Brain Sciences,
Год журнала:
2024,
Номер
14(4), С. 323 - 323
Опубликована: Март 27, 2024
Epilepsy
is
one
of
the
most
common
neurological
disorders
globally,
affecting
about
50
million
people,
with
nearly
80%
those
affected
residing
in
low-
and
middle-income
countries.
It
characterized
by
recurrent
seizures
that
result
from
abnormal
electrical
brain
activity,
varying
widely
manifestation.
The
exploration
biomechanical
effects
have
on
dynamics
stress
levels
relevant
for
development
more
effective
treatments
protective
strategies.
This
study
uses
a
blend
experimental
data
computational
simulations
to
assess
brain’s
physical
response
during
seizures,
particularly
focusing
behavior
cerebrospinal
fluid
resulting
mechanical
stresses
different
regions.
Notable
findings
show
increases
stress,
predominantly
posterior
gyri
brainstem,
an
evidence
displacement
relative
skull.
These
observations
suggest
dynamic
complex
interaction
between
skull,
maximum
shear
regions
demonstrating
limited
yet
essential
role
CSF.
By
providing
deeper
understanding
changes
occurring
this
research
supports
goal
advancing
diagnostic
tools,
informing
targeted
treatment
interventions,
guiding
creation
customized
therapeutic
strategies
enhance
care
protect
against
adverse
seizures.
Cells,
Год журнала:
2024,
Номер
13(6), С. 466 - 466
Опубликована: Март 7, 2024
Cannabinoids
have
shown
potential
in
drug-resistant
epilepsy
treatment;
however,
we
lack
knowledge
on
which
cannabinoid(s)
to
use,
dosing,
and
their
pharmacological
targets.
This
study
investigated
(i)
the
anticonvulsant
effect
of
Cannabidiol
(CBD)
alone
(ii)
combination
with
Delta-9
Tetrahydrocannabinol
(Δ9-THC),
as
well
(iii)
serotonin
(5-HT)1A
receptor’s
role
CBD’s
mechanism
action.
Seizure
activity,
induced
by
4-aminopyridine,
was
measured
extracellular
field
recordings
cortex
layer
2/3
mouse
brain
slices.
The
10,
30,
100
µM
CBD
combined
Δ9-THC
evaluated.
To
examine
action,
slices
were
pre-treated
a
5-HT1A
receptor
antagonist
before
An
amount
≥30
exerted
significant
effects
while
10
did
not.
However,
low-dose
(20:3
ratio)
displayed
significantly
greater
than
either
phytocannabinoid
alone.
Furthermore,
blocking
receptors
application
abolished
effects.
Thus,
our
results
demonstrate
efficacy
that
exerts
its
effects,
at
least
part,
through
receptors.
These
could
address
drug-resistance
providing
insight
into
laying
groundwork
for
further
testing
cannabinoids
anticonvulsants.
Fundamental Research,
Год журнала:
2024,
Номер
5(1), С. 103 - 114
Опубликована: Июнь 24, 2024
To
derive
critical
signal
features
from
intracranial
electroencephalograms
of
epileptic
patients
in
order
to
design
instructions
for
feedback-type
electrical
stimulation
systems.
The
Detrended
Fluctuation
Analysis
(DFA)
exponent
is
chosen
as
the
classification
exponent,
and
disparities
between
indicators
representing
distinct
seizure
states
efficacy
rudimentary
machine
learning
models
are
computed.
DFA
exhibited
a
statistically
significant
variation
among
pre-ictal,
ictal
period,
post-ictal
stages.
Linear
Discriminant
model
demonstrates
highest
accuracy
three
basic
models,
whereas
Naive
Bayesian
necessitates
least
amount
computational
storage
space.
set
exponents
employed
an
intermediary
variable
process.
resultant
possesses
capability
function
feedback
trigger
program
systems
variety,
specifically
within
domain
neural
modulation
epilepsy.
International Journal of Advanced Research in Science Communication and Technology,
Год журнала:
2025,
Номер
unknown, С. 375 - 378
Опубликована: Янв. 7, 2025
Combination
therapy
has
emerged
as
a
vital
strategy
for
enhancing
treatment
outcomes
and
improving
the
quality
of
life
individuals
with
epilepsy.
This
approach
involves
administering
multiple
antiepileptic
drugs
(AEDs)
simultaneously
to
achieve
better
seizure
control,
improved
efficacy,
reduced
side
effects.
