Adolescent stress induces behavioral changes and hippocampal excitatory/inhibitory imbalance: involvement of redox dysregulation and mitochondrial dysfunction DOI Creative Commons

Thamyris Santos Silva

Опубликована: Авг. 2, 2023

The developing adolescent brain is highly susceptible to social experiences and environmental insults, influencing how personality traits emerge.We previously found that stress leads long-lasting behavioral changes excitatory/inhibitory (E/I) balance dysregulation in the ventral hippocampus (vHip) associated with neurodevelopmental disorders, such as schizophrenia bipolar disorder.The neurobiological mechanisms of psychiatric disorders have been linked oxidative damage reduced antioxidant capacity brain.However, impact severe stressors during adolescence, a critical period, on mitochondrial function, redox balance, their functional consequences are not completely understood.We hypothesized respiratory function homeostasis vHip affected by stress, leading electrophysiological neuropsychiatric disorders.First, we performed characterization late adolescence (postnatal day, PND 47 -50), including naïve animals exposed from 31 until 40 (10 days footshock 3 restraint sessions) assessing sociability (social interaction test) cognition (novel-object recognition test).Then, uncovered E/I analyzing activity glutamate pyramidal neurons, number parvalbumin (PV)-containing GABAergic interneurons possible association stress.To address dynamic homeostasis, high-resolution respirometry, DHE staining, MitoSox™ AmplexRed ® assays one (PND 41) ten 51) after protocol.Also, evaluated glutathione (GSH) disulfide (GSSG) levels at 51.Finally, assess genome-wide transcriptomic signature stressed performing bulk RNAsequencing following tests.One week adolescent-stressed exhibited: (1) loss cognitive impairment; (2) enhanced neuron activity; (3) reduction PV-positive cells perineuronal nets.These were an increased marker vHip, which was co-localized PV interneurons.By respirometry analysis, impacted uncoupled efficiency phosphorylation 51).In addition, displayed revealed molecular analysis.GSSG serum negatively correlated performance, indicating GSH oxidized ROS conditions, may affect phenotype.In another cohort animals, identified three cluster subgroups principal component analysis assessment: higher-behavioral z-score (HBZ), lower-behavioral (LBZ), animals.Genes encoding subunits complexes significantly down-regulated both LBZ (Cox7c) (Coa5), while Txnip gene encoded thioredoxin-interacting protein up-regulated performance.Our results identify genes distinct phenotypes highlight negative regulation, partially imbalance abnormalities.

Язык: Английский

Response of Cellular Stress Toward the Hormetic Phytochemicals in Brain Aging DOI
Aloke Saha, Tanmay Sanyal, Pronoy Mukherjee

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2
Are Advanced Oxidation Protein Products (AOPPs) Levels Altered in Neuropsychiatric Disorders? An Integrative Review DOI

Gerson Fernandes de Brum,

Guilherme Vargas Bochi

Molecular Neurobiology, Год журнала: 2024, Номер 61(11), С. 9043 - 9059

Опубликована: Апрель 6, 2024

Язык: Английский

Процитировано

1
Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia DOI
Risako Fujikawa, Jun Yamada,

Shoichiro Maeda

и другие.

Journal of Neurochemistry, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Recent studies have highlighted the potential involvement of reactive oxygen species (ROS) and microglia, a major source ROS, in pathophysiology schizophrenia. In our study, we explored how second-generation antipsychotic risperidone (RIS) affects ROS regulation microglial activation hippocampus using mouse ketamine (KET) model KET administration resulted schizophrenia-like behaviors male C57BL/6J mice, such as impaired prepulse inhibition (PPI) acoustic startle response hyper-locomotion. These were mitigated by RIS. We found that gene expression level an enzyme responsible for production (Nox2), which is primarily associated with activated was lower KET/RIS-treated mice than KET-treated mice. Conversely, levels antioxidant enzymes (Ho-1 Gclc) higher The density increased counteracted Hierarchical cluster analysis revealed three morphological subtypes microglia. control most microglia resting-ramified (type I, 89.7%). shifted composition to moderately ramified II, 44.4%) hyper-ramified III, 25.0%). type II decreased 32.0%, while III 34.0%. An vitro assay showed dissociated hippocampal this effect Furthermore, discovered NOX2 inhibitor could counteract KET-induced behavioral deficits. findings suggest pharmacological RIS may play crucial role ameliorating schizophrenia-related symptoms. Moreover, modulating regulate has emerged novel avenue developing innovative treatments

