Perspective Chapter: Monocytes on the Interface of Metabolic Disorders and Colorectal Cancer DOI Creative Commons
Elena Kazakova, Irina Larionova, Tatiana Sudarskikh

и другие.

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Colorectal cancer (CRC) is a prevalent malignancy with high incidence and mortality rates worldwide. Metabolic disorders, such as obesity, dyslipidemia, hyperglycemia, hypertension, have been identified significant risk factors contributing to the development progression of CRC. These metabolic conditions often result in low-grade inflammation, which plays crucial role tumor initiation progression. Monocytes, differentiate into tumor-associated macrophages (TAMs) within microenvironment (TME), are pivotal mediating these inflammatory responses. Monocytes individuals disorders exhibit altered phenotypes functions, enhancing their pro-inflammatory tumor-promoting activities. Our review describes intricate links between CRC on level circulating monocytes, highlighting how can drive aggravate via programming immunity. Various monocyte subsets, phenotypic changes, impact elucidated, providing insights potential therapeutic targets for prevention treatment. Understanding interplay alterations monocytes-derived TAMs TME essential developing effective strategies against

Язык: Английский

Metronomic Photodynamic Therapy with Conjugated Polymer Nanoparticles in Glioblastoma Tumor Microenvironment DOI Creative Commons
Matías Daniel Caverzán,

Paula Martina Oliveda,

Lucía Beaugé

и другие.

Cells, Год журнала: 2023, Номер 12(11), С. 1541 - 1541

Опубликована: Июнь 4, 2023

Alternative therapies such as photodynamic therapy (PDT) that combine light, oxygen and photosensitizers (PSs) have been proposed for glioblastoma (GBM) management to overcome conventional treatment issues. An important disadvantage of PDT using a high light irradiance (fluence rate) (cPDT) is the abrupt consumption leads resistance treatment. metronomic regimens (mPDT) involving administering at low irradiation intensity over relatively long period time could be an alternative circumvent limitations protocols. The main objective present work was compare effectiveness with advanced PS based on conjugated polymer nanoparticles (CPN) developed by our group in two modalities: cPDT mPDT. vitro evaluation carried out cell viability, impact macrophage population tumor microenvironment co-culture conditions modulation HIF-1α indirect indicator consumption. mPDT CPNs resulted more effective death, lower activation molecular pathways therapeutic polarization towards antitumoral phenotype. Additionally, tested GBM heterotopic mouse model, confirming its good performance promising growth inhibition apoptotic death induction.

Язык: Английский

Процитировано

22
Alcohol inducing macrophage M2b polarization in colitis by modulating the TRPV1-MAPK/NF-κB pathways DOI
Zehua Zhang,

Zhuyun Leng,

Le Kang

и другие.

Phytomedicine, Год журнала: 2024, Номер 130, С. 155580 - 155580

Опубликована: Апрель 2, 2024

Язык: Английский

Процитировано

7
Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations DOI
Matías Daniel Caverzán, Luis Exequiel Ibarra

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134777 - 134777

Опубликована: Авг. 15, 2024

Язык: Английский

Процитировано

6
The Role of Mesenchymal Reprogramming in Malignant Clonal Evolution and Intra-Tumoral Heterogeneity in Glioblastoma DOI Creative Commons
Qiong Wu, Anders Berglund, Robert J.B. Macaulay

и другие.

Cells, Год журнала: 2024, Номер 13(11), С. 942 - 942

Опубликована: Май 30, 2024

Glioblastoma (GBM) is the most common yet uniformly fatal adult brain cancer. Intra-tumoral molecular and cellular heterogeneities are major contributory factors to therapeutic refractoriness futility in GBM. Molecular heterogeneity represented through subtype clusters whereby proneural (PN) associated with significantly increased long-term survival compared highly resistant mesenchymal (MES) subtype. Furthermore, it universally recognized that a small subset of GBM cells known as stem (GSCs) serve reservoirs for tumor recurrence progression. The clonal evolution GSC subtypes response therapy drives intra-tumoral remains critical determinant outcomes. In particular, MES reprogramming GSCs using current therapies has emerged leading hypothesis refractoriness. Preventing divergent toward via new treatments would dramatically improve patients have significant impact on this review, we examine challenges role malignant glioblastoma provide future perspectives addressing unmet need overcome resistance

Язык: Английский

Процитировано

5
The two-sided battlefield of tumour-associated macrophages in glioblastoma: unravelling their therapeutic potential DOI Creative Commons

Jingwen Xiong,

Xuancheng Zhou,

Lanqian Su

и другие.

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 25, 2024

Gliomas are the most common primary malignant tumours of central nervous system (CNS), which highly aggressive, with increasing morbidity and mortality rates year after year, posing a serious threat to quality expected survival time patients. The treatment gliomas is major challenge in field neuro-oncology, especially high-grade such as glioblastomas (GBMs). Despite considerable progress recent years study molecular cellular mechanisms GBMs, their prognosis remains bleak. Tumour-associated macrophages (TAMs) account for up 50% they heterogeneous cell population whose role cannot be ignored. Here, we focus on reviewing contribution classically activated M1-phenotype TAMs alternatively M2-phenotype exploring research reprogramming M1 into M2 TAMs.