Research
shown
that
certain
AED
combinations,
such
valproate,
exhibit
remarkable
synergy,
producing
supra-additive
anticonvulsant
However,
careful
risk-benefit
assessments
are
necessary
mitigate
potential
increased
review
highlights
benefits
challenges
combination
in
epilepsy,
discusses
mechanisms
action
various
explores
personalized
medicine
approaches
optimize
control
improve
patient
International Journal of Developmental Neuroscience,
Год журнала:
2025,
Номер
85(1)
Опубликована: Янв. 7, 2025
ABSTRACT
Autism
spectrum
disorder
(ASD)
is
a
complex
challenge,
influenced
by
genetic
and
environmental
factors.
This
review
focuses
on
the
proteins
calbindin
(CB),
calretinin
(CR)
parvalbumin
(PV)
in
context
of
ASD,
exploring
their
clinical
correlations
providing
deeper
understanding
spectrum.
In
addition,
we
seek
to
understand
role
these
GABAergic
regulation
implication
pathophysiology
ASD.
The
studies
reviewed
revealed
significant
decrease
PV+
interneurons
prefrontal
cortex
individuals
with
ASD
compared
typical
controls.
reduction
associated
local
synaptic
hyperconnectivity,
characterized
an
increase
number
excitatory
synapses
inhibitory
synapses.
A
correlation
was
also
observed
between
severity
behavioural
symptoms
research
highlights
imbalance
as
crucial
component
neuropathology
highlighting
calcium‐binding
proteins,
especially
PV,
regulating
neuronal
excitability
modulating
connectivity.
These
findings
provide
valuable
insights
for
development
new
therapeutic
strategies
intended
modulate
activity
improve
WSEAS TRANSACTIONS ON SIGNAL PROCESSING,
Год журнала:
2025,
Номер
21, С. 13 - 18
Опубликована: Фев. 13, 2025
The
technology
used
for
processing
EEG
signals
from
the
brain
a
specific
application
is
called
brain-computer
interface
(BCI).
This
method
has
numerous
applications
as
non-intrusive
signal
capture
technique.
Hardware
accelerators
are
to
implement
an
accurate
and
stable
system
capturing
these
lowfrequency
signals,
acquisition
highly
sensitive,
particularly
in
seizure
detection.
A
critical
challenge
this
integration
precisely
synchronizing
with
hardware
accelerator
ensure
real-time
detection
of
epileptic
seizures.
Detecting
requires
collecting
much
data
brain's
electrical
activity.
general
performance
CPU
not
enough
handle
massive
data.
So,
proposed
FPGAs
(Field-Programmable
Gate
Arrays)
family
Zynq
7000
series
accelerator.
offer
designer
benefits
custom
design,
eliminating
costly
development
expenses
time-consuming
production
processes.
article
aims
propose
VLSI
design
using
built-in
IP
cores
provided
by
Xilinx
evaluate
delay
that
can
synchronize
built
memory
FPGA
acquired
signals.
Experimental
results
demonstrate
approach
enables
creation
controllable
platform
minimum
step
less
than
1ns
maximum
time
exceeding
200us,
compared
skew,
resulting
efficacy
unit
providing
seamless
synchronization,
enhancing
overall
EEG-based
system.
post-synthesis
estimated
power
134mW,
setup
0.420nS,
hold
5.713nS.
Journal of Integrative Neuroscience,
Год журнала:
2025,
Номер
24(2)
Опубликована: Фев. 20, 2025
Neuroregulatory
therapy,
encompassing
deep
brain
stimulation
and
responsive
neurostimulation,
is
increasingly
gaining
attention
for
the
treatment
of
drug-resistant
temporal
occipital
lobe
epilepsy.
Beyond
approved
anterior
nucleus
thalamus,
pulvinar
thalamus
a
potential
target.
Through
confluence
animal
studies,
electrophysiological
research,
imaging
has
been
identified
as
having
extensive
connections
with
visual
cortex,
prefrontal
limbic
regions,
multimodal
sensory
associative
areas,
playing
pivotal
role
in
multisensory
integration
serving
propagation
node
both
generalized
focal
This
review
synthesizes
recent
research
on
relation
to
cortical
epileptic
networks,
well
efficacy
neuroregulatory
therapy
targeting
Further
warranted
elucidate
differential
therapeutic
effects
stimulating
various
subregions
specific
mechanisms
underlying
epilepsy
through
stimulation.