Язык: Английский

Процитировано

1
Elevated levels of oxLDL and LOX-1: Implications for schizophrenia pathophysiology DOI
Merve Akkuş, Hatice Solak

Journal of Psychiatric Research, Год журнала: 2024, Номер 177, С. 140 - 146

Опубликована: Июль 11, 2024

Язык: Английский

Процитировано

1
Pro/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid DOI Creative Commons
Joanna Róg,

Łukasz Łobejko,

Michalina Hordejuk

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Сен. 11, 2024

Disturbances in pro/antioxidant balance emerge as a crucial element bipolar disorder (BD). Some studies suggest that treatment effects on trace concentration BD. This study aimed to identify (a) the changes related oxidative stress BD and their relationship with elements engaged homeostasis; (b) biomarkers using machine learning algorithm classification regression tree (C&RT) analysis. 62 individuals 40 healthy (HC) were included study. The of state selenium, zinc, arsenic blood assessed. We found higher total antioxidant capacity, catalase, advanced oxidation protein products lower 4-hydroxynonenal (4-HNE), glutathione, glutathione peroxidase (GPx) compared HC. All examined group A combination two variables, 4-HNE (cut-off: ≤ 0.004 uM/mg protein) GPx 0.485 U/mg protein), was most promising markers for separating from area under receiver operating characteristic curve values C&RT 90.5%. patients may be target new therapeutic or diagnostic opportunity biomarkers.

Язык: Английский

Процитировано

1
Circulating Cell-Free Mitochondrial DNA in Plasma of Individuals with Schizophrenia and Cognitive Deficit in Mexican Population DOI Creative Commons
Dulce Dajheanne García-de la Cruz, Isela Esther Juárez‐Rojop, Carlos Alfonso Tovilla‐Zárate

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 1757 - 1765

Опубликована: Сен. 1, 2024

Cognitive domains are affected in patients with schizophrenia. Mitochondrial dysfunction has been proposed as a possible origin of these symptoms. Cell-free mitochondrial DNA (cf-mtDNA) is an indicator cellular stress, and it can be identified individuals age-associated disorders, this study aimed to explore the presence cf-mtDNA plasma schizophrenia its association cognitive deficit.

Язык: Английский

Процитировано

1
Kynurenine pathway dysregulation as a mechanistic link between cognitive impairment and brain damage: Implications for multiple sclerosis DOI Creative Commons
Marie Kupjetz, Tiffany Y. Wences Chirino, Niklas Joisten

и другие.

Brain Research, Год журнала: 2024, Номер unknown, С. 149415 - 149415

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Thiol-disulphide Homeostasis in Patients with Schizophrenia: The Potential Biomarkers of Oxidative Stress in Acute Exacerbation of Schizophrenia DOI Open Access
Şükrü Alperen Korkmaz, Semra Ulusoy Kaymak, Salim Neşeli̇oğlu

и другие.

Clinical Psychopharmacology and Neuroscience, Год журнала: 2023, Номер 22(1), С. 139 - 150

Опубликована: Авг. 2, 2023

: Recent evidence suggests that oxidative stress contributes to the pathophysiology of schizophrenia. This study aimed compare thiol-disulphide homeostasis in acute and stable phases schizophrenia for first time.

Язык: Английский

Процитировано

3
Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia DOI Open Access
Florian W. Adraoui, Linda Douw, Gerard J.M. Martens

и другие.

Опубликована: Янв. 24, 2023

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world’spopulation. Social-cognitive impairments in SZ prevent positive social interactions and lead toprogressive withdrawal. The neurobiological underpinnings social-cognitive symptomsremain poorly understood, which hinders development novel treatments. At wholebrainlevel, an abnormal activation brain regions interregional dysconnectivity withinsocial-cognitive networks have been identified as major contributors to these symptoms. Atthe cellular subcellular levels, interplay between oxidative stress, neuroinflammation andN-methyl-D-aspartate receptor hypofunction thought underly pathology. However, it notclear how molecular processes are linked with genesisof Here, we aim bridge gap macroscale (connectivityanalyses) microscale (molecular mechanistic) knowledge by proposing impairedmyelination disinhibition local microcircuits possible causative biological pathwaysleading activity brain. Furthermore, recommendelectroencephalography promising translational technique that can foster pre-clinical drugdevelopment discuss attractive drug targets for treatment symptoms SZ.

Язык: Английский

Процитировано

2
Ketogenic diets in clinical psychology: examining the evidence and implications for practice DOI Creative Commons
Nicole Laurent,

Erin L. Bellamy,

Donika Hristova

и другие.

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Сен. 26, 2024

Introduction The application of ketogenic dietary interventions to mental health treatments is increasingly acknowledged within medical and psychiatric fields, yet its exploration in clinical psychology remains limited. This article discusses the potential implications diets, traditionally utilized for neurological disorders, broader practices. Methods presents a perspective based on existing diet research historical use, biological mechanisms, therapeutic benefits. It examines these diets treatment their relevance practice. Results review informs psychologists benefits introduces literature underlying mechanisms involved, such as modulation neurotransmitters, reduction inflammation, stabilization brain energy metabolism, demonstrating biopsychosocial practice psychology. Conclusion By considering metabolic therapies, can broaden scope integration provides care model that incorporates knowledge option care. emphasizes need further training support effective implementation this psychiatry intervention.

Язык: Английский

Процитировано

0