Organophospate-Induced Pathology: Mechanisms of Development, Principles of Therapy and Features of Experimental Studies DOI
Н. В. Гончаров, Daria A. Belinskaia, П. В. Авдонин

и другие.

Российский физиологический журнал им  И  М  Сеченова, Год журнала: 2023, Номер 109(10), С. 1349 - 1397

Опубликована: Окт. 1, 2023

Organophosphates (OP) are one of the most common neurotoxic xenobiotics. In acute OP poisoning, as a result suppression synaptic acetylcholinesterase (AChE) activity, cholinergic syndrome develops, which can transform into status epilepticus. Within few days after so-called an intermediate develop, is associated with prolonged inhibition AChE, desensitization nicotinic receptors, and functional degradation synapses muscle fibers. 10–20 single or repeated subacute OP-induced delayed polyneuropathy (OPIDN) develop – neurodegenerative disease, signs ataxia, loss function distal sensory motor axons peripheral nerves. The occurrence neuropsychiatric disorder (NPD) caused by chronic exposure to relatively low-toxicity organophosphorus compounds usually not poisoning; symptoms include cognitive impairment, fatigue, extrapyramidal symptoms. list possible diseases pathological conditions (syndromes) that acute, effects on human body has expanded in recent years due number known (Alzheimer’s, Parkinson’s, multiple sclerosis, etc.). aging general brain particular considered review from point view consequences serve nonspecific trigger related diseases. Gulf consequence intoxication, but also interest context pathology, since its etiology pathogenesis cholinesterase inhibitors. presents data indicating important role vascular endothelium development pathology; first suggestions were made clinicians late 1980s, experimental obtained early 2000s. principles therapy for poisoning outlined, taking account years. Some methods studying experiments vitro, ex vivo laboratory animals, including use carboxylesterase inhibitors, presented. part investigations been remains search new biomarkers assess effectiveness adjuvant regenerative therapies.

Язык: Английский

Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies DOI Creative Commons
Hajime Koyama, Teru Kamogashira, Tatsuya Yamasoba

и другие.

Antioxidants, Год журнала: 2024, Номер 13(1), С. 76 - 76

Опубликована: Янв. 5, 2024

Heavy metals are often found in soil and can contaminate drinking water, posing a serious threat to human health. Molecular pathways curation therapies for mitigating heavy metal toxicity have been studied long time. Recent studies on oxidative stress aging shown that the molecular foundation of cellular damage caused by metals, namely, apoptosis, endoplasmic reticulum stress, mitochondrial share same as those involved senescence aging. In recent studies, many types exposures used both animal models. Chelation therapy is traditional treatment toxicity. However, recently, various antioxidants be effective treating metal-induced damage, shifting research focus investigating interplay between metals. this review, we introduce basis its relationship with aging, summarize clinical implications, discuss other agents protective effects against damage.

Язык: Английский

Процитировано

31
Employing a Toxic Aging Coin approach to assess hexavalent chromium (Cr[VI])-induced neurotoxic effects on behavior: Heads for age differences DOI

Samuel T. Vielee,

Jessica Isibor,

William J. Buchanan

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 489, С. 117007 - 117007

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

5
Heavy Metals in Umbilical Cord Blood: Effects on Epigenetics and Child Development DOI Creative Commons
Sudipta Dutta, Douglas M. Ruden

Cells, Год журнала: 2024, Номер 13(21), С. 1775 - 1775

Опубликована: Окт. 26, 2024

Heavy metals like arsenic, mercury, cadmium, and lead are harmful pollutants that can change how our genes regulated without altering the DNA sequence, specifically through a process called methylation (DNAm) at 5-methylcytosine, an epigenetic mark we will focus on in this review. These changes DNAm most sensitive during pregnancy, critical time for development when these modifications affect traits expressed. Historically, research environmental effects has focused adults, but now there is more emphasis studying impacts early childhood. The placenta acts as protective barrier between mother baby, by examining it, scientists identify key might long-term health. This review looks exposure to heavy pregnancy cause gene regulation newborns, seen their umbilical cord blood. reflect baby’s genetic state be influenced mother’s environment genetics, well own genetics.

Язык: Английский

Процитировано

4
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

и другие.

F1000Research, Год журнала: 2025, Номер 14, С. 134 - 134

Опубликована: Янв. 27, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Язык: Английский

Процитировано

0
Health effects of mixed metal exposure on accelerating aging among the elderly population DOI Creative Commons

Chuanli Yang,

Jijun Zhang, Haohan Liu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117760 - 117760

Опубликована: Фев. 1, 2025

Human exposure to heavy metals occurs through multiple pathways in daily life. However, the effects of mixed metal on accelerated aging elderly U.S. population remains unclear. This study aims investigate association between concentrations blood and urine onset aging. A total 2530 individuals were included analysis 716 this study. GrimAge acceleration (AgeAccelGrim) was calculated as residuals from regressing DNA methylation chronological age. Weighted multivariable logistic regression models applied analyze relationship with AgeAccelGrim. Bayesian kernel machine (BKMR) performed estimate individual or mixtures We found that cadmium (Cd) concentration positively associated an increased risk AgeAccelGrim both females males, odds ratios (OR) 5.73 (95 % confidence interval CI): 1.88-17.41, P trend = 0.008) 14.25 CI: 4.88-41.62, < 0.001), respectively. Moreover, these associations more pronounced for urinary Cd compared Cd. Blood lead (Pb) also a 3.52-fold 1.21-10.24, 0.007) increase among males. BKMR confirmed aforementioned findings, identifying most significant contributor Exposure metals, either individually mixture, biological These

Язык: Английский

Процитировано

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

и другие.

