Polysaccharides extracted from Polygonatum sibiricum alleviate intestine-liver-kidney axis injury induced by citrinin and alcohol co-exposure in mice

Food and Chemical Toxicology, Год журнала: 2025, Номер 197, С. 115314 - 115314

Опубликована: Фев. 7, 2025

Язык: Английский

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Animal models to study cognitive impairment of chronic kidney disease

AJP Renal Physiology, Год журнала: 2024, Номер 326(6), С. F894 - F916

Опубликована: Апрель 18, 2024

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases progressive loss of function. MCI characterized by a decline performance greater than expected for an individual age education level but minimal instrumental activities daily living. Deterioration can affect one or several domains (attention, memory, executive functions, language, perceptual motor social cognition). Given the increasing disease, more CKD will also develop causing enormous burden these individuals, their relatives, society. However, underlying pathomechanisms are poorly understood, current therapies mostly aim at supporting patients lives. This illustrates urgent need to elucidate pathogenesis potential therapeutic targets test novel appropriate preclinical models. Here, we outline necessary criteria experimental modeling disorders CKD. We discuss use mice, rats, zebrafish as model systems present valuable techniques through which function be assessed this setting. Our objective enable researchers overcome hurdles accelerate research aimed improving therapy MCI.

Язык: Английский

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Uremic toxins and the brain in chronic kidney disease

Journal of Nephrology, Год журнала: 2024, Номер 37(5), С. 1391 - 1395

Опубликована: Апрель 16, 2024

Язык: Английский

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Rezeption und Bewertung internistischer Befunde

Springer eBooks, Год журнала: 2025, Номер unknown, С. 553 - 564

Опубликована: Янв. 1, 2025

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Effects of Sildenafil on the Recovery of Cognitive Function and the Protection of Neuronal Cell Death Following Transient Global Cerebral Ischemia in Gerbils

Опубликована: Май 21, 2024

Cerebral ischemic stroke poses a significant global cause of death, with ischemia-reperfusion injury contributing to neuronal cell death and tissue damage. However, therapeutic approaches meaningful treatment effects for patients in actual clinical practice are lacking. This study investigated the potential neuroprotective sildenafil, phosphodiesterase-5 inhibitor, cerebral ischemia model. We explored impact sildenafil on GFAP AQP-4 expression, which markers associated astrocyte activation water homeostasis, respectively. The immunofluorescence analysis revealed that number cells co-expressing markers, increased ischemia-induced group, was significantly reduced sildenafil-treated groups, suggesting mitigating effect activation. Additionally, we conducted diverse behavioral tests, including open-field test, novel object recognition, Barnes maze, Y-maze, passive avoidance assess cognitive function impaired by ischemia. Cognitive improvements were observed following administration (20mg/kg) compared untreated group. Taken together, results presented here suggest sildenafil's as agent alleviating delayed

Язык: Английский

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Indoxyl sulfate induces apoptotic cell death by inhibiting glycolysis in human astrocytes

Kidney Research and Clinical Practice, Год журнала: 2023, Номер 43(6), С. 774 - 784

Опубликована: Авг. 10, 2023

Background: Neurologic complications, such as cognitive and emotional dysfunction, have frequently been observed in chronic kidney disease (CKD) patients. Previous research shows that uremic toxins play a role the pathogenesis of CKD-associated impairment. Since astrocytes contribute to protection survival neurons, astrocyte function brain metabolism may neurodegeneration. Indoxyl sulfate (IS) is most popular toxin. However, how IS-induced injury brings about neurologic complications CKD patients has not elucidated. Methods: The rate extracellular acidification was measured when IS (0.5–3 mM, 4 or 7 days) treatment applied. hexokinase 1 (HK1), pyruvate kinase isozyme M2 (PKM2), dehydrogenase (PDH), phosphofructokinase (PFKP) protein levels were also measured. activation apoptotic pathway investigated using confocal microscope, fluorescence- activated cell sorting, three-dimensional imaging used. Results: In astrocytes, affected glycolysis only dose-dependently but time-dependently. Additionally, HK1, PKM2, PDH, PFKP decreased IS-treated group compared control. results prominent cases with higher doses longer exposure duration. features after observed. Conclusion: Our showed inhibition by leads death via apoptosis. Specifically, longterm higher-dose exposures had more serious effects on astrocytes. suggest related targets could provide novel approach dysfunction

