108 finally specifically, revealing contained flavonoids had higher antioxidant activity than 654. Our work supports an overview understanding nutrient value provides evidence healthy diet. Additionally, superior clues its uses.

Язык: Английский

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Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress

Life, Год журнала: 2023, Номер 13(4), С. 1019 - 1019

Опубликована: Апрель 15, 2023

Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a mechanism neurodegeneration, and release L-Glu after stroke onset leads to toxicity cascade that results in neuronal death. The acai berry (Euterpe oleracea) is potential dietary nutraceutical. aim this research was investigate neuroprotective effects aqueous ethanolic extracts reduce neurotoxicity cells triggered by application. on cell viability were quantified using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) lactate dehydrogenase (LDH) assays, cellular bioenergetics assessed via quantitation levels ATP, mitochondrial membrane (MMP), production reactive oxygen species (ROS) neuroblastoma cells. Cell also evaluated human cortical progenitor culture or/and In isolated cells, activated currents patch-clamping employed determine whether mediated ionotropic L-Glu-receptors (iGluRs). caused significant reduction viability, MMP increased ROS production. co-application both with provided neuroprotection against sustained decreased LDH production, restored ATP levels, reduced levels. Whole-cell patch-clamp recordings showed not activation iGluRs Fractionation analysis liquid chromatography-mass spectrometry identified several phytochemical antioxidants may have effects. summary, contains nutraceuticals antioxidant activity be beneficial component limit pathological deficits excessive accumulations.

Язык: Английский

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Creatine Activity as a Neuromodulator in the Central Nervous System

Archives of Razi Institute, Год журнала: 2023, Номер unknown, С. 1169 - 1175

Опубликована: Июль 24, 2023

Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated similar to neurotransmitters, creatine released in an excitotoxic action potential-dependent manner acts as neuromodulator. deficiency syndromes are characterized by severe mental developmental disorders. Studies have reported brain content could be enhanced with supplementation. Nevertheless, there still limited knowledge about the effects of on central nervous system. However, ample proved neuroprotective various aspects, such cognition, memory skills, spatial memory. The present review aimed available experimental data clinical observations confirming roles transmission process. A systematic search literature was performed PubMed, Scopus, Embase, Cochrane Library, Web Science, Google Scholar database using all MeSH terms for Creatine, Phosphocreatine, Bioenergetics, Nervous system, Brain, Cognition, Neuroprotection. Electronic searches were combined duplicates removed. Here, first, its potential influence health performance briefly reviewed. Next, existing specifically explored understand how interact neurotransmitter revealed exogenous supplementation decreases neuronal cell loss paradigms neurological diseases. It observed N-methyl-D-aspartate receptor, Na+-K+-ATPase enzyme, GABAA serotonin 1A receptors, presumably α1-adrenoceptor play critical process which implies can considered

Язык: Английский

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Treatment with N-acetylcysteine and/or zinc sulfate restores neurobehavioral functions through modulation of neurochemical activities in mice exposed to bonny light crude oil

Nutrire, Год журнала: 2024, Номер 49(1)

Опубликована: Янв. 8, 2024

Язык: Английский

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