Язык: Английский

Процитировано

5
Malignant Cells Beyond the Tumor Core: The Non‐Negligible Factor to Overcome the Refractory of Glioblastoma DOI Creative Commons

Yaou Zhou,

Qi-Lin He,

Guanglong Huang

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(3)

Опубликована: Март 1, 2025

ABSTRACT Background Glioblastoma (GBM) is one of the most aggressive primary brain tumors in adults. Over 95% GBM patients experience recurrence peritumoral tissue or distant regions, indicating presence critical factors these areas that drive tumor recurrence. Current clinical treatments primarily focus on cells from core (TC), while role neoplastic beyond TC has been largely neglected. Methods We conducted a comprehensive review existing literature and studies GBM, focusing identification characterization questionable (Q cells). Advanced imaging techniques, such as diffusion tensor (DTI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), were utilized to identify Q core. also analyzed functional properties, cellular microenvironment, physical characteristics cells, well their implications for surgical resection. Results Our revealed exhibit unique attributes, including enhanced invasiveness, metabolic adaptations, resistance mechanisms. These reside distinct microenvironment are influenced by properties solid stress stiffness. techniques have improved enabling more precise Targeting therapeutic strategies could significantly reduce risk Conclusion The zone (PBZ) factor treatments, which target TC, insufficient prevent due neglect cells. Future research should understanding mechanisms influencing developing targeted therapies improve patient outcomes.

Язык: Английский

Процитировано

0
Nanoimmunotherapy: the smart trooper for cancer therapy DOI Creative Commons
Suphiya Parveen,

Dhanshree Vikrant Konde,

Safal Kumar Paikray

и другие.

Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер 6

Опубликована: Апрель 10, 2025

Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body's immune system to fight cancer. Despite initial successes, its broader clinical application hindered by limitations such as heterogeneity in patient response challenges associated with tumor microenvironment. Recent advancements nanotechnology have offered innovative solutions these barriers, providing enhancements immunotherapy. Nanotechnology-based approaches exhibit multifaceted mechanisms, including effective anti-tumor responses during tumorigenesis overcoming suppression mechanisms improve defense capacity. Nanomedicines, nanoparticle-based vaccines, liposomes, modulators, gene delivery systems, demonstrated ability activate responses, modulate microenvironments, target specific cells. Success metrics preclinical early studies, improved survival rates, enhanced regression, elevated activation indices, highlight promise of technologies. achievements, several remain, scaling up manufacturing, addressing off-target effects, navigating regulatory complexities. The review emphasizes need for interdisciplinary address ensuring adoption. It also provides insights into approaches, advancements, transformative potential nano-immunotherapy promising results checkpoint inhibitor delivery, nanoparticle-mediated photothermal therapy, immunomodulation well inhibition nanoparticles vaccines.

Язык: Английский

Процитировано

0
Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma DOI Creative Commons
Jin Zhang, Shuting Li, Yuan Wang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 15, 2025

Objective Tumor-associated macrophages (TAMs) constitute a significant proportion of the immune cell population within brain tumors. The polarization exerts an important influence on tumor microenvironment (TME). Nevertheless, specific role TAMs in sonic hedgehog (SHH) medulloblastoma remains unclear. To investigate characteristics and effects SHH medulloblastoma, we evaluated infiltration M1 M2 tissues analyzed correlation between recruitment clinical outcome patients. Methods We enrolled total 42 patients diagnosed with medulloblastoma. Using multiple immunofluorescence staining paraffin-embedded sections, detected activated phenotype (M1/M2) by monoclonal antibodies for CD68, HLA-DR CD163. Subsequently, as well prognostic factors. Results median age (31 boys, 11 girls) was 5.3 years (range: 0.8-15.1 years). All had confirmed pathological types, including 4 cases classic (CMB), 33 desmoplastic/nodular (DNMB), 3 extensive nodularity (MBEN), 2 large-cell/anaplastic (LCA). Thirteen presented metastasis at diagnosis, while twenty-nine were without metastasis. Four high-risk genetic abnormalities. Different proportions found collected tissues, large amounts CD68 + CD163 cells found. study revealed that M (total macrophages) mix (CD68 cells) significantly higher group <5 old ( P < 0.05), non-metastatic than metastatic = 0.043). CMB DNMB/MBEN 0.036), children abnormalities 0.007). Five-year PFS poorer ≥5 0.05). High better 5-year 0.000), whereas high both OS 0.001, 0.001). Multivariate analysis showed independent factors PFS, factor OS. Conclusion increase predicts especially might be therapeutic target

Язык: Английский

Процитировано

0
The role of angiogenic growth factors in the immune microenvironment of glioma DOI Creative Commons

Zhengmao Ge,

Qi Zhang,

Wei Lin

и другие.

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Сен. 13, 2023

Angiogenic growth factors (AGFs) are a class of secreted cytokines related to angiogenesis that mainly include vascular endothelial (VEGFs), stromal-derived factor-1 (SDF-1), platelet-derived (PDGFs), fibroblast (FGFs), transforming factor-beta (TGF-β) and angiopoietins (ANGs). Accumulating evidence indicates the role AGFs is not only limited tumor but also participating in progression by other mechanisms go beyond their angiogenic role. were shown be upregulated glioma microenvironment characterized extensive high immunosuppression. produced stromal cells can exert an immunomodulatory interacting with immune cells. This review aims sum up interactions among AGFs, cancer particular emphasis on tries provide new perspectives for understanding in-depth explorations anti-glioma therapy.

Язык: Английский

Процитировано

10
Overcoming challenges in glioblastoma treatment: targeting infiltrating cancer cells and harnessing the tumor microenvironment DOI Creative Commons
M Chiariello, Giovanni Inzalaco, Virginia Barone

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Дек. 21, 2023

Glioblastoma (GB) is a highly malignant primary brain tumor with limited treatment options and poor prognosis. Despite current approaches, including surgical resection, radiation therapy, chemotherapy temozolomide (TMZ), GB remains mostly incurable due to its invasive growth pattern, drug penetration beyond the blood-brain barrier (BBB), resistance conventional therapies. One of main challenges in effectively eliminating infiltrating cancer cells that remain parenchyma after resection. We’ve reviewed most recent surveyed potential strategies aimed at enhancing local outcomes.

Язык: Английский

Процитировано

10