Biochemical, Hematological, Inflammatory, and Gut Permeability Biomarkers in Patients with Alcohol Withdrawal Syndrome with and without Delirium Tremens

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(10), С. 2776 - 2776

Опубликована: Май 8, 2024

Background: Delirium Tremens (DT) is known to be a serious complication of alcohol withdrawal syndrome (AWS). Neurotransmitter abnormalities, inflammation, and increased permeability are associated with the pathogenesis AWS DT. However, biomarkers these conditions still poorly understood. Methods: In this work, biochemical, hematologic, inflammatory, gut were investigated in following three groups: healthy controls (n = 75), severe patients DT 28), mild/moderate without 97). Blood sampling was performed after resolution acute condition (on 5 ± 1 day admission) collect clinical information from investigate associations scales. Biomarker analysis using automated analyzers ELISA. Inflammatory included erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), platelet-to-lymphocyte ratio (PLR). Results: Among biochemical biomarkers, only glucose, total cholesterol, alanine aminotransferase (ALT) changed significantly analyzed groups. A multiple regression showed that age ALT independent predictors CIWA-Ar score. Hematologic biomarker an white blood cell count, elevated size greater variability red cells platelets (MCV, RDWc, PDWc) two groups patients. Gut (FABP2, LBP, zonulin) did not change, but comorbid pathologies (alcohol liver disease pancreatitis). The increase inflammatory (ESR PLR) more evident Cluster confirmed existence subgroup evidence high such frequent Conclusions: These findings contribute understanding support heterogeneity by level inflammation.

Язык: Английский

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Building Predictive Models for Schizophrenia Diagnosis with Peripheral Inflammatory Biomarkers

Biomedicines, Год журнала: 2023, Номер 11(7), С. 1990 - 1990

Опубликована: Июль 14, 2023

Machine learning and artificial intelligence technologies are known to be a convenient tool for analyzing multi-domain data in precision psychiatry. In the case of schizophrenia, most commonly used sources such purposes neuroimaging, voice language patterns, mobile phone data. Data on peripheral markers can also useful building predictive models. Here, we have developed five models binary classification schizophrenia patients healthy individuals. serum concentrations cytokines, chemokines, growth factors, age were among 38 parameters build these The sample consisted 217 90 architecture was involved logistic regression, deep neural networks, decision trees, support vector machine, k-nearest neighbors algorithms. It shown that algorithm based network (consisting layers) showed slightly higher sensitivity (0.87 ± 0.04) specificity (0.52 0.06) than other Combining all variables into single classifier cumulative effect exceeded effectiveness individual variables, indicating need use multiple biomarkers diagnose schizophrenia. Thus, obtained promise using machine methods diagnosing

Язык: Английский

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Serum BAFF, APRIL, TWEAK, TNFSF18, TNFR2, and TNFRS12A levels in preschool children with autism spectrum disorder

International Journal of Developmental Disabilities, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Май 29, 2024

Objectives A gradually increasing number of studies have reported that dysregulation in the immune system may be a contributing factor etiopathogenesis autism spectrum disorder (ASD). However, only limited data has existed about role tumor necrosis (TNF) superfamily members ASD. This study aimed to investigate whether serum levels BAFF, APRIL, TWEAK, TNFSF18 TNFR2, and TNFRS12A are associated with ASD preschool children.

Язык: Английский

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Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIV

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 10, 2024

The catecholamine neurotransmitter dopamine is classically known for regulation of central nervous system (CNS) functions such as reward, movement, and cognition. Increasing evidence also indicates that regulates critical in peripheral organs an important immunoregulatory factor. We have previously shown increases NF-κB activity, inflammasome activation, the production inflammatory cytokines IL-1β human macrophages. As myeloid lineage cells are to initiation resolution acute responses, dopamine-mediated dysregulation these could both impair innate immune response exacerbate chronic inflammation. However, exact pathways by which drives inflammation not well defined, studies rodent systems indicate can impact mediators through D1-like receptors (DRD1, DRD5) D2-like (DRD2, DRD3, DRD4). Therefore, we hypothesized regulated ratio different activated. Our data primary monocyte-derived macrophages (hMDM) DRD1 expression necessary IL-1β, changes DRD2 other alter magnitude increase IL-1β. Mature hMDM a high receptor ratio, relative monocytes blood mononuclear (PBMCs). further confirm microglia cell lines promotes dopamine-induced gene protein using pharmacological inhibition or overexpression receptors. RNA-sequencing dopamine-treated shows genes encoding signaling pathways, neurotransmission increased with treatment. Finally, HIV example disease substantively worsened comorbid substance use disorders (SUDs) dopaminergic signaling, show effects on activation presence microglia. These suggest addictive substances dopamine-modulating therapeutics dysregulate neuroimmunological conditions like HIV. Thus, detailed understanding inflammation, particular regulating will be effectively tailor medication regimens.

Язык: Английский

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The Inflammation in Schizophrenia: Biomarkers and Association with Pathogenesis

Springer eBooks, Год журнала: 2024, Номер unknown, С. 1 - 28

Опубликована: Янв. 1, 2024

Язык: Английский

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The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis

S S Korsakov Journal of Neurology and Psychiatry, Год журнала: 2024, Номер 124(10), С. 85 - 85

Опубликована: Янв. 1, 2024

To evaluate the associations between peripheral levels of inflammatory markers and willingness to exert effort in individuals at clinical high risk for psychosis (CHR-P) a role fatigue as mediator these associations.

Язык: Английский

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Distinct white matter abnormalities and cognitive impairments in deficit schizophrenia: a cross-sectional diffusion tensor imaging study

Journal of Psychiatric Research, Год журнала: 2024, Номер 181, С. 381 - 390

Опубликована: Ноя. 30, 2024

Язык: Английский

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