The effects of long-term high-altitude exposure on cognition: A meta-analysis

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105682 - 105682

Опубликована: Апрель 19, 2024

Язык: Английский

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Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Сен. 4, 2023

Hypobaric hypoxia (HH) characteristics induce impaired cognitive function, reduced concentration, and memory. In recent years, an increasing number of people have migrated to high-altitude areas for work study. Headache, sleep disturbance, impairment from HH, severely challenges the physical mental health affects their quality life efficiency. This review summarizes manifestations, mechanisms, preventive therapeutic methods HH environment affecting function provides theoretical references exploring treating high altitude-induced impairment.

Язык: Английский

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A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders

The Journal of Physiology, Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Abstract Periodic breathing during sleep at high altitude is almost universal among sojourners. Here, in the context of acclimatization and adaptation, we provide a contemporary review on periodic altitude, explore whether this an adaptive or maladaptive process. The mechanism(s), prevalence role acclimatized lowlanders are contrasted with available data from adapted indigenous populations (e.g. Andean Tibetan highlanders). It concluded that (1) persists severity proportional to sleeping altitude; (2) does not seem coalesce poor quality such that, acclimatization, there appears be lengthening cycle length minimal impact average oxygen saturation; (3) highlanders appear demonstrate blunting breathing, compared lowlanders, comprising feature withstands negative influences chronic mountain sickness. These observations indicate no obvious consequences; however, attenuated adaptation therefore potentially reflects trait environment. image

Язык: Английский

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Ferroptosis pathways: Unveiling the neuroprotective power of cistache deserticola phenylethanoid glycosides

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118465 - 118465

Опубликована: Июнь 27, 2024

Cistanche deserticola is a kind of parasitic plant living in the roots desert trees. It rare Chinese medicine, which has effect tonifying kidney Yang, benefiting essence and blood moistening intestinal tract. Cistache phenylethanoid glycoside (PGS), an active component found Ma, have potential tonifying, intellectual enhancing, neuroprotective effects. total capsule been marketed to treat vascular dementia disease. To identify renal, enhancing effects PGS explore exact targets mechanisms PGS. This study systematically investigated four types pathways leading ferroptosis through transcriptome, metabolome, ultrastructure molecular biology techniques explored mechanism by multiple synergistically exert on hypoxia. alleviated learning memory dysfunction pathological injury mice exposed hypobaric hypoxia attenuating hypoxia-induced hippocampal histopathological damage, impairing blood‒brain barrier integrity, increasing oxidative stress levels, expression cognitive proteins. reduced formation lipid peroxides improved upregulating GPX-4/SCL7A311 axis downregulating ACSL4/LPCAT3/LOX axis. also facilitating cellular Fe2+ efflux regulating mitochondrial transport effectively antagonized cell induced erastin (a inducer). demonstrated prevents hypoxic nerve pathways, achieved mice. provides theoretical basis for development application

Язык: Английский

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Cognitive performance during exposure to moderate normobaric hypoxia after sleep restriction: Relationship to physiological and stress biomarkers

Physiology & Behavior, Год журнала: 2024, Номер 287, С. 114666 - 114666

Опубликована: Авг. 30, 2024

Язык: Английский

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Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure

Graefe s Archive for Clinical and Experimental Ophthalmology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

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Neurologische und psychiatrische Notfälle im Gebirge

Springer eBooks, Год журнала: 2025, Номер unknown, С. 341 - 365

Опубликована: Янв. 1, 2025

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Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia

Pharmaceuticals, Год журнала: 2025, Номер 18(5), С. 738 - 738

Опубликована: Май 17, 2025

Background/Objectives: High-altitude environments have a significant detrimental impact on the cognitive functions of brain. Qi Jing Wan (QJW), traditional herbal formula composed Angelica sinensis, Astragalus membranaceus, and Rhizoma Polygonati Odorati, has demonstrated potential efficacy in treating disorders. However, its effects dysfunction plateau hypoxic remain unclear. Methods: In this study, acute chronic impairment mouse models were constructed to investigate preventive therapeutic QJW active ingredient, diosgenin (Dio). Behavioral experiments conducted assess learning memory mice. Morphological changes hippocampal neurons synapses assessed, microglial activation inflammatory factor levels measured evaluate brain damage. Potential ingredients capable crossing blood–brain barrier identified through chemical composition analysis network database screening, followed by validation animal organoid experiments. Transcriptomics analysis, immunofluorescence staining, molecular docking techniques employed explore underlying mechanisms. Results: significantly enhanced abilities model mice, reduced structural damage neurons, restored NeuN expression, inhibited activation, improved synaptic revealed that Dio alleviated protected function regulating expression PDE4C. Conclusions: These findings indicate ingredient effectively mitigate injury prevent high-altitude environments.

Язык: Английский

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The effects of sleep deprivation, acute hypoxia, and exercise on cognitive performance: A multi-experiment combined stressors study

Physiology & Behavior, Год журнала: 2023, Номер 274, С. 114409 - 114409

Опубликована: Ноя. 16, 2023

Both sleep deprivation and hypoxia have been shown to impair executive function. Conversely, moderate intensity exercise is known improve In a multi-experiment study, we tested the hypotheses that would ameliorate any decline in function after i) three consecutive nights of partial (PSD) (Experiment 1) ii) isolated combined effects single night total (TSD) acute 2). Using rigorous randomised controlled crossover design, 12 healthy participants volunteered each experiment (24 total, 5 females). both experiments seven (2-choice reaction time, logical relations, manikin, mathematical processing, 1-back, 2-back, 3-back) tasks were completed at rest during 20-min semi-recumbent, cycling. Tasks following conditions: before PSD habitual normoxia (FIO2 = 0.12) one TSD Although on functions inconsistent, (regardless hypoxic status) reduced functions. Significantly, regardless or status, are improved an bout exercise. These novel data indicate improves performance TSD, status. The key determinants and/or mechanism(s) responsible for this improvement still need be elucidated. Future work should seek identify these mechanisms translate significant findings into occupational skilled settings.

Язык: Английский

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High altitude adaptation, common high-altitude disorders and the effects of high altitude on mental health

Sports Psychiatry, Год журнала: 2024, Номер 3(4), С. 197 - 208

Опубликована: Ноя. 1, 2024

Abstract: Introduction: The human brain is a highly oxygen-dependent organ. Low environmental oxygen availability (e.g., hypobaric hypoxia at altitude) major challenge to the and numerous endogenous cellular systemic responses therefore are in place mitigate hypoxic stress. When dose of stress surpasses adaptive capabilities brain, cerebral forms high-altitude illnesses can develop, prevalence which increases with altitude. Hypoxia also trigger psychotic symptoms. Despite that, effects altitude exposures on people pre-existing mental disorders surprisingly scarcely investigated. Methods: In this narrative review we summarize literature brain’s put them context somatic consequences exposure from an interdisciplinary perspective. Results: We identify knowledge gaps high clinical relevance related safety exposures, particularly for individuals disorders. Conclusions: Taken together, research into vulnerability neuropsychiatric risk developing symptoms different populations (diseased, healthy, athletes) urgently needed provide appropriate evidence-based counselling treatment.

Язык: Английский

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