F1000Research, Год журнала: 2025, Номер 14, С. 134 - 134

Опубликована: Фев. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Язык: Английский

Процитировано

0
Female Rat Behavior Effects from Low Levels of Hexavalent Chromium (Cr[VI]) in Drinking Water Evaluated with a Toxic Aging Coin Approach DOI Creative Commons

Samuel T. Vielee,

Jessica Isibor,

William J. Buchanan

и другие.

Applied Sciences, Год журнала: 2024, Номер 14(14), С. 6206 - 6206

Опубликована: Июль 17, 2024

We are facing a critical aging crisis, with geriatric populations (65+) growing to unprecedented proportions and ~4 million people (a 6.5-fold increase) expected become centenarians by 2050. This is compounded environmental pollution, which affects individuals of all ages contributes age-related diseases. As we have limited understanding how pollutants affect older distinctly from younger populations, these longer-lived present key knowledge gap. To address this gap, employ “Toxic Aging Coin” approach: heads consider age impacts chemical toxicity, tails chemicals act as gerontogens—or they accelerate biological aging. employed approach investigate hexavalent chromium (Cr[VI]) on female rats exposed 0.05 or 0.1 mg Cr(VI)/L in drinking water for 90 days; the maximum contaminant levels (i.e., highest permitted) World Health Organization U.S. Environmental Protection Agency, respectively. During exposure, performed battery behavior assays assess grip strength, locomotor coordination, anxiety, spatial memory, sociability, social novelty preference. observed differences Cr(VI) neurotoxicity, function, memory middle-aged females being particularly affected. further compared results males, noting many sex differences, especially rats. These data emphasize need variables toxicology revisit regulations Cr(VI).

Язык: Английский

Процитировано

2
Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions DOI

O. V. Kosmachevskaya,

Н. Н. Новикова, S. N. Yakunin

и другие.

Biochemistry (Moscow), Год журнала: 2024, Номер 89(S1), С. S180 - S204

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1
Gerontogen as the Toxicology of Aging<strong> </strong> DOI Open Access
Rahma Rahma, Agian Jeffilano Barinda

Опубликована: Апрель 10, 2024

Aging causes various degenerative diseases in the older adult population. Senescence, a state of permanent cell-cycle arrest accompanied by production pro-inflammatory factors known as senescence-associated secretory phenotype (SASP), is considered significant contributor to aging process and its chronic diseases. Ample evidence showed that stressors could induce senescence, including DNA damage, telomere shortening activation oncogenes, mitochondrial dysfunction. Numerous credible findings indicate environmental agents can UV radiation, high-fat diet, heavy metal exposure, cigarette smoke. These posed possibility many more may senescence accelerate but remain unidentified. Senescence also becomes intriguing due promising future pharmacological target blunt detrimental effects prevent aging-related diseases, either eliminating senescent cells or controlling SASP. On other hand, investigating has become intricate need for multi-marker approach translation vivo analysis. This review will discuss biomarkers, how identify gerontogens vivo, development senotherapy targets cells.

Язык: Английский

Процитировано

1
Mitigating Metal/Metalloid Stress in Crops: Strategies for Sustainable Agricultural Resilience DOI Creative Commons
Hany M. Almotairy

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 22, 2024

In the face of escalating soil contamination, this chapter meticulously examines multifaceted strategies employed to mitigate metal/metalloid stress in crops, an imperative endeavor for maintaining agricultural productivity and ensuring food security. Central discussion is exploring advanced phytoremediation techniques alongside strategic use amendments, highlighting their efficacy decontaminating metal/metalloid-laden soils. The narrative further extends crucial role mycorrhizal fungi enhancing plant resilience against toxicity innovative application genetic engineering breeding aimed at cultivating metal/metalloid-tolerant crop varieties. Moreover, sheds light on integrating cutting-edge remediation technologies, including electrokinetic nanotechnology, showcasing potential revolutionize conventional practices. synthesis these underscores importance adopting interdisciplinary approach, blending traditional methods with technological innovations develop sustainable effective solutions agriculture. Additionally, emphasizes need robust policy frameworks sophisticated monitoring tools manage health comprehensively, advocating a holistic strategy safeguard landscapes contamination.

Язык: Английский

Процитировано

1