Язык: Английский

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Effects of Sildenafil on Cognitive Function Recovery and Neuronal Cell Death Protection after Transient Global Cerebral Ischemia in Gerbils

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2077 - 2077

Опубликована: Сен. 12, 2024

Cerebral ischemic stroke is a major cause of death worldwide due to brain cell resulting from ischemia-reperfusion injury. However, effective treatment approaches for patients with are still lacking in clinical practice. This study investigated the potential neuroprotective effects sildenafil, phosphodiesterase-5 inhibitor, gerbil model global ischemia. We sildenafil on expression glial fibrillary acidic protein and aquaporin-4, which markers related astrocyte activation water homeostasis, respectively. Immunofluorescence analysis showed that number cells co-expressing these markers, was elevated ischemia-induced group, significantly reduced sildenafil-treated groups. suggests may have mitigating effect induced by Additionally, we performed various behavioral tests, including open-field test, novel object recognition, Barnes maze, Y-maze, passive avoidance evaluate sildenafil's cognitive function impaired Overall, results suggest serve as agent, potentially alleviating delayed neuronal improving

Язык: Английский

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Possible protective effect of zinc administration on renal and cognitive changes occurring in uninephrectomized adult male Wistar rats

Experimental Physiology, Год журнала: 2022, Номер 108(2), С. 253 - 267

Опубликована: Ноя. 24, 2022

What is the central question of this study? Are renal changes occurring post-nephrectomy accompanied by cognitive changes, and does early administration zinc supplements such as ZnSO

Язык: Английский

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AST-120 Protects Cognitive and Emotional Impairment in Chronic Kidney Disease Induced by 5/6 Nephrectomy

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1043 - 1043

Опубликована: Окт. 22, 2024

Uremic toxins resulting from chronic kidney disease (CKD) can cause cognitive and emotional disorders, as well cardiovascular diseases. Indoxyl sulfate (IS) p-cresol are notable uremic found in patients with CKD. However, few studies have investigated whether reducing alleviate disorders associated

Язык: Английский

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Activation of mGluR2/3 by LY379268 alleviates PTSD fear memories by down-regulating the CaMKII/CREB signaling pathway in the amygdala

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Background People with post-traumatic stress disorder (PTSD) have recurrent memory flashbacks of traumatic events, leading to severe symptoms anxiety and even phobias. Targeted drug staging interventions may eliminate or alleviate fear memory. The metabotropic glutamate receptor II (mGluR2/3) agonist LY379268 has been shown reverse deficits; however, whether it can treat in PTSD during the consolidation period remains unclear. Methods Single prolonged contextual conditioning (SPS&CFC) rat models were established. was administered at varying concentrations (2, 6, 12 µM) into lateral ventricles PTSD-like assessed using open-field, elevated plus-maze, freezing behavior tests. Western blotting immunofluorescence analyses conducted determine phosphorylated levels Ca²⁺/calmodulin-dependent protein kinase (P-CaMKII), extracellular signal-regulated (P-ERK), cyclic-AMP responsive element binding (P-CREB) proteins amygdala (AMY) region. Transmission electron microscopy used observe synaptic ultrastructure changes AMY. Results Rats SPS&CFC group had increased P-CaMKII, P-ERK, P-CREB damaged morphology Following injection 6 µM LY379268, improved exploration freeze behaviors, reduced AMY, remodeling observed. Administration behaviors autonomous rats. Conclusion administration reduce rats by regulating CaMKII/CREB signaling pathway via mGluR2/3 activation within Our results provide a promising target for alleviating phase.

Язык: Английский

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